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dc.contributor.authorSchaefer, Ulf
dc.contributor.authorSchmeier, Sebastian
dc.contributor.authorBajic, Vladimir B.
dc.date.accessioned2014-11-11T14:30:42Z
dc.date.available2014-11-11T14:30:42Z
dc.date.issued2010-10-21
dc.identifier.citationSchaefer U, Schmeier S, Bajic VB (2010) TcoF-DB: dragon database for human transcription co-factors and transcription factor interacting proteins. Nucleic Acids Research 39: D106-D110. doi:10.1093/nar/gkq945.
dc.identifier.issn0305-1048
dc.identifier.pmid20965969
dc.identifier.doi10.1093/nar/gkq945
dc.identifier.urihttp://hdl.handle.net/10754/334582
dc.description.abstractThe initiation and regulation of transcription in eukaryotes is complex and involves a large number of transcription factors (TFs), which are known to bind to the regulatory regions of eukaryotic DNA. Apart from TF-DNA binding, protein-protein interaction involving TFs is an essential component of the machinery facilitating transcriptional regulation. Proteins that interact with TFs in the context of transcription regulation but do not bind to the DNA themselves, we consider transcription co-factors (TcoFs). The influence of TcoFs on transcriptional regulation and initiation, although indirect, has been shown to be significant with the functionality of TFs strongly influenced by the presence of TcoFs. While the role of TFs and their interaction with regulatory DNA regions has been well-studied, the association between TFs and TcoFs has so far been given less attention. Here, we present a resource that is comprised of a collection of human TFs and the TcoFs with which they interact. Other proteins that have a proven interaction with a TF, but are not considered TcoFs are also included. Our database contains 157 high-confidence TcoFs and additionally 379 hypothetical TcoFs. These have been identified and classified according to the type of available evidence for their involvement in transcriptional regulation and their presence in the cell nucleus. We have divided TcoFs into four groups, one of which contains high-confidence TcoFs and three others contain TcoFs which are hypothetical to different extents. We have developed the Dragon Database for Human Transcription Co-Factors and Transcription Factor Interacting Proteins (TcoF-DB). A web-based interface for this resource can be freely accessed at http://cbrc.kaust.edu.sa/tcof/ and http://apps.sanbi.ac.za/tcof/. © The Author(s) 2010.
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rightsArchived with thanks to Nucleic Acids Research
dc.rights.urihttp://creativecommons.org/licenses/by-nc/2.5/
dc.subjecttranscription co factor
dc.subjecttranscription factor
dc.subjectunclassified drug
dc.subjectcell nucleus
dc.subjectcomputer interface
dc.subjectprotein analysis
dc.subjectprotein database
dc.subjectprotein localization
dc.subjectprotein protein interaction
dc.subjectTcoF DB
dc.subjecttranscription regulation
dc.subjectweb browser
dc.subjectCarrier Proteins
dc.subjectDatabases, Protein
dc.subjectProtein Interaction Mapping
dc.subjectTranscription Factors
dc.subjectTranscription, Genetic
dc.subjectEukaryota
dc.titleTcoF-DB: dragon database for human transcription co-factors and transcription factor interacting proteins
dc.typeArticle
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.identifier.journalNucleic Acids Research
dc.identifier.pmcidPMC3013796
dc.eprint.versionPublisher's Version/PDF
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personSchmeier, Sebastian
kaust.personSchaefer, Ulf
kaust.personBajic, Vladimir B.
refterms.dateFOA2018-06-14T04:39:17Z


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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.