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    Antimicrobial and Cytotoxic Activities of Extracts from Laurus nobilis Leaves

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    ShazaFelembanThesis.pdf
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    Type
    Thesis
    Authors
    Felemban, Shaza
    Advisors
    Minneman, Kenneth P.
    Committee members
    Altawashi, Azza
    Gehring, Christoph A cc
    Xiong, Liming cc
    Program
    Bioscience
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Date
    2011-05
    Permanent link to this record
    http://hdl.handle.net/10754/136195
    
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    Abstract
    The cytotoxic activity and antimicrobial properties of crude extracts from Laurus nobilis were investigated. With the use of the organic solvents, methanol and ethanol, crude extracts were obtained. To determine the availability of active bio-compounds, an analysis using liquid chromatography was conducted. The crude extract was also tested for antimicrobial activity. The disc diffusion method was used against the bacterium Escherichia coli. The results showed a weak antimicrobial activity against E. coli. For cytotoxicity testing, the crude extract was studied on four cell-­lines: human breast adenocarcinoma, human embryonic kidney, HeLa (human cervical adenocarcinoma), and human lung fibroblast. From the alamarBlue® assay results, the extracts most potently affected the cell-­lines of human breast adenocarcinoma and human embryonic kidney. Using the lactate dehydrogenase (LDH) assay, an effect on human embryonic kidney was most prominent. With these findings, a suggestion that the crude extract of Laurus nobilis may have antiproliferative properties is put forth, with the possibility of this mechanism being induction of apoptosis with the involvement of Nuclear Factor Kappa κB (NF κB).
    Citation
    Felemban, S. (2011). Antimicrobial and Cytotoxic Activities of Extracts from Laurus nobilis Leaves. KAUST Research Repository. https://doi.org/10.25781/KAUST-T1G40
    DOI
    10.25781/KAUST-T1G40
    ae974a485f413a2113503eed53cd6c53
    10.25781/KAUST-T1G40
    Scopus Count
    Collections
    Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program; Theses

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