Four new antibacterial xanthones from the marine-derived actinomycetes Streptomyces caelestis
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ArticleAuthors
Liu, Ling-LiXu, Ying
Han, Zhuang
Li, Yong-Xin
Lu, Liang
Lai, Pok-Yui
Zhong, Jia-Liang
Guo, Xianrong
Zhang, Xixiang
Qian, Pei-Yuan
KAUST Department
Advanced Nanofabrication, Imaging and Characterization Core LabCore Labs
Imaging and Characterization Core Lab
Material Science and Engineering Program
Physical Science and Engineering (PSE) Division
Date
2012-11-20Permanent link to this record
http://hdl.handle.net/10754/325359Metadata
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Four new polycyclic antibiotics, citreamicin ? A (1), citreamicin ? B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus, Staphylococcus aureus, and Bacillus subtillis. Citreamicin ? A (1), citreamicin ? B (2) and citreaglycon A (3) also exhibited low MIC values of 0.25, 0.25, and 8.0 ?g/mL, respectively, against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300. 2012 by the authors; licensee MDPI.Citation
Liu L-L, Xu Y, Han Z, Li Y-X, Lu L, et al. (2012) Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis. Marine Drugs 10: 2571-2583. doi:10.3390/md10112571.Publisher
MDPI AGJournal
Marine DrugsPubMed ID
23203278PubMed Central ID
PMC3509536Relations
Is Supplemented By:- [Dataset]
Liu, L.-L., Xu, Y., Han, Z., Li, Y.-X., Lu, L., Lai, P.-Y., Zhong, J.-L., Guo, X.-R., Zhang, X.-X., & Qian, P.-Y. (2018). CCDC 1865054: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/CCDC.CSD.CC20LR1F. DOI: 10.5517/ccdc.csd.cc20lr1f Handle: 10754/663498
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