Recent Submissions

  • Composite epigenetic biomarkers for accurate screening, diagnosis and prognosis of colorectal cancer

    Bajic, Vladimir B.; Incitti, Roberto; Mansour, Hicham (2018-11-22) [Patent]
    The present disclosure concerns particular biomarkers for screening, diagnosing and/or prognosticating colorectal cancer, in particular in an accurate manner. The methods and compositions concern analysis of methylation patterns of one or more of 176 methylatable genomic DNA regions identified as described herein. In particular embodiments there are methods of detecting methylatable regions in genomic sequences.
  • Two-Stage Corrosion Under Insulation Detection Methodology and Modular Vehicle with Dual Locomotion Sensory Systems

    Amer, Ayman Mohamed Mahmoud; Shehri, Ali; Parrott, Brian Jonathan (2018-11-22) [Patent]
    Methods and systems for inspecting insulated equipment for corrosion under insulation are provided. The system includes an autonomous unmanned vehicle having aerial and ground locomotive capabilities. The vehicle includes an infrared detector and a pulsed eddy current sensor. In the method, infrared waves emitted from the equipment are detected along the equipment with the infrared detector. Using the infrared detector, at least one image of an inner surface of the equipment is developed based on the detected infrared waves. At least one area that is susceptible to corrosion is determined based on the at least one image. The susceptible area is inspected with the pulsed eddy current sensor, which induces an eddy current in the inner wall of the equipment. Based on a rate of the decay in strength of the eddy current, it is determined whether corrosion exists at the susceptible area using a processor configured by code.
  • Device and method for microfluidics-based 3d bioprinting

    Hauser, Charlotte; Rauf, Sakandar (2018-11-15) [Patent]
    The present invention relates to a device and a method for building a 3D object by mixing a bioink solution, a buffer solution capable of inducing gelation of the bioink solution and a dispersion containing micro and/or nanoparticles, and ejecting the formed hydrogel out of a nozzle. The present invention further relates to a method of obtaining a hydrogel.
  • Genetically encoded biotin and biotin-analogs and use thereof

    Hohl, Adrian; Eppinger, Jörg (2018-11-15) [Patent]
    Embodiments of the present disclosure describe non-canonical amino acids characterized by the formula A—L—B, where A is an amino acid, L is a linker, and B is a biotin or a biotin-analog group. Embodiments describe translation systems comprising an orthogonal tRNA; an orthogonal aminoacyl-tRNA-synthetase, and a non- canonical amino acid with a biotin-containing side-chain or biotin-analog-containing side-chain; wherein the O-RS preferentially aminoacylates the O-tRNA with the non- canonical amino acid; wherein the non-canonical amino acid is incorporated into a protein at a specific site during translation
  • Strongarm latch comparator and method

    Almansouri, Abdullah Saud Mohammed; Al-Turki, Abdullah Turki; Al Attar, Talal (2018-11-08) [Patent]
    A StrongARM latch comparator (500) includes first and second p-type metal- oxide-semiconductor, PMOS, cross-coupled transistors (T1, T2); third and fourth n- type metal-oxide-semiconductor, NMOS, cross-coupled transistors (T3, T4), wherein the first PMOS cross-coupled transistor (T1) has a gate electrically coupled to a gate of the third NMOS cross-coupled transistor (T3) and the second PMOS cross- coupled transistor (T2) has a gate electrically coupled to a gate of the fourth NMOS cross-coupled transistor (T4); and fifth and sixth input transistors (T5, T6). The fifth input transistor (T5) is electrically connected between the first PMOS cross-coupled transistor (T1) and the third NMOS cross-coupled transistor (T3), and the sixth input transistor (T6) is electrically connected between the second PMOS cross-coupled transistor (T2) and the fourth NMOS cross-coupled transistor (T4).
  • Metal-organic materials (MOMs) for CO2 absorption and methods of using MOMs

    Eddaoudi, Mohamed; Zaworotko, Michael J.; Nugent, Patrick; Burd, Stephen; Belmabkhout, Youssef; Shekhah, Osama (2018-10-30) [Patent]
    Embodiments of the present disclosure provide for metal-organic materials (MOMs), systems that exhibit permanent porosity and using hydrophobic MOMs to separate components in a gas, methods of separating CO 2 from a gas, and the like.
  • Stochastic memristor logic devices

    Naous, Rawan; Salama, Khaled N. (2018-10-25) [Patent]
    In accordance with the present disclosure, one embodiment includes a memristor that is caused to be in a particular resistance state by a voltage applied across terminals of the memristor. A first logical input and a second logical input that are below a threshold voltage of the memristor are applied to a first terminal of the memristor. A first control input and a second control input are applied to a second terminal of the memristor. A logical output is determined based on a resistance state of the memristor.
  • Dual electro-mechanical oscillator for dynamically reprogrammable logic gate

