Show simple item record

dc.contributor.advisorPain, Arnab
dc.contributor.authorRamaprasad, Abhinay
dc.date.accessioned2012-10-14T09:07:37Z
dc.date.available2012-10-14T09:07:37Z
dc.date.issued2012-08
dc.identifier.citationRamaprasad, A. (2012). Studying Different Clinical Syndromes Of Paediatric Severe Malaria Using Plasma Proteomics. KAUST Research Repository. https://doi.org/10.25781/KAUST-1XW71
dc.identifier.doi10.25781/KAUST-1XW71
dc.identifier.urihttp://hdl.handle.net/10754/248732
dc.description.abstractBackground- Severe Plasmodium falciparum malaria remains one of the major causes of childhood morbidity and mortality in Africa. Severe malaria manifests itself as three main clinical syndromes-impaired consciousness (cerebral malaria), respiratory distress and severe malarial anaemia. Cerebral malaria and respiratory distress are major contributors to malaria mortality but their pathophysiology remains unclear. Motivation/Objectives- Most children with severe malaria die within the first 24 hours of admission to a hospital because of their pathophysiological conditions. Thus, along with anti-malarial drugs, various adjuvant therapies such as fluid bolus (for hypovolaemia) and anticonvulsants (for seizures) are given to alleviate the sick child’s condition. But these therapies can sometimes have adverse effects. Hence, a clear understanding of severe malaria pathophysiology is essential for making an informed decision regarding adjuvant therapies. Methodology- We used mass spectrometry-based shotgun proteomics to study plasma samples from Gambian children with severe malaria. We compared the proteomic profiles of different severe malaria syndromes and generated hypotheses regarding the underlying disease mechanisms. Results/Conclusions- The main challenges of studying the severe malaria syndromes using proteomics were the high complexity and variability among the samples. We hypothesized that hepatic injury and nitric oxide play roles in the pathophysiology of cerebral malaria and respiratory distress.
dc.language.isoen
dc.subjectMalaria
dc.subjectPlasma proteomics
dc.subjectpediatric malaria
dc.subjectplasmodium falciparum
dc.subjectmass spectrometry
dc.titleStudying Different Clinical Syndromes Of Paediatric Severe Malaria Using Plasma Proteomics
dc.typeThesis
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
thesis.degree.grantorKing Abdullah University of Science and Technology
dc.contributor.committeememberBajic, Vladimir B.
dc.contributor.committeememberCasals-Pascual, Climent
dc.contributor.committeememberRavasi, Timothy
thesis.degree.disciplineBioscience
thesis.degree.nameMaster of Science


Files in this item

Thumbnail
Name:
AbhinayRamaprasadThesis.pdf
Size:
1.765Mb
Format:
PDF
Thumbnail
Name:
AbhinayRamaprasadApproval.pdf
Size:
148.1Kb
Format:
PDF
Thumbnail
Name:
AbhinayRamaprasadCopyright.pdf
Size:
1.190Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record