The epigenetic landscape of transgenerational acclimation to ocean warming

Handle URI:
http://hdl.handle.net/10754/627866
Title:
The epigenetic landscape of transgenerational acclimation to ocean warming
Authors:
Ryu, Tae Woo; Veilleux, Heather D.; Donelson, Jennifer M.; Munday, Philip L. ( 0000-0001-9725-2498 ) ; Ravasi, Timothy ( 0000-0002-9950-465X )
Abstract:
Epigenetic inheritance is a potential mechanism by which the environment in one generation can influence the performance of future generations1. Rapid climate change threatens the survival of many organisms; however, recent studies show that some species can adjust to climate-related stress when both parents and their offspring experience the same environmental change2,3. Whether such transgenerational acclimation could have an epigenetic basis is unknown. Here, by sequencing the liver genome, methylomes and transcriptomes of the coral reef fish, Acanthochromis polyacanthus, exposed to current day (+0 °C) or future ocean temperatures (+3 °C) for one generation, two generations and incrementally across generations, we identified 2,467 differentially methylated regions (DMRs) and 1,870 associated genes that respond to higher temperatures within and between generations. Of these genes, 193 were significantly correlated to the transgenerationally acclimating phenotypic trait, aerobic scope, with functions in insulin response, energy homeostasis, mitochondrial activity, oxygen consumption and angiogenesis. These genes may therefore play a key role in restoring performance across generations in fish exposed to increased temperatures associated with climate change. Our study is the first to demonstrate a possible association between DNA methylation and transgenerational acclimation to climate change in a vertebrate.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division; Bioscience Program
Citation:
Ryu T, Veilleux HD, Donelson JM, Munday PL, Ravasi T (2018) The epigenetic landscape of transgenerational acclimation to ocean warming. Nature Climate Change. Available: http://dx.doi.org/10.1038/s41558-018-0159-0.
Publisher:
Springer Nature
Journal:
Nature Climate Change
KAUST Grant Number:
OCRF-2014-CRG3-62140408
Issue Date:
26-Apr-2018
DOI:
10.1038/s41558-018-0159-0
Type:
Article
ISSN:
1758-678X; 1758-6798
Sponsors:
This study was supported by the Competitive Research Funds OCRF-2014-CRG3-62140408 from the King Abdullah University of Science and Technology. This project was completed under JCU Ethics A1233 and A1415. T.Ryu acknowledges the support from the APEC Climate Center. P.L.M. was supported by the Australian Research Council (ARC) and P.L.M., H.D.V. and J.M.D. were supported by the ARC Centre of Excellence for Coral Reef Studies. We thank C. Ortiz Alvarez and E. J. Steinig (James Cook University) for assisting genomic DNA extraction for methylome sequencing. Figures were enhanced by I. Gromicho, scientific illustrator at King Abdullah University of Science and Technology (KAUST).
Additional Links:
https://www.nature.com/articles/s41558-018-0159-0
Appears in Collections:
Articles; Bioscience Program; Computational Bioscience Research Center (CBRC); Biological and Environmental Sciences and Engineering (BESE) Division; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorRyu, Tae Wooen
dc.contributor.authorVeilleux, Heather D.en
dc.contributor.authorDonelson, Jennifer M.en
dc.contributor.authorMunday, Philip L.en
dc.contributor.authorRavasi, Timothyen
dc.date.accessioned2018-05-14T13:37:07Z-
dc.date.available2018-05-14T13:37:07Z-
dc.date.issued2018-04-26en
dc.identifier.citationRyu T, Veilleux HD, Donelson JM, Munday PL, Ravasi T (2018) The epigenetic landscape of transgenerational acclimation to ocean warming. Nature Climate Change. Available: http://dx.doi.org/10.1038/s41558-018-0159-0.en
dc.identifier.issn1758-678Xen
dc.identifier.issn1758-6798en
dc.identifier.doi10.1038/s41558-018-0159-0en
dc.identifier.urihttp://hdl.handle.net/10754/627866-
dc.description.abstractEpigenetic inheritance is a potential mechanism by which the environment in one generation can influence the performance of future generations1. Rapid climate change threatens the survival of many organisms; however, recent studies show that some species can adjust to climate-related stress when both parents and their offspring experience the same environmental change2,3. Whether such transgenerational acclimation could have an epigenetic basis is unknown. Here, by sequencing the liver genome, methylomes and transcriptomes of the coral reef fish, Acanthochromis polyacanthus, exposed to current day (+0 °C) or future ocean temperatures (+3 °C) for one generation, two generations and incrementally across generations, we identified 2,467 differentially methylated regions (DMRs) and 1,870 associated genes that respond to higher temperatures within and between generations. Of these genes, 193 were significantly correlated to the transgenerationally acclimating phenotypic trait, aerobic scope, with functions in insulin response, energy homeostasis, mitochondrial activity, oxygen consumption and angiogenesis. These genes may therefore play a key role in restoring performance across generations in fish exposed to increased temperatures associated with climate change. Our study is the first to demonstrate a possible association between DNA methylation and transgenerational acclimation to climate change in a vertebrate.en
dc.description.sponsorshipThis study was supported by the Competitive Research Funds OCRF-2014-CRG3-62140408 from the King Abdullah University of Science and Technology. This project was completed under JCU Ethics A1233 and A1415. T.Ryu acknowledges the support from the APEC Climate Center. P.L.M. was supported by the Australian Research Council (ARC) and P.L.M., H.D.V. and J.M.D. were supported by the ARC Centre of Excellence for Coral Reef Studies. We thank C. Ortiz Alvarez and E. J. Steinig (James Cook University) for assisting genomic DNA extraction for methylome sequencing. Figures were enhanced by I. Gromicho, scientific illustrator at King Abdullah University of Science and Technology (KAUST).en
dc.publisherSpringer Natureen
dc.relation.urlhttps://www.nature.com/articles/s41558-018-0159-0en
dc.titleThe epigenetic landscape of transgenerational acclimation to ocean warmingen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.contributor.departmentBioscience Programen
dc.identifier.journalNature Climate Changeen
dc.contributor.institutionAPEC Climate Center, Busan, South Koreaen
dc.contributor.institutionARC Centre of Excellence for Coral Reef Studies, James Cook University, Townsville, Queensland, Australiaen
dc.contributor.institutionSchool of Life Sciences, University of Technology Sydney, Broadway, New South Wales, Australiaen
kaust.authorRyu, Tae Wooen
kaust.authorRavasi, Timothyen
kaust.grant.numberOCRF-2014-CRG3-62140408en
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