    Nanaiah, Karumbaiah Chappanda; Younis, Mohammad I. (2018-10-25) [Patent]
    Embodiments include a logic gate system comprising a first micro-cantilever beam arranged in parallel to a second micro-cantilever beam in which a length of the first micro- cantilever beam is shorter than a length of the second micro-cantilever beam. The first micro-cantilever beam is adjacent to the second micro-cantilever beam and the first micro-cantilever beam is coupled to an input DC bias voltage source to the logic gate system. The second micro-cantilever beam is coupled to an input AC voltage signal that dynamically sets a logic operation of the logic gate system by at least changing an operating resonance frequency for one or more of the first micro-cantilever beam and the second micro-cantilever beam.
  • Method for determining heterologous biosynthesis pathways

    Gao, Xin; Kuwahara, Hiroyuki; Alazmi, Meshari Saud; Cui, Xuefeng (2018-10-24) [Patent]
    The present invention relates to a method and system for dynamically analyzing, determining, predicting and displaying ranked suitable heterologous biosynthesis pathways for a specified host. The present invention addresses the problem of finding suitable pathways for the endogenous metabolism of a host organism because the efficacy of heterologous biosynthesis is affected by competing endogenous pathways. The present invention is called MRE (Metabolic Route Explorer), and it was conceived and developed to systematically and dynamically search for, determine, analyze, and display promising heterologous pathways while considering competing endogenous reactions in a given host organism.
  • Energy storage by reversible inverse crystallization

    Saidaminov, Makhsud I.; Bakr, Osman; de Bastiani, Michele (2018-10-18) [Patent]
    Embodiments of the present disclosure describe a method of energy storage and release based on crystallization-dissolution comprising heating a solute-solvent system to decrease a solubility of a solute in the solvent and induce crystal formation; cooling a solute-solvent system to increase the solubility of the solute in the solvent and induce crystal dissolution; wherein energy is stored in the crystal upon heating and released from the crystal upon cooling.
  • Apparatus, system and method for inspecting composite structures using quantitative infra-red thermography

    Villette, Thibault; Traidia, Abderrazak; Amer, Ayman Mohamed Mahmoud; Abdel Latif, Fadl Hicham Fadl (2018-10-18) [Patent]
    A system and method for inspecting a surface of a structure for defects includes an inspection apparatus having a heating device for heating a section of the surface of the structure, an infrared camera for receiving infrared radiation from the surface in response to heating, a controller configured to generate thermographs from the received infrared radiation, and a communication device. A training system includes an expert system module configured to determine correlations between a set of thermographs generated by a thermal simulation of modeled structural elements with defects, and parameters of the modeled structural elements. A computer system communicatively coupled to the training system and the inspection apparatus, is adapted to receive thermographs received from the inspection apparatus and to detect quantitative parameters of defects in the structure using the correlations obtained from the training system.
  • Treated iron ore catalysts for production of hydrogen and graphene

    Basset, Jean-Marie; Zhou, Lu; ENAKONDA, Linga Reddy (2018-10-18) [Patent]
    Embodiments of the present disclosure describe a treated iron ore catalyst. Embodiments of the present disclosure further describe a method of preparing a treated iron ore catalyst comprising dehydrating an iron ore, milling the iron ore to a selected particle size, and reducing the iron ore to form a treated iron ore catalyst. Another embodiment of the present disclosure is a method of using a treated iron ore catalyst comprising contacting a feed gas with a treated iron ore catalyst to produce hydrogen and graphene.
  • Methods for controlling root parasitic weeds: inhibitors of seed germination in striga

    Al-Babili, Salim; AROLD, Stefan Theodor; Hameed, Umar Farook Shahul (2018-10-18) [Patent]
    Herbicides, systems, and methods for inhibiting germination of a root parasitic plant are provided. In particular, the herbicide includes an active compound represented by Formula 1. In this regard, the active compound is selected to bind to an active site of strigolactone receptors in seeds of the root parasitic plant.
  • Pop-up virtual reality viewer for an electronic display such as in a mobile device

    AL ZAYDI, Abdulwahid Awad; AL ZAYDI, Mohammed Awad (2018-10-11) [Patent]
    A virtual reality viewer may be integrated with printed materials, such as pamphlets, flyers, magazines, or books. A user may be able to review the printed material regarding the advertised products or services and then activate a virtual reality scene on an electronic display, such as the user's mobile device, that provides the user with more information regarding the products or services. The virtual reality viewer may be attached to pages in the printed materials and constructed in a manner such that the viewer pops up when the pages are opened. The user may place a mobile device in the viewer and/or access an integrated display to view a virtual reality scene related to content in the printed materials.
  • Achieving safe and stable anodes for li ion, li-s and li-air batteries: enhanced li +-solvent coordination in electrolytes

