Four new antibacterial xanthones from the marine-derived actinomycetes Streptomyces caelestis
Article - Full Text
KAUST DepartmentAdvanced Nanofabrication, Imaging and Characterization Core Lab
Imaging and Characterization Core Lab
Material Science and Engineering Program
Physical Science and Engineering (PSE) Division
Permanent link to this recordhttp://hdl.handle.net/10754/325359
MetadataShow full item record
AbstractFour new polycyclic antibiotics, citreamicin ? A (1), citreamicin ? B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus, Staphylococcus aureus, and Bacillus subtillis. Citreamicin ? A (1), citreamicin ? B (2) and citreaglycon A (3) also exhibited low MIC values of 0.25, 0.25, and 8.0 ?g/mL, respectively, against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300. 2012 by the authors; licensee MDPI.
CitationLiu L-L, Xu Y, Han Z, Li Y-X, Lu L, et al. (2012) Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis. Marine Drugs 10: 2571-2583. doi:10.3390/md10112571.
PubMed Central IDPMC3509536
RelationsIs Supplemented By:
Liu, L.-L., Xu, Y., Han, Z., Li, Y.-X., Lu, L., Lai, P.-Y., Zhong, J.-L., Guo, X.-R., Zhang, X.-X., & Qian, P.-Y. (2018). CCDC 1865054: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/CCDC.CSD.CC20LR1F. DOI: 10.5517/ccdc.csd.cc20lr1f Handle: 10754/663498
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
- Antimicrobial activity of hydrophobic xanthones from Cudrania cochinchinensis against Bacillus subtilis and methicillin-resistant Staphylococcus aureus.
- Authors: Fukai T, Oku Y, Hou AJ, Yonekawa M, Terada S
- Issue date: 2004 Sep
- Antibacterial Pentacyclic Polyketides from a Soil-Derived Streptomyces.
- Authors: Yuan J, Wang L, Ren J, Huang JP, Yu M, Tang J, Yan Y, Yang J, Huang SX
- Issue date: 2020 Jun 26
- Bioactive prenylated xanthones from the young fruits and flowers of Garcinia cowa.
- Authors: Sriyatep T, Siridechakorn I, Maneerat W, Pansanit A, Ritthiwigrom T, Andersen RJ, Laphookhieo S
- Issue date: 2015 Feb 27
- Benzophenone and xanthone derivatives from the inflorescences of Garcinia cowa.
- Authors: Trisuwan K, Ritthiwigrom T
- Issue date: 2012 Oct
- Rearranged benzophenones and prenylated xanthones from Garcinia propinqua twigs.
- Authors: Tantapakul C, Phakhodee W, Ritthiwigrom T, Cheenpracha S, Prawat U, Deachathai S, Laphookhieo S
- Issue date: 2012 Sep 28
Showing items related by title, author, creator and subject.
Label-free, electrochemical detection of methicillin-resistant staphylococcus aureus DNA with reduced graphene oxide-modified electrodesWang, Zhijuan; Zhang, Juan; Chen, Peng; Zhou, Xiaozhu; Yang, Yanli; Wu, Shixin; Niu, Li; Han, Yu; Wang, Lianhui; Chen, Peng; Boey, Freddy; Zhang, Qichun; Liedberg, Bo Gunnar; Zhang, Hua (Biosensors and Bioelectronics, Elsevier BV, 2011-05) [Article]Reduced graphene oxide (rGO)-modified glassy carbon electrode is used to detect the methicillin-resistant Staphylococcus aureus (MRSA) DNA by using electrochemical impedance spectroscopy. Our experiments confirm that ssDNA, before and after hybridization with target DNA, are successfully anchored on the rGO surface. After the probe DNA, pre-adsorbed on rGO electrode, hybridizes with target DNA, the measured impedance increases dramatically. It provides a new method to detect DNA with high sensitivity (10-13M, i.e., 100 fM) and selectivity. © 2011 Elsevier B.V.
Recombinations in staphylococcal cassette chromosome mec elements compromise the molecular detection of methicillin resistance in Staphylococcus aureusHill-Cawthorne, Grant A.; Hudson, Lyndsey O.; Abd El Ghany, Moataz; Piepenburg, Olaf; Nair, Mridul; Dodgson, Andrew; Forrest, Matthew S.; Clark, Taane G.; Pain, Arnab (PLoS ONE, Public Library of Science (PLoS), 2014-06-27) [Article]Clinical laboratories are increasingly using molecular tests for methicillin-resistant Staphylococcus aureus (MRSA) screening. However, primers have to be targeted to a variable chromosomal region, the staphylococcal cassette chromosome mec (SCCmec). We initially screened 726 MRSA isolates from a single UK hospital trust by recombinase polymerase amplification (RPA), a novel, isothermal alternative to PCR. Undetected isolates were further characterised using multilocus sequence, spa typing and whole genome sequencing. 96% of our tested phenotypically MRSA isolates contained one of the six orfX-SCCmec junctions our RPA test and commercially available molecular tests target. However 30 isolates could not be detected. Sequencing of 24 of these isolates demonstrated recombinations within the SCCmec element with novel insertions that interfered with the RPA, preventing identification as MRSA. This result suggests that clinical laboratories cannot rely solely upon molecular assays to reliably detect all methicillin-resistance. The presence of significant recombinations in the SCCmec element, where the majority of assays target their primers, suggests that there will continue to be isolates that escape identification. We caution that dependence on amplification-based molecular assays will continue to result in failure to diagnose a small proportion (?4%) of MRSA isolates, unless the true level of SCCmec natural diversity is determined by whole genome sequencing of a large collection of MRSA isolates. © 2014 Hill-Cawthorne et al.
iTRAQ-Based Quantitative Proteomic Profiling of Staphylococcus aureus Under Different Osmotic Stress ConditionsMing, Tinghong; Geng, Lingxin; Feng, Ying; Lu, Chenyang; Zhou, Jun; Li, Yanyan; Zhang, Dijun; He, Shan; Li, Ye; Cheong, Lingzhi; Su, Xiurong (Frontiers in Microbiology, Frontiers Media SA, 2019-05-29) [Article]Staphylococcus aureus (S. aureus) is an extremely halotolerant pathogenic bacterium with high osmotic stress tolerance, and it is frequently encountered in aquatic production and preservation. However, the mechanism underlying the extremely high osmotic stress tolerance of S. aureus remains unclear. In this study, the isobaric tags for relative and absolute quantification (iTRAQ) method was used to identify the differentially expressed proteins (DEPs) under different sodium chloride (NaCl) concentrations. Compared with the control group (0% NaCl), the 10 and 20% NaCl groups had 484 DEPs and 750 DEPs, respectively. Compared with the 10% NaCl group, the 20% NaCl group had 361 DEPs. Among the DEPs, proteins involved in fatty acid synthesis, proline/glycine betaine biosynthesis and transportation, stress tolerance, cell wall biosynthesis and the TCA cycle were upregulated, whereas proteins associated with biofilm formation and pathogenic infections were downregulated. The results obtained in this study indicate that under extremely high osmotic stress, modification of the cell membrane structure, increased biosynthesis and transportation of osmotic protectants, and redistribution of energy metabolism contribute to the osmotic stress tolerance of S. aureus, and the infectious ability of the bacteria may be limited. The aim of this study was to provide new insight into how S. aureus tolerates the high-salt conditions involved in aquatic production and preservation.