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    Comparative Proteomic Profiling of Mycobacterium bovis and BCG Vaccine Strains

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    Type
    Thesis
    Authors
    Gao, Ge
    Advisors
    Pain, Arnab cc
    Committee members
    Gehring, Christoph A cc
    Ravasi, Timothy cc
    Program
    Bioscience
    KAUST Department
    Biological and Environmental Science and Engineering (BESE) Division
    Date
    2013-09
    Permanent link to this record
    http://hdl.handle.net/10754/302495
    
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    Abstract
    BCG is the only licensed human vaccine currently available against TB. Derived from a virulent strain of M. bovis, the vaccine was thought to have struck a balance between reduced virulence and preserved immunogenicity. Nowadays, BCG vaccine strains used in different countries and vaccination programs show clear variations in their genomes and immune protective properties. The aim of this study was to characterize the proteomic profile on Mycobacterium bovis and five BCG strains Pasteur, Tokyo, Danish, Phipps and Birkhaug by Tandem Mass Tag® (TMT®)-labeling quantitative proteomic approach. In total, 420 proteins were identified and 377 of them were quantitated for their relative abundance. We reported the number and relationship of differential expressed proteins in BCG strains compared to M. bovis and investigated their functions by bioinformatics analysis. Several interesting up-regulated and down-regulated protein targets were found. The identified proteins and their quantitative expression profiles provide a basis for further understanding of the cellular biology of M. bovis and BCG vaccine strains, and hopefully would assist in the design of better anti-TB vaccine and drugs.
    Citation
    Gao, G. (2013). Comparative Proteomic Profiling of Mycobacterium bovis and BCG Vaccine Strains. KAUST Research Repository. https://doi.org/10.25781/KAUST-G5ZF4
    DOI
    10.25781/KAUST-G5ZF4
    ae974a485f413a2113503eed53cd6c53
    10.25781/KAUST-G5ZF4
    Scopus Count
    Collections
    Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; MS Theses

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