Transcriptome analysis elucidates key developmental components of bryozoan lophophore development
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Type
ArticleAuthors
Wong, Yue HimRyu, Tae Woo
Ghosheh, Yanal

Qian, Pei-Yuan

Seridi, Loqmane

Bougouffa, Salim

Ravasi, Timothy

KAUST Department
Applied Mathematics and Computational Science ProgramBiological and Environmental Sciences and Engineering (BESE) Division
Bioscience Program
Computational Bioscience Research Center (CBRC)
Computer Science Program
Integrative Systems Biology Lab
Date
2014-10-10Online Publication Date
2014-10-10Print Publication Date
2015-05Permanent link to this record
http://hdl.handle.net/10754/333562
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The most recent phylogenomic study suggested that Bryozoa (Ectoprocta), Brachiopoda, and Phoronida are monophyletic, implying that the lophophore of bryozoans, phoronids and brachiopods is a synapomorphy. Understanding the molecular mechanisms of the lophophore development of the Lophophorata clade can therefore provide us a new insight into the formation of the diverse morphological traits in metazoans. In the present study, we profiled the transcriptome of the Bryozoan (Ectoproct) Bugula neritina during the swimming larval stage (SW) and the early (4 h) and late (24 h) metamorphic stages using the Illumina HiSeq2000 platform. Various genes that function in development, the immune response and neurogenesis showed differential expression levels during metamorphosis. In situ hybridization of 23 genes that participate in the Wnt, BMP, Notch, and Hedgehog signaling pathways revealed their regulatory roles in the development of the lophophore and the ancestrula digestive tract. Our findings support the hypothesis that developmental precursors of the lophophore and the ancestrula digestive tract are pre-patterned by the differential expression of key developmental genes according to their fate. This study provides a foundation to better understand the developmental divergence and/or convergence among developmental precursors of the lophophore of bryozoans, branchiopods and phoronids.Citation
Wong, Y. H., Ryu, T., Seridi, L., Ghosheh, Y., Bougouffa, S., Qian, P.-Y., & Ravasi, T. (2014). Transcriptome analysis elucidates key developmental components of bryozoan lophophore development. Sci. Rep., 4. doi: 10.1038/srep06534Sponsors
This study was supported by a grant (DY125-15-T-02) from the China Ocean Mineral Resources Research and Development Association, an award from King Abdullah University of Science and Technology [SA-C0040/UK-C0016], and grants from the Research Grants Council of the Hong Kong Special Administrative Region [GRF661611 and GRF662413] to Pei-Yuan Qian.Publisher
Springer NatureJournal
Scientific ReportsPubMed ID
25300304Additional Links
http://www.nature.com/doifinder/10.1038/srep06534ae974a485f413a2113503eed53cd6c53
10.1038/srep06534
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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
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