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dc.contributor.authorLengsfeld, Bettina M.
dc.contributor.authorBerry, Kayla N.
dc.contributor.authorGhosh, Sharmistha
dc.contributor.authorTakahashi, Masateru
dc.contributor.authorFrancis, Nicole J.
dc.date.accessioned2014-08-27T09:49:35Z
dc.date.available2014-08-27T09:49:35Z
dc.date.issued2012-09-17
dc.identifier.citationLengsfeld BM, Berry KN, Ghosh S, Takahashi M, Francis NJ (2012) A Polycomb complex remains bound through DNA replication in the absence of other eukaryotic proteins. Sci Rep 2. doi:10.1038/srep00661.
dc.identifier.issn20452322
dc.identifier.pmid22993687
dc.identifier.doi10.1038/srep00661
dc.identifier.urihttp://hdl.handle.net/10754/325371
dc.description.abstractPropagation of chromatin states through DNA replication is central to epigenetic regulation and can involve recruitment of chromatin proteins to replicating chromatin through interactions with replication fork components. Here we show using a fully reconstituted T7 bacteriophage system that eukaryotic proteins are not required to tether the Polycomb complex PRC1 to templates during DNA replication. Instead, DNA binding by PRC1 can withstand passage of a simple replication fork.
dc.language.isoen
dc.publisherSpringer Nature
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subjectDNA directed DNA polymerase
dc.subjecthelicase
dc.subjectpolycomb group protein
dc.subjectvirus DNA
dc.subjectvirus protein
dc.subjectbacteriophage T7
dc.subjectbinding competition
dc.subjectchemistry
dc.subjectDNA replication
dc.subjectgenetics
dc.subjectplasmid
dc.subjectprotein binding
dc.subjectBacteriophage T7
dc.subjectBinding, Competitive
dc.subjectDNA Helicases
dc.subjectDNA Replication
dc.subjectDNA, Viral
dc.subjectDNA-Directed DNA Polymerase
dc.subjectPlasmids
dc.subjectPolycomb-Group Proteins
dc.subjectProtein Binding
dc.subjectViral Proteins
dc.titleA Polycomb complex remains bound through DNA replication in the absence of other eukaryotic proteins
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalScientific Reports
dc.identifier.pmcidPMC3443814
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDepartment of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, United States
dc.contributor.institutionDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, United States
dc.contributor.institutionPfizer Vaccine Research, 401 N., Middletown Road, Pearl River, NY, 10965, United States
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personTakahashi, Masateru
refterms.dateFOA2018-06-14T07:11:15Z
dc.date.published-online2012-09-17
dc.date.published-print2012-12


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This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
Except where otherwise noted, this item's license is described as This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/