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dc.contributor.authorArif, Muhammad Asif
dc.contributor.authorFrank, Wolfgang
dc.contributor.authorKhraiwesh, Basel
dc.date.accessioned2014-08-27T09:48:51Z
dc.date.available2014-08-27T09:48:51Z
dc.date.issued2013-01-14
dc.identifier.citationArif M, Frank W, Khraiwesh B (2013) Role of RNA Interference (RNAi) in the Moss Physcomitrella patens. International Journal of Molecular Sciences 14: 1516-1540. doi:10.3390/ijms14011516.
dc.identifier.issn16616596
dc.identifier.pmid23344055
dc.identifier.doi10.3390/ijms14011516
dc.identifier.urihttp://hdl.handle.net/10754/325355
dc.description.abstractRNA interference (RNAi) is a mechanism that regulates genes by either transcriptional (TGS) or posttranscriptional gene silencing (PTGS), required for genome maintenance and proper development of an organism. Small non-coding RNAs are the key players in RNAi and have been intensively studied in eukaryotes. In plants, several classes of small RNAs with specific sizes and dedicated functions have evolved. The major classes of small RNAs include microRNAs (miRNAs) and small interfering RNAs (siRNAs), which differ in their biogenesis. miRNAs are synthesized from a short hairpin structure while siRNAs are derived from long double-stranded RNAs (dsRNA). Both miRNA and siRNAs control the expression of cognate target RNAs by binding to reverse complementary sequences mediating cleavage or translational inhibition of the target RNA. They also act on the DNA and cause epigenetic changes such as DNA methylation and histone modifications. In the last years, the analysis of plant RNAi pathways was extended to the bryophyte Physcomitrella patens, a non-flowering, non-vascular ancient land plant that diverged from the lineage of seed plants approximately 450 million years ago. Based on a number of characteristic features and its phylogenetic key position in land plant evolution P. patens emerged as a plant model species to address basic as well as applied topics in plant biology. Here we summarize the current knowledge on the role of RNAi in P. patens that shows functional overlap with RNAi pathways from seed plants, and also unique features specific to this species. 2013 by the authors; licensee MDPI, Basel, Switzerland.
dc.language.isoen
dc.publisherMDPI AG
dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
dc.rights.urihttp://creativecommons.org/licenses/by/3.0
dc.subjectGene silencing
dc.subjectMiRNA
dc.subjectNon-coding RNAs
dc.subjectPhyscomitrella patens
dc.subjectRNAi
dc.subjectsiRNA
dc.subjectcomplementary RNA
dc.subjectdouble stranded RNA
dc.subjectmicroRNA
dc.subjectplant RNA
dc.subjectshort hairpin RNA
dc.subjectsmall interfering RNA
dc.subjectsmall untranslated RNA
dc.subjectvegetable protein
dc.subjectDNA methylation
dc.subjectepigenetics
dc.subjecteukaryote
dc.subjectgene control
dc.subjectgene expression regulation
dc.subjecthistone modification
dc.subjectmolecular evolution
dc.subjectnucleotide sequence
dc.subjectphylogeny
dc.subjectplant gene
dc.subjectplant genome
dc.subjectplant seed
dc.subjectposttranscriptional gene silencing
dc.subjectreview
dc.subjectRNA binding
dc.subjectRNA interference
dc.subjectRNA sequence
dc.subjectRNA structure
dc.subjectRNA synthesis
dc.subjectsequence homology
dc.subjecttranscription regulation
dc.subjecttranslation regulation
dc.subjectBryophyta
dc.subjectbryophytes
dc.subjectEmbryophyta
dc.subjectEukaryota
dc.subjectSpermatophyta
dc.titleRole of RNA interference (RNAi) in the moss Physcomitrella patens
dc.typeArticle
dc.contributor.departmentDesert Agriculture Initiative
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalInternational Journal of Molecular Sciences
dc.identifier.pmcidPMC3565333
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDepartment of Molecular Developmental Biology, Nijmegen Center for Molecular Life Sciences, 6500 HB Nijmegen, Netherlands
dc.contributor.institutionPlant Molecular Cell Biology, Department I, Ludwig-Maximilians-University Munich, LMU Biocenter, Grosshaderner Strasse 2-4, 82152 Planegg-Martinsried, Germany
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personKhraiwesh, Basel
refterms.dateFOA2018-06-13T15:17:04Z


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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Except where otherwise noted, this item's license is described as This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).