KAUST DepartmentComputational Bioscience Research Center (CBRC)
Applied Mathematics and Computational Science Program
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Online Publication Date2013-10-15
Print Publication Date2013-12
Permanent link to this recordhttp://hdl.handle.net/10754/334531
MetadataShow full item record
AbstractTechnological improvements have resulted in increased discovery of new microRNAs (miRNAs) and refinement and enrichment of existing miRNA families. miRNA families are important because they suggest a common sequence or structure configuration in sets of genes that hint to a shared function. Exploratory tools to enhance investigation of characteristics of miRNA families and the functions of family-specific miRNA genes are lacking. We have developed, miRNAVISA, a user-friendly web-based tool that allows customized interrogation and comparisons of miRNA families for hypotheses generation, and comparison of per-species chromosomal distribution of miRNA genes in different families. This study illustrates hypothesis generation using miRNAVISA in seven species. Our results unveil a subclass of miRNAs that may be regulated by genomic imprinting, and also suggest that some miRNA families may be species-specific, as well as chromosome- and/or strand-specific.
CitationKamanu TKK, Radovanovic A, Archer JAC, Bajic VB (2013) Exploration of miRNA families for hypotheses generation. Sci Rep 3. doi:10.1038/srep02940.
PublisherNature Publishing Group
PubMed Central IDPMC3796740
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/3.0/
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