KAUST DepartmentComputational Bioscience Research Center (CBRC)
Applied Mathematics and Computational Science Program
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Permanent link to this recordhttp://hdl.handle.net/10754/325357
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AbstractCone snails produce a distinctive repertoire of venom peptides that are used both as a defense mechanism and also to facilitate the immobilization and digestion of prey. These peptides target a wide variety of voltage- and ligand-gated ion channels, which make them an invaluable resource for studying the properties of these ion channels in normal and diseased states, as well as being a collection of compounds of potential pharmacological use in their own right. Examples include the United States Food and Drug Administration (FDA) approved pharmaceutical drug, Ziconotide (Prialt; Elan Pharmaceuticals, Inc.) that is the synthetic equivalent of the naturally occurring ?-conotoxin MVIIA, whilst several other conotoxins are currently being used as standard research tools and screened as potential therapeutic drugs in pre-clinical or clinical trials. These developments highlight the importance of driving conotoxin-related research. A PubMed query from 1 January 2007 to 31 August 2011 combined with hand-curation of the retrieved articles allowed for the collation of 98 recently identified conotoxins with therapeutic potential which are selectively discussed in this review. Protein sequence similarity analysis tentatively assigned uncharacterized conotoxins to predicted functional classes. Furthermore, conotoxin therapeutic potential for neurodegenerative disorders (NDD) was also inferred. 2012 by the authors; licensee MDPI.
CitationEssack M, Bajic VB, Archer JAC (2012) Conotoxins that Confer Therapeutic Possibilities. Marine Drugs 10: 1244-1265. doi:10.3390/md10061244.
PubMed Central IDPMC3397437
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Except where otherwise noted, this item's license is described as This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
- Conus venoms: a rich source of novel ion channel-targeted peptides.
- Authors: Terlau H, Olivera BM
- Issue date: 2004 Jan
- Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (Ca(V) 2.2) calcium channels.
- Authors: Adams DJ, Callaghan B, Berecki G
- Issue date: 2012 May
- Conus venom peptide pharmacology.
- Authors: Lewis RJ, Dutertre S, Vetter I, Christie MJ
- Issue date: 2012 Apr
- Identification, by RT-PCR, of eight novel I₂-conotoxins from the worm-hunting cone snails Conus brunneus, Conus nux, and Conus princeps from the eastern Pacific (Mexico).
- Authors: Zamora-Bustillos R, Rivera-Reyes R, Aguilar MB, Michel-Morfín E, Landa-Jaime V, Falcón A, Heimer EP
- Issue date: 2014 Mar
- Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus.
- Authors: Himaya SW, Jin AH, Dutertre S, Giacomotto J, Mohialdeen H, Vetter I, Alewood PF, Lewis RJ
- Issue date: 2015 Oct 2
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