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dc.contributor.authorGao, Zhao-Ming
dc.contributor.authorWang, Yong
dc.contributor.authorTian, Ren-Mao
dc.contributor.authorWong, Yue Him
dc.contributor.authorBatang, Zenon B.
dc.contributor.authorAl-Suwailem, Abdulaziz M.
dc.contributor.authorBajic, Vladimir B.
dc.contributor.authorQian, Pei-Yuan
dc.date.accessioned2014-08-27T09:52:22Z
dc.date.available2014-08-27T09:52:22Z
dc.date.issued2014-04-01
dc.identifier.citationGao Z-M, Wang Y, Tian R-M, Wong YH, Batang ZB, et al. (2014) Symbiotic Adaptation Drives Genome Streamlining of the Cyanobacterial Sponge Symbiont -Candidatus Synechococcus spongiarum.- mBio 5: e00079-14-e00079-14. doi:10.1128/mBio.00079-14.
dc.identifier.issn21507511
dc.identifier.pmid24692632
dc.identifier.doi10.1128/mBio.00079-14
dc.identifier.urihttp://hdl.handle.net/10754/325461
dc.description.abstract"Candidatus Synechococcus spongiarum" is a cyanobacterial symbiont widely distributed in sponges, but its functions at the genome level remain unknown. Here, we obtained the draft genome (1.66 Mbp, 90% estimated genome recovery) of "Ca. Synechococcus spongiarum" strain SH4 inhabiting the Red Sea sponge Carteriospongia foliascens. Phylogenomic analysis revealed a high dissimilarity between SH4 and free-living cyanobacterial strains. Essential functions, such as photosynthesis, the citric acid cycle, and DNA replication, were detected in SH4. Eukaryoticlike domains that play important roles in sponge-symbiont interactions were identified exclusively in the symbiont. However, SH4 could not biosynthesize methionine and polyamines and had lost partial genes encoding low-molecular-weight peptides of the photosynthesis complex, antioxidant enzymes, DNA repair enzymes, and proteins involved in resistance to environmental toxins and in biosynthesis of capsular and extracellular polysaccharides. These genetic modifications imply that "Ca. Synechococcus spongiarum" SH4 represents a low-light-adapted cyanobacterial symbiont and has undergone genome streamlining to adapt to the sponge's mild intercellular environment. 2014 Gao et al.
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license (http://creativecommons.org/licenses/by-nc-sa/3.0/) , which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/
dc.subjectantibiotic agent
dc.subjectmethionine
dc.subjectpolyamine
dc.subjectpolysaccharide
dc.subjectRNA 16S
dc.subjectadaptation
dc.subjectbacterial genome
dc.subjectCandidatus Synechococcus spongiarum
dc.subjectcyanobacterium
dc.subjectDNA extraction
dc.subjectDNA modification
dc.subjectDNA repair
dc.subjectDNA replication
dc.subjectgene loss
dc.subjectmetagenome
dc.subjectnucleotide sequence
dc.subjectoxidative stress
dc.subjectphotosynthesis
dc.subjectphylogenetic tree
dc.subjectphylogenomics
dc.subjectsymbiont
dc.subjectsymbiosis
dc.titleSymbiotic adaptation drives genome streamlining of the cyanobacterial sponge symbiont "Candidatus Synechococcus pongiarum"
dc.typeArticle
dc.contributor.departmentCoastal and Marine Resources Core Lab
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentApplied Mathematics and Computational Science Program
dc.identifier.journalmBio
dc.identifier.pmcidPMC3977351
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDivision of Life Science, The Hong Kong University of Science and Technology, Kowloon, Hong Kong
dc.contributor.institutionKey Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration (SOA), Xiamen, China
dc.contributor.institutionSanya Institute of Deep Sea Science and Engineering, Chinese Academy of Sciences, Hainan, China
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personBajic, Vladimir B.
kaust.personBatang, Zenon B.
kaust.personAl-Suwailem, Abdulaziz M.
dc.relation.issupplementedbybioproject:PRJNA235914
refterms.dateFOA2018-06-13T15:29:42Z
display.relations<b>Is Supplemented By:</b><br/> <ul><li><i>[Bioproject]</i> <br/> Title: SH4_Meta_454 MetagenomePublication Date: 2014-01-18. bioproject: <a href="https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA235914" >PRJNA235914</a> Handle: <a href="http://hdl.handle.net/10754/666428" >10754/666428</a></a></li></ul>
dc.date.published-online2014-04-01
dc.date.published-print2014-04-01


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This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license (http://creativecommons.org/licenses/by-nc-sa/3.0/) , which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license (http://creativecommons.org/licenses/by-nc-sa/3.0/) , which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.