Deconstructing the pluripotency gene regulatory network

Handle URI:
http://hdl.handle.net/10754/627625
Title:
Deconstructing the pluripotency gene regulatory network
Authors:
Li, Mo ( 0000-0003-0827-8907 ) ; Izpisua Belmonte, Juan Carlos ( 0000-0003-0557-8875 )
Abstract:
Pluripotent stem cells can be isolated from embryos or derived by reprogramming. Pluripotency is stabilized by an interconnected network of pluripotency genes that cooperatively regulate gene expression. Here we describe the molecular principles of pluripotency gene function and highlight post-transcriptional controls, particularly those induced by RNA-binding proteins and alternative splicing, as an important regulatory layer of pluripotency. We also discuss heterogeneity in pluripotency regulation, alternative pluripotency states and future directions of pluripotent stem cell research.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program
Citation:
Li M, Izpisua Belmonte JC (2018) Deconstructing the pluripotency gene regulatory network. Nature Cell Biology 20: 382–392. Available: http://dx.doi.org/10.1038/s41556-018-0067-6.
Publisher:
Springer Nature
Journal:
Nature Cell Biology
Issue Date:
4-Apr-2018
DOI:
10.1038/s41556-018-0067-6
Type:
Article
ISSN:
1465-7392; 1476-4679
Sponsors:
We apologize to the colleagues whose works are not covered due to space constraint. We would like to thank May Schwarz, Peter Schwarz, Chunmei Xia and Xingxing Zhang for generous administrative help during the preparation of the manuscript. We would like to thank the anonymous reviewers whose input has resulted in an improved manuscript. Work in the laboratory of M.L. was supported by King Abdullah University of Science and Technology (KAUST). Work in the laboratory of J.C.I.B. was supported by the G. Harold and Leila Y. Mathers Charitable Foundation, The Leona M. and Harry B. Helmsley Charitable Trust (2012-PG-MED002), the Moxie Foundation, NIH (5 DP1 DK113616 and R21AG055938), Progeria Research Foundation, Fundacion Dr. Pedro Guillen and the Universidad Católica San Antonio de Murcia (UCAM).
Additional Links:
https://www.nature.com/articles/s41556-018-0067-6
Appears in Collections:
Articles; Bioscience Program; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorLi, Moen
dc.contributor.authorIzpisua Belmonte, Juan Carlosen
dc.date.accessioned2018-04-24T07:48:28Z-
dc.date.available2018-04-24T07:48:28Z-
dc.date.issued2018-04-04en
dc.identifier.citationLi M, Izpisua Belmonte JC (2018) Deconstructing the pluripotency gene regulatory network. Nature Cell Biology 20: 382–392. Available: http://dx.doi.org/10.1038/s41556-018-0067-6.en
dc.identifier.issn1465-7392en
dc.identifier.issn1476-4679en
dc.identifier.doi10.1038/s41556-018-0067-6en
dc.identifier.urihttp://hdl.handle.net/10754/627625-
dc.description.abstractPluripotent stem cells can be isolated from embryos or derived by reprogramming. Pluripotency is stabilized by an interconnected network of pluripotency genes that cooperatively regulate gene expression. Here we describe the molecular principles of pluripotency gene function and highlight post-transcriptional controls, particularly those induced by RNA-binding proteins and alternative splicing, as an important regulatory layer of pluripotency. We also discuss heterogeneity in pluripotency regulation, alternative pluripotency states and future directions of pluripotent stem cell research.en
dc.description.sponsorshipWe apologize to the colleagues whose works are not covered due to space constraint. We would like to thank May Schwarz, Peter Schwarz, Chunmei Xia and Xingxing Zhang for generous administrative help during the preparation of the manuscript. We would like to thank the anonymous reviewers whose input has resulted in an improved manuscript. Work in the laboratory of M.L. was supported by King Abdullah University of Science and Technology (KAUST). Work in the laboratory of J.C.I.B. was supported by the G. Harold and Leila Y. Mathers Charitable Foundation, The Leona M. and Harry B. Helmsley Charitable Trust (2012-PG-MED002), the Moxie Foundation, NIH (5 DP1 DK113616 and R21AG055938), Progeria Research Foundation, Fundacion Dr. Pedro Guillen and the Universidad Católica San Antonio de Murcia (UCAM).en
dc.publisherSpringer Natureen
dc.relation.urlhttps://www.nature.com/articles/s41556-018-0067-6en
dc.titleDeconstructing the pluripotency gene regulatory networken
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentBioscience Programen
dc.identifier.journalNature Cell Biologyen
dc.contributor.institutionSalk Institute for Biological Studies, San Digo, CA, , United Statesen
kaust.authorLi, Moen
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