Cooperative Assembly of Magneto-Nanovesicles with Tunable Wall Thickness and Permeability for MRI-Guided Drug Delivery

Handle URI:
http://hdl.handle.net/10754/627445
Title:
Cooperative Assembly of Magneto-Nanovesicles with Tunable Wall Thickness and Permeability for MRI-Guided Drug Delivery
Authors:
Yang, Kuikun; Liu, Yijing; Liu, Yi; Zhang, Qian; Kong, Chuncai ( 0000-0002-7144-4501 ) ; Yi, Chenglin; Zhou, Zijian; Wang, Zhantong; Zhang, Guofeng; Zhang, Yang; Khashab, Niveen M. ( 0000-0003-2728-0666 ) ; Chen, Xiaoyuan; Nie, Zhihong ( 0000-0001-9639-905X )
Abstract:
This article describes the fabrication of nanosized magneto-vesicles (MVs) comprising tunable layers of densely packed superparamagnetic iron oxide nanoparticles (SPIONs) in membranes via cooperative assembly of polymer-tethered SPIONs and free poly(styrene)- b-poly(acrylic acid) (PS- b-PAA). The membrane thickness of MVs could be well controlled from 9.8 to 93.2 nm by varying the weight ratio of PS- b-PAA to SPIONs. The increase in membrane thickness was accompanied by the transition from monolayer MVs, to double-layered MVs and to multilayered MVs (MuMVs). This can be attributed to the variation in the hydrophobic/hydrophilic balance of polymer-grafted SPIONs upon the insertion and binding of PS- b-PAA onto the surface of nanoparticles. Therapeutic agents can be efficiently encapsulated in the hollow cavity of MVs and the release of payload can be tuned by varying the membrane thickness of nanovesicles. Due to the high packing density of SPIONs, the MuMVs showed the highest magnetization and transverse relaxivity rate ( r2) in magnetic resonance imaging (MRI) among these MVs and individual SPIONs. Upon intravenous injection, doxorubicin-loaded MuMVs conjugated with RGD peptides could be effectively enriched at tumor sites due to synergetic effect of magnetic and active targeting. As a result, they exhibited drastically enhanced signal in MRI, improved tumor delivery efficiency of drugs as well as enhanced antitumor efficacy, compared with groups with only magnetic or active targeting strategy. The unique nanoplatform may find applications in effective disease control by delivering imaging and therapy to organs/tissues that are not readily accessible by conventional delivery vehicles.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program; Physical Sciences and Engineering (PSE) Division; Chemical Science Program; Advanced Membranes and Porous Materials Research Center; Smart Hybrid Materials (SHMs) lab
Citation:
Yang K, Liu Y, Liu Y, Zhang Q, Kong C, et al. (2018) Cooperative Assembly of Magneto-Nanovesicles with Tunable Wall Thickness and Permeability for MRI-Guided Drug Delivery. Journal of the American Chemical Society 140: 4666–4677. Available: http://dx.doi.org/10.1021/jacs.8b00884.
Publisher:
American Chemical Society (ACS)
Journal:
Journal of the American Chemical Society
KAUST Grant Number:
CRG-2015
Issue Date:
15-Mar-2018
DOI:
10.1021/jacs.8b00884
Type:
Article
ISSN:
0002-7863; 1520-5126
Sponsors:
Z.N. gratefully acknowledges the financial support of the National Science Foundation (grants: DMR-1255377 and CHE-1505839). N.M.K. and Z.N. further acknowledge the support provided by King Abdullah University of Science and Technology CRG-2015 grant. The work was also supported by the Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health as well as the National Natural Science Foundation of China (31771036) and the Basic Research Program of Shenzhen (JCYJ20160422091238319). We also acknowledge the support of the Maryland NanoCenter and its AIMLab.
