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dc.contributor.authorCui, Peng
dc.contributor.authorLin, Qiang
dc.contributor.authorZhang, Lingfang
dc.contributor.authorDing, Feng
dc.contributor.authorXin, Chengqi
dc.contributor.authorZhang, Daoyong
dc.contributor.authorSun, Fanglin
dc.contributor.authorHu, Songnian
dc.contributor.authorYu, Jun
dc.date.accessioned2014-08-27T09:45:23Z
dc.date.available2014-08-27T09:45:23Z
dc.date.issued2011-08-19
dc.identifier.citationCui P, Lin Q, Zhang L, Ding F, Xin C, et al. (2011) The Disequilibrium of Nucleosomes Distribution along Chromosomes Plays a Functional and Evolutionarily Role in Regulating Gene Expression. PLoS ONE 6: e23219. doi:10.1371/journal.pone.0023219.
dc.identifier.issn19326203
dc.identifier.pmid21886783
dc.identifier.doi10.1371/journal.pone.0023219
dc.identifier.urihttp://hdl.handle.net/10754/325293
dc.description.abstractTo further understand the relationship between nucleosome-space occupancy (NO) and global transcriptional activity in mammals, we acquired a set of genome-wide nucleosome distribution and transcriptome data from the mouse cerebrum and testis based on ChIP (H3)-seq and RNA-seq, respectively. We identified a nearly consistent NO patterns among three mouse tissues-cerebrum, testis, and ESCs-and found, through clustering analysis for transcriptional activation, that the NO variations among chromosomes are closely associated with distinct expression levels between house-keeping (HK) genes and tissue-specific (TS) genes. Both TS and HK genes form clusters albeit the obvious majority. This feature implies that NO patterns, i.e. nucleosome binding and clustering, are coupled with gene clustering that may be functionally and evolutionarily conserved in regulating gene expression among different cell types. © 2011 Cui et al.
dc.language.isoen
dc.publisherPublic Library of Science (PLoS)
dc.rightsCui et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rightsArchived with thanks to PLoS ONE
dc.subjecttranscriptome
dc.subjectanimal tissue
dc.subjectcell function
dc.subjectcontrolled study
dc.subjectgene cluster
dc.subjectgene expression regulation
dc.subjectgene linkage disequilibrium
dc.subjectgene mapping
dc.subjectgenetic conservation
dc.subjecthousekeeping gene
dc.subjectmouse
dc.subjectnucleosome
dc.subjectphenotypic variation
dc.subjecttissue specificity
dc.subjecttranscription initiation
dc.subjecttranscription regulation
dc.subjectantibody specificity
dc.subjectBagg albino mouse
dc.subjectcluster analysis
dc.subjectessential gene
dc.subjectgene expression regulation
dc.subjectgenetic transcription
dc.subjectgenetics
dc.subjectmetabolism
dc.subjectmolecular evolution
dc.subjectMammalia
dc.subjectCluster Analysis
dc.subjectEvolution, Molecular
dc.subjectGene Expression Regulation
dc.subjectGenes, Essential
dc.subjectMice
dc.subjectMice, Inbred BALB C
dc.subjectNucleosomes
dc.subjectOrgan Specificity
dc.subjectTranscription, Genetic
dc.titleThe disequilibrium of nucleosomes distribution along chromosomes plays a functional and evolutionarily role in regulating gene expression
dc.typeArticle
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.identifier.journalPLoS ONE
dc.identifier.pmcidPMC3158759
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionThe CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
dc.contributor.institutionInstitute of Epigenetics and Cancer Research, School of Medicine, Tsinghua University, Beijing, China
dc.contributor.institutionGraduate School of the Chinese Academy of Sciences, Beijing, China
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personCui, Peng
kaust.personDing, Feng
refterms.dateFOA2018-06-14T03:47:49Z


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