CRISPR/Cas13 as a Tool for RNA Interference

Handle URI:
http://hdl.handle.net/10754/627624
Title:
CRISPR/Cas13 as a Tool for RNA Interference
Authors:
Ali, Zahir ( 0000-0002-7814-8908 ) ; Mahas, Ahmed; Mahfouz, Magdy M. ( 0000-0002-0616-6365 )
Abstract:
Almost all biological processes involve RNA, making it crucial to develop tools for manipulation of the transcriptome. The bacterial CRISPR/Cas13 system was recently rewired to facilitate RNA manipulation in eukaryotes, including plants. We discuss here the opportunities and limitations of using CRISPR/Cas13 in plants for various types of RNA manipulation.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program; Desert Agriculture Initiative; Laboratory for Genome Engineering
Citation:
Ali Z, Mahas A, Mahfouz M (2018) CRISPR/Cas13 as a Tool for RNA Interference. Trends in Plant Science 23: 374–378. Available: http://dx.doi.org/10.1016/j.tplants.2018.03.003.
Publisher:
Elsevier BV
Journal:
Trends in Plant Science
KAUST Grant Number:
OSR-2015-CRG4-2647
Issue Date:
28-Mar-2018
DOI:
10.1016/j.tplants.2018.03.003
Type:
Article
ISSN:
1360-1385
Sponsors:
We wish to thank the Office of Sponsored Research (OSR) and King Abdullah University of Science and Technology (KAUST) for their support (award OSR-2015-CRG4-2647).
Additional Links:
http://www.sciencedirect.com/science/article/pii/S1360138518300451
Appears in Collections:
Articles; Bioscience Program; Desert Agriculture Initiative; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorAli, Zahiren
dc.contributor.authorMahas, Ahmeden
dc.contributor.authorMahfouz, Magdy M.en
dc.date.accessioned2018-04-24T07:48:28Z-
dc.date.available2018-04-24T07:48:28Z-
dc.date.issued2018-03-28en
dc.identifier.citationAli Z, Mahas A, Mahfouz M (2018) CRISPR/Cas13 as a Tool for RNA Interference. Trends in Plant Science 23: 374–378. Available: http://dx.doi.org/10.1016/j.tplants.2018.03.003.en
dc.identifier.issn1360-1385en
dc.identifier.doi10.1016/j.tplants.2018.03.003en
dc.identifier.urihttp://hdl.handle.net/10754/627624-
dc.description.abstractAlmost all biological processes involve RNA, making it crucial to develop tools for manipulation of the transcriptome. The bacterial CRISPR/Cas13 system was recently rewired to facilitate RNA manipulation in eukaryotes, including plants. We discuss here the opportunities and limitations of using CRISPR/Cas13 in plants for various types of RNA manipulation.en
dc.description.sponsorshipWe wish to thank the Office of Sponsored Research (OSR) and King Abdullah University of Science and Technology (KAUST) for their support (award OSR-2015-CRG4-2647).en
dc.publisherElsevier BVen
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S1360138518300451en
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Trends in Plant Science. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Trends in Plant Science, [, , (2018-03-28)] DOI: 10.1016/j.tplants.2018.03.003 . © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectCRISPR/Cas13en
dc.subjectRNA manipulationen
dc.subjecttranscriptome regulationen
dc.subjectviral interferenceen
dc.titleCRISPR/Cas13 as a Tool for RNA Interferenceen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentBioscience Programen
dc.contributor.departmentDesert Agriculture Initiativeen
dc.contributor.departmentLaboratory for Genome Engineeringen
dc.identifier.journalTrends in Plant Scienceen
dc.eprint.versionPost-printen
kaust.authorAli, Zahiren
kaust.authorMahas, Ahmeden
kaust.authorMahfouz, Magdy M.en
kaust.grant.numberOSR-2015-CRG4-2647en
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