Additional Links:
https://pubs.acs.org/doi/10.1021/jacs.8b00884
Appears in Collections:
Articles; Bioscience Program; Advanced Membranes and Porous Materials Research Center; Physical Sciences and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Chemical Science Program; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorYang, Kuikunen
dc.contributor.authorLiu, Yijingen
dc.contributor.authorLiu, Yien
dc.contributor.authorZhang, Qianen
dc.contributor.authorKong, Chuncaien
dc.contributor.authorYi, Chenglinen
dc.contributor.authorZhou, Zijianen
dc.contributor.authorWang, Zhantongen
dc.contributor.authorZhang, Guofengen
dc.contributor.authorZhang, Yangen
dc.contributor.authorKhashab, Niveen M.en
dc.contributor.authorChen, Xiaoyuanen
dc.contributor.authorNie, Zhihongen
dc.date.accessioned2018-04-15T07:13:34Z-
dc.date.available2018-04-15T07:13:34Z-
dc.date.issued2018-03-15en
dc.identifier.citationYang K, Liu Y, Liu Y, Zhang Q, Kong C, et al. (2018) Cooperative Assembly of Magneto-Nanovesicles with Tunable Wall Thickness and Permeability for MRI-Guided Drug Delivery. Journal of the American Chemical Society 140: 4666–4677. Available: http://dx.doi.org/10.1021/jacs.8b00884.en
dc.identifier.issn0002-7863en
dc.identifier.issn1520-5126en
dc.identifier.doi10.1021/jacs.8b00884en
dc.identifier.urihttp://hdl.handle.net/10754/627445-
dc.description.abstractThis article describes the fabrication of nanosized magneto-vesicles (MVs) comprising tunable layers of densely packed superparamagnetic iron oxide nanoparticles (SPIONs) in membranes via cooperative assembly of polymer-tethered SPIONs and free poly(styrene)- b-poly(acrylic acid) (PS- b-PAA). The membrane thickness of MVs could be well controlled from 9.8 to 93.2 nm by varying the weight ratio of PS- b-PAA to SPIONs. The increase in membrane thickness was accompanied by the transition from monolayer MVs, to double-layered MVs and to multilayered MVs (MuMVs). This can be attributed to the variation in the hydrophobic/hydrophilic balance of polymer-grafted SPIONs upon the insertion and binding of PS- b-PAA onto the surface of nanoparticles. Therapeutic agents can be efficiently encapsulated in the hollow cavity of MVs and the release of payload can be tuned by varying the membrane thickness of nanovesicles. Due to the high packing density of SPIONs, the MuMVs showed the highest magnetization and transverse relaxivity rate ( r2) in magnetic resonance imaging (MRI) among these MVs and individual SPIONs. Upon intravenous injection, doxorubicin-loaded MuMVs conjugated with RGD peptides could be effectively enriched at tumor sites due to synergetic effect of magnetic and active targeting. As a result, they exhibited drastically enhanced signal in MRI, improved tumor delivery efficiency of drugs as well as enhanced antitumor efficacy, compared with groups with only magnetic or active targeting strategy. The unique nanoplatform may find applications in effective disease control by delivering imaging and therapy to organs/tissues that are not readily accessible by conventional delivery vehicles.en
dc.description.sponsorshipZ.N. gratefully acknowledges the financial support of the National Science Foundation (grants: DMR-1255377 and CHE-1505839). N.M.K. and Z.N. further acknowledge the support provided by King Abdullah University of Science and Technology CRG-2015 grant. The work was also supported by the Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health as well as the National Natural Science Foundation of China (31771036) and the Basic Research Program of Shenzhen (JCYJ20160422091238319). We also acknowledge the support of the Maryland NanoCenter and its AIMLab.en
dc.publisherAmerican Chemical Society (ACS)en
dc.relation.urlhttps://pubs.acs.org/doi/10.1021/jacs.8b00884en
dc.titleCooperative Assembly of Magneto-Nanovesicles with Tunable Wall Thickness and Permeability for MRI-Guided Drug Deliveryen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentBioscience Programen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentChemical Science Programen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.identifier.journalJournal of the American Chemical Societyen
dc.contributor.institutionDepartment of Chemistry and Biochemistry, University of Maryland College Park, Maryland 20742, United Statesen
dc.contributor.institutionLaboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Maryland 20892, United Statesen
dc.contributor.institutionLiu, Yijingen
kaust.authorZhang, Yangen
kaust.authorKhashab, Niveen M.en
kaust.grant.numberCRG-2015en
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