    Li, Lain-Jong; Ming, Jun (2018-10-11) [Patent]
    Lithium batteries, electrolytes configured for use in lithium batteries, and methods of preparing stable lithium batteries are provided. The electrolyte includes a lithium ion source, an ether-based solvent, and an inorganic salt represented by the formula MA, wherein M is selected from the group consisting of Li + , Na + , K + , Ca 2+ , Mg 2+ , and Al 3+ , and A is selected from the group consisting of F - , Cl - , Br - , I - , NO 3 \n - , SO 4 \n 2- , CO 3 \n 2- , and PO 4 \n 3- . In this regard, the inorganic salt provides coordination cores for lithium ion aggregation.
  • Methods of capturing of co2 and h2o

    Cadiau, Amandine; Adil, Karim; Belmabkhout, Youssef; Bhatt, Prashant; Eddaoudi, Mohamed (2018-10-11) [Patent]
    Embodiments of the present disclosure describe a method of capturing chemical species from a fluid composition comprising providing a metal-organic framework characterized by the formula M a M b F 5 (O/H 2 O)(pyrazine) 2 · x (solv), wherein M a is Ni 2+ ; M b is Nb 5+ , Al 3+ , or Fe 3+ ; x is from 0 to 10 and solv is one or more of H 2 O, CO 2 , DMF, EtOH, NMP, MeOH; contacting the metal-organic framework with a fluid composition including H 2 O, CO 2 , and one or more other chemical species; and capturing H 2 O and CO 2 simultaneously from the fluid composition.
  • Combustion arrester quantification systems and methods

    Damazo, Jason Scott; Lacoste, Deanna; Kwon, Eddie; Roberts, William Lafayette (2018-10-04) [Patent]
    Systems and methods for quantifying combustion arrester performance are disclosed. Methods include filling an upstream volume and a combustion arrester with a flammable gas, igniting the flammable gas in the upstream volume (and upstream of the combustion arrester), measuring a composition of gas discharged from the combustion arrester due to ignition of the flammable gas, and quantifying the performance of the combustion arrester based on the composition of gas measured. The measured gas composition may include types and/or amounts of combustion species within the gas discharged from the combustion arrester.
  • Combustion arrester test systems and methods

    Kwon, Eddie; Damazo, Jason Scott; Lacoste, Deanna; Roberts, William Lafayette (2018-10-04) [Patent]
    Systems, kits, and methods for testing a combustion arrester are disclosed. Systems include an upstream chamber, a downstream chamber, and a combustion arrester between the upstream chamber and the downstream chamber. The upstream chamber includes an ignition port configured to receive an ignition source. And, the upstream chamber defines a convergent duct that converges toward the combustion arrester and terminates at the combustion arrester. The upstream chamber may include a hierarchical series of modular shell sections that define the convergent duct. The downstream chamber may include a series of modular shell sections.
  • Rare earth-based metal-organic framework for moisture removal and control in confined spaces

    Eddaoudi, Mohamed; AbdulHalim, Rasha; Belmabkhout, Youssef (2018-10-04) [Patent]
    A method for preparing a metal-organic framework (MOF) comprising contacting one or more of a rare earth metal ion component with one or more of a tetratopic ligand component, sufficient to form a rare earth-based MOF for controlling moisture in an environment. A method of moisture control in an environment comprising adsorbing and/or desorbing water vapor in an environment using a MOF, the MOF including one or more of a rare earth metal ion component and one or more of a tetratopic ligand component. A method of controlling moisture in an environment comprising sensing the relative humidity in the environment comprising a MOF; and adsorbing water vapor on the MOF if the relative humidity is above a first level, sufficient to control moisture in an environment. The examples relate to a MOF created from 1,2,4,5-Tetrakis(4-carboxyphenyl)benzene (BTEB) as tetratopic ligand, 2-fluorobenzoic acid and Y(NO3)3, Tb(NO3)3 and Yb(NO3)3 as rare earth metals.
  • Compositions and methods for preparing cd34neg stem cells for transplant

    Merzaban, Jasmeen; Abu Samra, Dina Bashir Kamil; Al-Amoodi, Asma S. (2018-09-27) [Patent]
    It has been discovered that CD34 neg cells, for example HSPCs, can be modified to increase their ability to migrate and to engraft in bone marrow. One embodiment provides a method for modifying CD34 neg cells by using glycosyltransferase-programmed stereosubstitution (GPS) to create relevant selectin-binding glycan determinants on the cell surface. For example, the CD34 neg cells can be treated with a fucosyltransferase, such as an α(1,3)-linkage-specific fucosyltransferase. Representative enzymes that can be used include, but are not limited to fucosyltransferase VI (FTVI or FucT-6) or fucosyltransferase VII (FTVII of FucT-7). These enzymes specifically places a fucose onto a terminal type 2-lactosamine unit; if that lactosamine is capped with an α(2,3)-linked sialic acid, sLe x is created.

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