Liquid–Solid Dual-Gate Organic Transistors with Tunable Threshold Voltage for Cell Sensing

Handle URI:
http://hdl.handle.net/10754/626628
Title:
Liquid–Solid Dual-Gate Organic Transistors with Tunable Threshold Voltage for Cell Sensing
Authors:
Zhang, Yu; Li, Jun; Li, Rui; Sbircea, Dan-Tiberiu; Giovannitti, Alexander; Xu, Junling; Xu, Huihua; Zhou, Guodong; Bian, Liming ( 0000-0003-4739-0918 ) ; McCulloch, Iain ( 0000-0002-6340-7217 ) ; Zhao, Ni ( 0000-0002-1536-8516 )
Abstract:
Liquid electrolyte-gated organic field effect transistors and organic electrochemical transistors have recently emerged as powerful technology platforms for sensing and simulation of living cells and organisms. For such applications, the transistors are operated at a gate voltage around or below 0.3 V because prolonged application of a higher voltage bias can lead to membrane rupturing and cell death. This constraint often prevents the operation of the transistors at their maximum transconductance or most sensitive regime. Here, we exploit a solid–liquid dual-gate organic transistor structure, where the threshold voltage of the liquid-gated conduction channel is controlled by an additional gate that is separated from the channel by a metal-oxide gate dielectric. With this design, the threshold voltage of the “sensing channel” can be linearly tuned in a voltage window exceeding 0.4 V. We have demonstrated that the dual-gate structure enables a much better sensor response to the detachment of human mesenchymal stem cells. In general, the capability of tuning the optimal sensing bias will not only improve the device performance but also broaden the material selection for cell-based organic bioelectronics.
KAUST Department:
KAUST Solar Center (KSC)
Citation:
Zhang Y, Li J, Li R, Sbircea D-T, Giovannitti A, et al. (2017) Liquid–Solid Dual-Gate Organic Transistors with Tunable Threshold Voltage for Cell Sensing. ACS Applied Materials & Interfaces 9: 38687–38694. Available: http://dx.doi.org/10.1021/acsami.7b09384.
Publisher:
American Chemical Society (ACS)
Journal:
ACS Applied Materials & Interfaces
Issue Date:
17-Oct-2017
DOI:
10.1021/acsami.7b09384
Type:
Article
ISSN:
1944-8244; 1944-8252
Sponsors:
We gratefully acknowledge funding from the Research Grant Council of Hong Kong (grant no. CUHK14218716).
Additional Links:
http://pubs.acs.org/doi/10.1021/acsami.7b09384
Appears in Collections:
Articles; KAUST Solar Center (KSC)

Full metadata record

DC FieldValue Language
dc.contributor.authorZhang, Yuen
dc.contributor.authorLi, Junen
dc.contributor.authorLi, Ruien
dc.contributor.authorSbircea, Dan-Tiberiuen
dc.contributor.authorGiovannitti, Alexanderen
dc.contributor.authorXu, Junlingen
dc.contributor.authorXu, Huihuaen
dc.contributor.authorZhou, Guodongen
dc.contributor.authorBian, Limingen
dc.contributor.authorMcCulloch, Iainen
dc.contributor.authorZhao, Nien
dc.date.accessioned2018-01-01T12:19:04Z-
dc.date.available2018-01-01T12:19:04Z-
dc.date.issued2017-10-17en
dc.identifier.citationZhang Y, Li J, Li R, Sbircea D-T, Giovannitti A, et al. (2017) Liquid–Solid Dual-Gate Organic Transistors with Tunable Threshold Voltage for Cell Sensing. ACS Applied Materials & Interfaces 9: 38687–38694. Available: http://dx.doi.org/10.1021/acsami.7b09384.en
dc.identifier.issn1944-8244en
dc.identifier.issn1944-8252en
dc.identifier.doi10.1021/acsami.7b09384en
dc.identifier.urihttp://hdl.handle.net/10754/626628-
dc.description.abstractLiquid electrolyte-gated organic field effect transistors and organic electrochemical transistors have recently emerged as powerful technology platforms for sensing and simulation of living cells and organisms. For such applications, the transistors are operated at a gate voltage around or below 0.3 V because prolonged application of a higher voltage bias can lead to membrane rupturing and cell death. This constraint often prevents the operation of the transistors at their maximum transconductance or most sensitive regime. Here, we exploit a solid–liquid dual-gate organic transistor structure, where the threshold voltage of the liquid-gated conduction channel is controlled by an additional gate that is separated from the channel by a metal-oxide gate dielectric. With this design, the threshold voltage of the “sensing channel” can be linearly tuned in a voltage window exceeding 0.4 V. We have demonstrated that the dual-gate structure enables a much better sensor response to the detachment of human mesenchymal stem cells. In general, the capability of tuning the optimal sensing bias will not only improve the device performance but also broaden the material selection for cell-based organic bioelectronics.en
dc.description.sponsorshipWe gratefully acknowledge funding from the Research Grant Council of Hong Kong (grant no. CUHK14218716).en
dc.publisherAmerican Chemical Society (ACS)en
dc.relation.urlhttp://pubs.acs.org/doi/10.1021/acsami.7b09384en
dc.subjectcell sensingen
dc.subjectdual-gateen
dc.subjectelectrolyte-gated organic field effect transistoren
dc.subjectorganic electrochemical transistoren
dc.subjectthreshold voltage tuningen
dc.titleLiquid–Solid Dual-Gate Organic Transistors with Tunable Threshold Voltage for Cell Sensingen
dc.typeArticleen
dc.contributor.departmentKAUST Solar Center (KSC)en
dc.identifier.journalACS Applied Materials & Interfacesen
dc.contributor.institutionDepartment of Electronic Engineering, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kongen
dc.contributor.institutionDepartment of Chemistry and Centre for Plastic Electronics, Imperial College, London SW7 2AZ, U.K.en
dc.contributor.institutionDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kongen
kaust.authorMcCulloch, Iainen
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