The disequilibrium of nucleosomes distribution along chromosomes plays a functional and evolutionarily role in regulating gene expression
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ArticleAuthors
Cui, Peng
Lin, Qiang
Zhang, Lingfang
Ding, Feng
Xin, Chengqi
Zhang, Daoyong
Sun, Fanglin
Hu, Songnian
Yu, Jun
KAUST Department
Computational Bioscience Research Center (CBRC)Date
2011-08-19Metadata
Show full item recordAbstract
To further understand the relationship between nucleosome-space occupancy (NO) and global transcriptional activity in mammals, we acquired a set of genome-wide nucleosome distribution and transcriptome data from the mouse cerebrum and testis based on ChIP (H3)-seq and RNA-seq, respectively. We identified a nearly consistent NO patterns among three mouse tissues-cerebrum, testis, and ESCs-and found, through clustering analysis for transcriptional activation, that the NO variations among chromosomes are closely associated with distinct expression levels between house-keeping (HK) genes and tissue-specific (TS) genes. Both TS and HK genes form clusters albeit the obvious majority. This feature implies that NO patterns, i.e. nucleosome binding and clustering, are coupled with gene clustering that may be functionally and evolutionarily conserved in regulating gene expression among different cell types. © 2011 Cui et al.Citation
Cui P, Lin Q, Zhang L, Ding F, Xin C, et al. (2011) The Disequilibrium of Nucleosomes Distribution along Chromosomes Plays a Functional and Evolutionarily Role in Regulating Gene Expression. PLoS ONE 6: e23219. doi:10.1371/journal.pone.0023219.Publisher
Public Library of Science (PLoS)Journal
PLoS ONEISSN
19326203PubMed ID
21886783PubMed Central ID
PMC3158759Handle URI
http://hdl.handle.net/10754/325293Scopus Count
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