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    Computational analysis of candidate disease genes and variants for Salt-sensitive hypertension in indigenous Southern Africans

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    Type
    Article
    Authors
    Tiffin, Nicki
    Meintjes, Ayton
    Ramesar, Rajkumar
    Bajic, Vladimir B. cc
    Rayner, Brian
    KAUST Department
    Computational Bioscience Research Center (CBRC)
    Applied Mathematics and Computational Science Program
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Date
    2010-09-27
    Permanent link to this record
    http://hdl.handle.net/10754/325286
    
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    Abstract
    Multiple factors underlie susceptibility to essential hypertension, including a significant genetic and ethnic component, and environmental effects. Blood pressure response of hypertensive individuals to salt is heterogeneous, but salt sensitivity appears more prevalent in people of indigenous African origin. The underlying genetics of salt-sensitive hypertension, however, are poorly understood. In this study, computational methods including text- and data-mining have been used to select and prioritize candidate aetiological genes for salt-sensitive hypertension. Additionally, we have compared allele frequencies and copy number variation for single nucleotide polymorphisms in candidate genes between indigenous Southern African and Caucasian populations, with the aim of identifying candidate genes with significant variability between the population groups: identifying genetic variability between population groups can exploit ethnic differences in disease prevalence to aid with prioritisation of good candidate genes. Our top-ranking candidate genes include parathyroid hormone precursor (PTH) and type-1angiotensin II receptor (AGTR1). We propose that the candidate genes identified in this study warrant further investigation as potential aetiological genes for salt-sensitive hypertension. © 2010 Tiffin et al.
    Citation
    Tiffin N, Meintjes A, Ramesar R, Bajic VB, Rayner B (2010) Computational Analysis of Candidate Disease Genes and Variants for Salt-Sensitive Hypertension in Indigenous Southern Africans. PLoS ONE 5: e12989. doi:10.1371/journal.pone.0012989.
    Publisher
    Public Library of Science (PLoS)
    Journal
    PLoS ONE
    DOI
    10.1371/journal.pone.0012989
    PubMed ID
    20886000
    PubMed Central ID
    PMC2946338
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0012989
    Scopus Count
    Collections
    Articles; Applied Mathematics and Computational Science Program; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

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