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    Stimuli-Responsive Liposomes for Controlled Drug Delivery

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    Name:
    Final Dissertation thesis-Wengang ...
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    Description:
    Dissertation
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    Type
    Dissertation
    Authors
    Li, Wengang cc
    Advisors
    Khashab, Niveen M. cc
    Committee Members
    Takanabe, Kazuhiro cc
    Han, Yu cc
    Wang, Peng cc
    Program
    Chemical Sciences
    KAUST Department
    Physical Sciences and Engineering (PSE) Division
    Date
    2014-09
    Permanent link to this record
    http://hdl.handle.net/10754/335801
    
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    Abstract
    Liposomes are promising drug delivery vesicles due to their biodegradibility, large volume and biocompatibility towards both hydrophilic and hydrophobic drugs. They suffer, however, from poor stability which limits their use in controlled delivery applications. Herein, a novel method was devised for modification of liposomes with small molecules, polymers or nanoparticles to afford stimuli responsive systems that release on demand and stay relatively stable in the absence of the trigger.. This dissertation discusses thermosensitive, pH sensitive, light sensitive and magnetically triggered liposomes that have been prepared for controlled drug delivery application. RAFT polymerization was utilized for the preparation of thermosensitive liposomes (Cholesterol-PNIPAm) and acid-labile liposomes (DOPE-PAA). With low Mw Cholesterol-PNIPAm, the thermosensitive liposomes proved to be effective for controlled release and decreased the cytotoxicity of PNIPAm by eliciting the polymer doses. By crosslinking the DOPE-PAA on liposome surface with acid-labile diamine linkers, DOPE-PAA liposomes were verified to be sensitive at low pH. The effects of polymer structures (linear or hyperbranched) have also been studied for the stability and release properties of liposomes. Finally, a dual-responsive Au@SPIO embedded liposome hybrid (ALHs) was prepared with light-induced “on-and-off” function by photo-thermal process (visible light) and instant release properties triggered by alternating magnetic field, respectively. The ALH system would be further applied into the cellular imaging field as MRI contrast agent.
    DOI
    10.25781/KAUST-AR5XB
    ae974a485f413a2113503eed53cd6c53
    10.25781/KAUST-AR5XB
    Scopus Count
    Collections
    Dissertations; Physical Sciences and Engineering (PSE) Division; Chemical Science Program

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