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dc.contributor.authorMa, Lina
dc.contributor.authorCui, Peng
dc.contributor.authorZhu, Jiang
dc.contributor.authorZhang, Zhihua
dc.contributor.authorZhang, Zhang
dc.date.accessioned2014-11-11T14:27:31Z
dc.date.available2014-11-11T14:27:31Z
dc.date.issued2014-07-10
dc.identifier.citationMa L, Cui P, Zhu J, Zhang Z, Zhang Z (2014) Translational selection in human: more pronounced in housekeeping genes. Biology Direct 9: 17. doi:10.1186/1745-6150-9-17.
dc.identifier.issn17456150
dc.identifier.pmid25011537
dc.identifier.doi10.1186/1745-6150-9-17
dc.identifier.urihttp://hdl.handle.net/10754/334485
dc.description.abstractBackground: Translational selection is a ubiquitous and significant mechanism to regulate protein expression in prokaryotes and unicellular eukaryotes. Recent evidence has shown that translational selection is weakly operative in highly expressed genes in human and other vertebrates. However, it remains unclear whether translational selection acts differentially on human genes depending on their expression patterns.Results: Here we report that human housekeeping (HK) genes that are strictly defined as genes that are expressed ubiquitously and consistently in most or all tissues, are under stronger translational selection.Conclusions: These observations clearly show that translational selection is also closely associated with expression pattern. Our results suggest that human HK genes are more efficiently and/or accurately translated into proteins, which will inevitably open up a new understanding of HK genes and the regulation of gene expression.Reviewers: This article was reviewed by Yuan Yuan, Baylor College of Medicine; Han Liang, University of Texas MD Anderson Cancer Center (nominated by Dr Laura Landweber) Eugene Koonin, NCBI, NLM, NIH, United States of America Sandor Pongor, International Centre for Genetic Engineering and biotechnology (ICGEB), Italy. © 2014 Ma et al.; licensee BioMed Central Ltd.
dc.language.isoen
dc.publisherSpringer Nature
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0
dc.titleTranslational selection in human: More pronounced in housekeeping genes
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalBiology Direct
dc.identifier.pmcidPMC4100034
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionCAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, No.1 Beichen West Road, Chaoyang District, Beijing 100101, China
dc.contributor.institutionDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personCui, Peng
refterms.dateFOA2018-06-14T03:48:21Z
dc.date.published-online2014-07-10
dc.date.published-print2014


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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.