Lactate in the brain: from metabolic end-product to signalling molecule

Handle URI:
http://hdl.handle.net/10754/627454
Title:
Lactate in the brain: from metabolic end-product to signalling molecule
Authors:
Magistretti, Pierre J. ( 0000-0002-6678-320X ) ; Allaman, Igor
Abstract:
Lactate in the brain has long been associated with ischaemia; however, more recent evidence shows that it can be found there under physiological conditions. In the brain, lactate is formed predominantly in astrocytes from glucose or glycogen in response to neuronal activity signals. Thus, neurons and astrocytes show tight metabolic coupling. Lactate is transferred from astrocytes to neurons to match the neuronal energetic needs, and to provide signals that modulate neuronal functions, including excitability, plasticity and memory consolidation. In addition, lactate affects several homeostatic functions. Overall, lactate ensures adequate energy supply, modulates neuronal excitability levels and regulates adaptive functions in order to set the 'homeostatic tone' of the nervous system.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program; King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.
Citation:
Magistretti PJ, Allaman I (2018) Lactate in the brain: from metabolic end-product to signalling molecule. Nature Reviews Neuroscience 19: 235–249. Available: http://dx.doi.org/10.1038/nrn.2018.19.
Publisher:
Springer Nature
Journal:
Nature Reviews Neuroscience
Issue Date:
8-Mar-2018
DOI:
10.1038/nrn.2018.19
Type:
Article
ISSN:
1471-003X; 1471-0048
Sponsors:
Research in P.J.M.'s laboratory has been supported over the years by the Swiss National Science Foundation, King Abdullah University of Science and Technology (KAUST; Saudi Arabia), the University of Lausanne (UNIL; Switzerland), École Polytechnique Fédérale de Lausanne (EPFL; Switzerland), Centre Hospitalier Universitaire Vaudois (CHUV; Switzerland), the National Centre for Competence in Research (NCCR) Synapsy and the Préfargier Foundation. The authors thank H. Fiumelli and F. Barros for comments on the manuscript.
Additional Links:
https://www.nature.com/articles/nrn.2018.19
Appears in Collections:
Articles; Bioscience Program; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorMagistretti, Pierre J.en
dc.contributor.authorAllaman, Igoren
dc.date.accessioned2018-04-15T07:13:35Z-
dc.date.available2018-04-15T07:13:35Z-
dc.date.issued2018-03-08en
dc.identifier.citationMagistretti PJ, Allaman I (2018) Lactate in the brain: from metabolic end-product to signalling molecule. Nature Reviews Neuroscience 19: 235–249. Available: http://dx.doi.org/10.1038/nrn.2018.19.en
dc.identifier.issn1471-003Xen
dc.identifier.issn1471-0048en
dc.identifier.doi10.1038/nrn.2018.19en
dc.identifier.urihttp://hdl.handle.net/10754/627454-
dc.description.abstractLactate in the brain has long been associated with ischaemia; however, more recent evidence shows that it can be found there under physiological conditions. In the brain, lactate is formed predominantly in astrocytes from glucose or glycogen in response to neuronal activity signals. Thus, neurons and astrocytes show tight metabolic coupling. Lactate is transferred from astrocytes to neurons to match the neuronal energetic needs, and to provide signals that modulate neuronal functions, including excitability, plasticity and memory consolidation. In addition, lactate affects several homeostatic functions. Overall, lactate ensures adequate energy supply, modulates neuronal excitability levels and regulates adaptive functions in order to set the 'homeostatic tone' of the nervous system.en
dc.description.sponsorshipResearch in P.J.M.'s laboratory has been supported over the years by the Swiss National Science Foundation, King Abdullah University of Science and Technology (KAUST; Saudi Arabia), the University of Lausanne (UNIL; Switzerland), École Polytechnique Fédérale de Lausanne (EPFL; Switzerland), Centre Hospitalier Universitaire Vaudois (CHUV; Switzerland), the National Centre for Competence in Research (NCCR) Synapsy and the Préfargier Foundation. The authors thank H. Fiumelli and F. Barros for comments on the manuscript.en
dc.publisherSpringer Natureen
dc.relation.urlhttps://www.nature.com/articles/nrn.2018.19en
dc.titleLactate in the brain: from metabolic end-product to signalling moleculeen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentBioscience Programen
dc.contributor.departmentKing Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.en
dc.identifier.journalNature Reviews Neuroscienceen
dc.contributor.institutionBrain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.en
kaust.authorMagistretti, Pierre J.en
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