PH responsive self-assembly of cucurbiturils and polystyrene-block- polyvinylpyridine micelles for hydrophobic drug delivery
KAUST DepartmentAdvanced Membranes and Porous Materials Research Center
Chemical Science Program
Environmental Science and Engineering Program
Physical Science and Engineering (PSE) Division
Smart Hybrid Materials (SHMs) lab
Permanent link to this recordhttp://hdl.handle.net/10754/334525
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AbstractPolystyrene-block-polyvinylpyridine (PS-b-P4VP) polypseudorotaxanes with cucurbiturils (CB) were prepared from water soluble PS-b-P4VPH+ polymer and CB in aqueous solution at room temperature. At acidic and neutral pH, the pyridinium block of PS-b-P4VP is protonated (PS-b-P4VPH +) pushing CB to preferably host the P4VP block. At basic pH (pH 8), P4VP is not charged and thus is not able to strongly complex CB. This phenomenon was verified further by monitoring the release of pyrene, a hydrophobic cargo model, from a PS-b-P4VPH+/CB micellar membrane. Release study of UV active pyrene from the membrane at different pH values revealed that the system is only operational under basic conditions and that the host-guest interaction of CB with P4VPH+ significantly slows down cargo release.
CitationMoosa BA, Mashat A, Li W, Fhayli K, Khashab NM (2013) pH Responsive Self-Assembly of Cucurbiturils and Polystyrene-Block-Polyvinylpyridine Micelles for Hydrophobic Drug Delivery. Journal of Nanomaterials 2013: 1-6. doi:10.1155/2013/719168.
JournalJournal of Nanomaterials
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