A Polycomb complex remains bound through DNA replication in the absence of other eukaryotic proteins
Online Publication Date2012-09-17
Print Publication Date2012-12
Permanent link to this recordhttp://hdl.handle.net/10754/325371
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AbstractPropagation of chromatin states through DNA replication is central to epigenetic regulation and can involve recruitment of chromatin proteins to replicating chromatin through interactions with replication fork components. Here we show using a fully reconstituted T7 bacteriophage system that eukaryotic proteins are not required to tether the Polycomb complex PRC1 to templates during DNA replication. Instead, DNA binding by PRC1 can withstand passage of a simple replication fork.
CitationLengsfeld BM, Berry KN, Ghosh S, Takahashi M, Francis NJ (2012) A Polycomb complex remains bound through DNA replication in the absence of other eukaryotic proteins. Sci Rep 2. doi:10.1038/srep00661.
PubMed Central IDPMC3443814
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