The doubly conditioned frequency spectrum does not distinguish between ancient population structure and hybridization
Type
ArticleAuthors
Eriksson, Anders
Manica, Andrea
Date
2014-03-13Online Publication Date
2014-03-13Print Publication Date
2014-06Permanent link to this record
http://hdl.handle.net/10754/325448
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Distinguishing between hybridization and population structure in the ancestral species is a key challenge in our understanding of how permeable species boundaries are to gene flow. The doubly conditioned frequency spectrum (dcfs) has been argued to be a powerful metric to discriminate between these two explanations, and it was used to argue for hybridization between Neandertal and anatomically modern humans. The shape of the observed dcfs for these two species cannot be reproduced by a model that represents ancient population structure in Africa with two populations, while adding hybridization produces realistic shapes. In this letter, we show that this result is a consequence of the spatial coarseness of the demographic model and that a spatially structured stepping stone model can generate realistic dcfs without hybridization. This result highlights how inferences on hybridization between recently diverged species can be strongly affected by the choice of how population structure is represented in the underlying demographic model. We also conclude that the dcfs has limited power in distinguishing between the signals left by hybridization and ancient structure. 2014 The Author.Citation
Eriksson A, Manica A (2014) The Doubly Conditioned Frequency Spectrum Does Not Distinguish between Ancient Population Structure and Hybridization. Molecular Biology and Evolution 31: 1618-1621. doi:10.1093/molbev/msu103.Publisher
Oxford University Press (OUP)Journal
Molecular Biology and EvolutionPubMed ID
24627034PubMed Central ID
PMC4032131ae974a485f413a2113503eed53cd6c53
10.1093/molbev/msu103
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