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dc.contributor.authorSibillano, T.
dc.contributor.authorDe Caro, L.
dc.contributor.authorAltamura, D.
dc.contributor.authorSiliqi, D.
dc.contributor.authorRamella, M.
dc.contributor.authorBoccafoschi, F.
dc.contributor.authorCiasca, G.
dc.contributor.authorCampi, G.
dc.contributor.authorTirinato, Luca
dc.contributor.authorDi Fabrizio, Enzo M.
dc.contributor.authorGiannini, C.
dc.date.accessioned2014-11-16T07:24:22Z
dc.date.available2014-11-16T07:24:22Z
dc.date.issued2014-11-10
dc.identifier.citationSibillano, T., De Caro, L., Altamura, D., Siliqi, D., Ramella, M., Boccafoschi, F., . . . Giannini, C. (2014). An Optimized Table-Top Small-Angle X-ray Scattering Set-up for the Nanoscale Structural Analysis of Soft Matter. Sci. Rep., 4. doi: 10.1038/srep06985
dc.identifier.issn2045-2322
dc.identifier.pmid25382272
dc.identifier.doi10.1038/srep06985
dc.identifier.urihttp://hdl.handle.net/10754/334951
dc.description.abstractThe paper shows how a table top superbright microfocus laboratory X-ray source and an innovative restoring-data algorithm, used in combination, allow to analyze the super molecular structure of soft matter by means of Small Angle X-ray Scattering ex-situ experiments. The proposed theoretical approach is aimed to restore diffraction features from SAXS profiles collected from low scattering biomaterials or soft tissues, and therefore to deal with extremely noisy diffraction SAXS profiles/maps. As biological test cases we inspected: i) residues of exosomes' drops from healthy epithelial colon cell line and colorectal cancer cells; ii) collagen/human elastin artificial scaffolds developed for vascular tissue engineering applications; iii) apoferritin protein in solution. Our results show how this combination can provide morphological/structural nanoscale information to characterize new artificial biomaterials and/or to get insight into the transition between healthy and pathological tissues during the progression of a disease, or to morphologically characterize nanoscale proteins, based on SAXS data collected in a room-sized laboratory.
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.urlhttp://www.nature.com/doifinder/10.1038/srep06985
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCharacterization and analytical techniques
dc.subjectX-rays
dc.titleAn Optimized Table-Top Small-Angle X-ray Scattering Set-up for the Nanoscale Structural Analysis of Soft Matter
dc.typeArticle
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Division
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalScientific Reports
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionIstituto di Cristallografia (IC-CNR), via Amendola 122/O, I-70126 Bari, Italy
dc.contributor.institutionDepartment of Health Sciences, University of Piemonte Orientale “A. Avogadro”, 28100 Novara, Italy
dc.contributor.institutionIstituto di Fisica, Universitá Cattolica S. Cuore, L.go Francesco Vito 1 I-00168, Roma, Italy
dc.contributor.institutionIstituto di Cristallografia (IC-CNR), Via Salaria Km 29.300, 00015 Monterotondo, Roma, Italy
dc.contributor.institutionBIONEMlab University Magna Graecia, Department of Clinical and Experimental Medicine, Viale Europa, 88100 Catanzaro, Italy
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personDi Fabrizio, Enzo M.
kaust.personDi Fabrizio, Enzo M.
kaust.personTirinato, Luca
kaust.personTirinato, Luca
refterms.dateFOA2018-06-13T13:27:04Z


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