Four new antibacterial xanthones from the marine-derived actinomycetes Streptomyces caelestis

Abstract
Four new polycyclic antibiotics, citreamicin ? A (1), citreamicin ? B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus, Staphylococcus aureus, and Bacillus subtillis. Citreamicin ? A (1), citreamicin ? B (2) and citreaglycon A (3) also exhibited low MIC values of 0.25, 0.25, and 8.0 ?g/mL, respectively, against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300. 2012 by the authors; licensee MDPI.

Citation
Liu L-L, Xu Y, Han Z, Li Y-X, Lu L, et al. (2012) Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis. Marine Drugs 10: 2571-2583. doi:10.3390/md10112571.

Publisher
MDPI AG

Journal
Marine Drugs

DOI
10.3390/md10112571

PubMed ID
23203278

PubMed Central ID
PMC3509536

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