A Polycomb complex remains bound through DNA replication in the absence of other eukaryotic proteins
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2012-09-17Online Publication Date
2012-09-17Print Publication Date
2012-12Permanent link to this record
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Propagation of chromatin states through DNA replication is central to epigenetic regulation and can involve recruitment of chromatin proteins to replicating chromatin through interactions with replication fork components. Here we show using a fully reconstituted T7 bacteriophage system that eukaryotic proteins are not required to tether the Polycomb complex PRC1 to templates during DNA replication. Instead, DNA binding by PRC1 can withstand passage of a simple replication fork.Citation
Lengsfeld BM, Berry KN, Ghosh S, Takahashi M, Francis NJ (2012) A Polycomb complex remains bound through DNA replication in the absence of other eukaryotic proteins. Sci Rep 2. doi:10.1038/srep00661.Publisher
Springer NatureJournal
Scientific ReportsPubMed ID
22993687PubMed Central ID
PMC3443814Scopus Count
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