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    The disequilibrium of nucleosomes distribution along chromosomes plays a functional and evolutionarily role in regulating gene expression

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    Type
    Article
    Authors
    Cui, Peng cc
    Lin, Qiang
    Zhang, Lingfang
    Ding, Feng cc
    Xin, Chengqi
    Zhang, Daoyong
    Sun, Fanglin
    Hu, Songnian
    Yu, Jun
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Computational Bioscience Research Center (CBRC)
    Desert Agriculture Initiative
    Date
    2011-08-19
    Permanent link to this record
    http://hdl.handle.net/10754/325293
    
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    Abstract
    To further understand the relationship between nucleosome-space occupancy (NO) and global transcriptional activity in mammals, we acquired a set of genome-wide nucleosome distribution and transcriptome data from the mouse cerebrum and testis based on ChIP (H3)-seq and RNA-seq, respectively. We identified a nearly consistent NO patterns among three mouse tissues-cerebrum, testis, and ESCs-and found, through clustering analysis for transcriptional activation, that the NO variations among chromosomes are closely associated with distinct expression levels between house-keeping (HK) genes and tissue-specific (TS) genes. Both TS and HK genes form clusters albeit the obvious majority. This feature implies that NO patterns, i.e. nucleosome binding and clustering, are coupled with gene clustering that may be functionally and evolutionarily conserved in regulating gene expression among different cell types. © 2011 Cui et al.
    Citation
    Cui P, Lin Q, Zhang L, Ding F, Xin C, et al. (2011) The Disequilibrium of Nucleosomes Distribution along Chromosomes Plays a Functional and Evolutionarily Role in Regulating Gene Expression. PLoS ONE 6: e23219. doi:10.1371/journal.pone.0023219.
    Publisher
    Public Library of Science (PLoS)
    Journal
    PLoS ONE
    DOI
    10.1371/journal.pone.0023219
    PubMed ID
    21886783
    PubMed Central ID
    PMC3158759
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0023219
    Scopus Count
    Collections
    Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Computational Bioscience Research Center (CBRC); Desert Agriculture Initiative

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