Kinetic evidence of an apparent negative activation enthalpy in an organocatalytic process
KAUST DepartmentChemical Science Program
Homogeneous Catalysis Laboratory (HCL)
KAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Online Publication Date2013-08-30
Print Publication Date2013-12
Permanent link to this recordhttp://hdl.handle.net/10754/325391
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AbstractA combined kinetic and computational study on our tryptophan-based bifunctional thiourea catalyzed asymmetric Mannich reactions reveals an apparent negative activation enthalpy. The formation of the pre-transition state complex has been unambiguously confirmed and these observations provide an experimental support for the formation of multiple hydrogen bonding network between the substrates and the catalyst. Such interactions allow the creation of a binding cavity, a key factor to install high enantioselectivity.
CitationHan X, Lee R, Chen T, Luo J, Lu Y, et al. (2013) Kinetic Evidence of an Apparent Negative Activation Enthalpy in an Organocatalytic Process. Sci Rep 3. doi:10.1038/srep02557.
PubMed Central IDPMC3757351
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