How Polycomb-Mediated Cell Memory Deals With a Changing Environment

Handle URI:
http://hdl.handle.net/10754/627331
Title:
How Polycomb-Mediated Cell Memory Deals With a Changing Environment
Authors:
Marasca, Federica; Bodega, Beatrice; Orlando, Valerio ( 0000-0002-4906-8511 )
Abstract:
Cells and tissues are continuously exposed to a changing microenvironment, hence the necessity of a flexible modulation of gene expression that in complex organism have been achieved through specialized chromatin mechanisms. Chromatin-based cell memory enables cells to maintain their identity by fixing lineage specific transcriptional programs, ensuring their faithful transmission through cell division; in particular PcG-based memory system evolved to maintain the silenced state of developmental and cell cycle genes. In evolution the complexity of this system have increased, particularly in vertebrates, indicating combinatorial and dynamic properties of Polycomb proteins, in some cases even overflowing outside the cell nucleus. Therefore, their function may not be limited to the imposition of rigid states of genetic programs, but on the ability to recognize signals and allow plastic transcriptional changes in response to different stimuli. Here, we discuss the most novel PcG mediated memory functions in facing and responding to the challenges posed by a fluctuating environment.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program
Citation:
Marasca F, Bodega B, Orlando V (2018) How Polycomb-Mediated Cell Memory Deals With a Changing Environment. BioEssays: 1700137. Available: http://dx.doi.org/10.1002/bies.201700137.
Publisher:
Wiley-Blackwell
Journal:
BioEssays
Issue Date:
9-Mar-2018
DOI:
10.1002/bies.201700137
Type:
Article
ISSN:
0265-9247
Sponsors:
Beatrice Bodega and Valerio Orlando contributed equally to this work. We thank Chiara Lanzuolo and Alice Cortesi for helpful comments and criticisms on the manuscript. The work is supported by EPIGEN Italian flagship program (to BB), Istituto Nazionale di Genetica Molecolare to BB and King Abdullah University of Science and Technology (KAUST) to VO.
Additional Links:
http://onlinelibrary.wiley.com/doi/10.1002/bies.201700137/full
Appears in Collections:
Articles; Bioscience Program; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorMarasca, Federicaen
dc.contributor.authorBodega, Beatriceen
dc.contributor.authorOrlando, Valerioen
dc.date.accessioned2018-03-15T11:35:53Z-
dc.date.available2018-03-15T11:35:53Z-
dc.date.issued2018-03-09en
dc.identifier.citationMarasca F, Bodega B, Orlando V (2018) How Polycomb-Mediated Cell Memory Deals With a Changing Environment. BioEssays: 1700137. Available: http://dx.doi.org/10.1002/bies.201700137.en
dc.identifier.issn0265-9247en
dc.identifier.doi10.1002/bies.201700137en
dc.identifier.urihttp://hdl.handle.net/10754/627331-
dc.description.abstractCells and tissues are continuously exposed to a changing microenvironment, hence the necessity of a flexible modulation of gene expression that in complex organism have been achieved through specialized chromatin mechanisms. Chromatin-based cell memory enables cells to maintain their identity by fixing lineage specific transcriptional programs, ensuring their faithful transmission through cell division; in particular PcG-based memory system evolved to maintain the silenced state of developmental and cell cycle genes. In evolution the complexity of this system have increased, particularly in vertebrates, indicating combinatorial and dynamic properties of Polycomb proteins, in some cases even overflowing outside the cell nucleus. Therefore, their function may not be limited to the imposition of rigid states of genetic programs, but on the ability to recognize signals and allow plastic transcriptional changes in response to different stimuli. Here, we discuss the most novel PcG mediated memory functions in facing and responding to the challenges posed by a fluctuating environment.en
dc.description.sponsorshipBeatrice Bodega and Valerio Orlando contributed equally to this work. We thank Chiara Lanzuolo and Alice Cortesi for helpful comments and criticisms on the manuscript. The work is supported by EPIGEN Italian flagship program (to BB), Istituto Nazionale di Genetica Molecolare to BB and King Abdullah University of Science and Technology (KAUST) to VO.en
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/bies.201700137/fullen
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.titleHow Polycomb-Mediated Cell Memory Deals With a Changing Environmenten
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentBioscience Programen
dc.identifier.journalBioEssaysen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionIstituto Nazionale di Genetica Molecolare (INGM) “Romeo and Enrica Invernizzi”; Milan 20122 Italyen
kaust.authorOrlando, Valerioen
All Items in KAUST are protected by copyright, with all rights reserved, unless otherwise indicated.