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dc.contributor.authorGentile, F.
dc.contributor.authorColuccio, M.L.
dc.contributor.authorLimongi, Tania
dc.contributor.authorPerozziello, G.
dc.contributor.authorCandeloro, P.
dc.contributor.authorDi Fabrizio, Enzo M.
dc.date.accessioned2014-11-11T14:29:15Z
dc.date.available2014-11-11T14:29:15Z
dc.date.issued2014-05-05
dc.identifier.citationGentile F, Coluccio M, Limongi T, Perozziello G, Candeloro P, et al. (2014) The Five Ws (and one H) of Super-Hydrophobic Surfaces in Medicine. Micromachines 5: 239-262. doi:10.3390/mi5020239.
dc.identifier.issn2072666X
dc.identifier.doi10.3390/mi5020239
dc.identifier.urihttp://hdl.handle.net/10754/334548
dc.description.abstractSuper-hydrophobic surfaces (SHSs) are bio-inspired, artificial microfabricated interfaces, in which a pattern of cylindrical micropillars is modified to incorporate details at the nanoscale. For those systems, the integration of different scales translates into superior properties, including the ability of manipulating biological solutions. The five Ws, five Ws and one H or the six Ws (6W), are questions, whose answers are considered basic in information-gathering. They constitute a formula for getting the complete story on a subject. According to the principle of the six Ws, a report can only be considered complete if it answers these questions starting with an interrogative word: who, why, what, where, when, how. Each question should have a factual answer. In what follows, SHSs and some of the most promising applications thereof are reviewed following the scheme of the 6W. We will show how these surfaces can be integrated into bio-photonic devices for the identification and detection of a single molecule. We will describe how SHSs and nanoporous silicon matrices can be combined to yield devices with the capability of harvesting small molecules, where the cut-off size can be adequately controlled. We will describe how this concept is utilized for obtaining a direct TEM image of a DNA molecule. 2014 by the authors; licensee MDPI, Basel, Switzerland.
dc.language.isoen
dc.publisherMDPI AG
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rightsArchived with thanks to Micromachines
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subjectBiosensors
dc.subjectElectroless deposition
dc.subjectNano-optics
dc.subjectNanoporous silicon
dc.subjectNanosensors
dc.subjectSingle molecule detection
dc.subjectSuper-hydrophobic surfaces
dc.subjectElectroless plating
dc.subjectMolecules
dc.subjectSilicon
dc.subjectSurface chemistry
dc.subjectBiological solutions
dc.subjectMicrofabricated
dc.subjectNano-porous silicon
dc.subjectNanooptics
dc.subjectSingle molecule
dc.subjectSingle-molecule detection
dc.subjectSmall molecules
dc.subjectHydrophobicity
dc.titleThe five Ws (and one H) of super-hydrophobic surfaces in medicine
dc.typeArticle
dc.contributor.departmentMaterials Science and Engineering Program
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Division
dc.identifier.journalMicromachines
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionIstituto Italiano di Tecnologia, 16163 Genova, Italy
dc.contributor.institutionDepartment of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personLimongi, Tania
kaust.personDi Fabrizio, Enzo M.
refterms.dateFOA2018-06-13T15:49:34Z


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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.