Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications

Handle URI:
http://hdl.handle.net/10754/626577
Title:
Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications
Authors:
Croissant, Jonas G.; Fatieiev, Yevhen ( 0000-0002-2844-8427 ) ; Almalik, Abdulaziz; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
Predetermining the physico-chemical properties, biosafety, and stimuli-responsiveness of nanomaterials in biological environments is essential for safe and effective biomedical applications. At the forefront of biomedical research, mesoporous silica nanoparticles and mesoporous organosilica nanoparticles are increasingly investigated to predict their biological outcome by materials design. In this review, it is first chronicled that how the nanomaterial design of pure silica, partially hybridized organosilica, and fully hybridized organosilica (periodic mesoporous organosilicas) governs not only the physico-chemical properties but also the biosafety of the nanoparticles. The impact of the hybridization on the biocompatibility, protein corona, biodistribution, biodegradability, and clearance of the silica-based particles is described. Then, the influence of the surface engineering, the framework hybridization, as well as the morphology of the particles, on the ability to load and controllably deliver drugs under internal biological stimuli (e.g., pH, redox, enzymes) and external noninvasive stimuli (e.g., light, magnetic, ultrasound) are presented. To conclude, trends in the biomedical applications of silica and organosilica nanovectors are delineated, such as unconventional bioimaging techniques, large cargo delivery, combination therapy, gaseous molecule delivery, antimicrobial protection, and Alzheimer's disease therapy.
KAUST Department:
Advanced Membranes and Porous Materials Research Center; Smart Hybrid Materials (SHMs) lab
Citation:
Croissant JG, Fatieiev Y, Almalik A, Khashab NM (2017) Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications. Advanced Healthcare Materials: 1700831. Available: http://dx.doi.org/10.1002/adhm.201700831.
Publisher:
Wiley-Blackwell
Journal:
Advanced Healthcare Materials
Issue Date:
30-Nov-2017
DOI:
10.1002/adhm.201700831
PubMed ID:
29193848
Type:
Article
ISSN:
2192-2640
Additional Links:
http://onlinelibrary.wiley.com/doi/10.1002/adhm.201700831/full
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Controlled Release and Delivery Laboratory

Full metadata record

DC FieldValue Language
dc.contributor.authorCroissant, Jonas G.en
dc.contributor.authorFatieiev, Yevhenen
dc.contributor.authorAlmalik, Abdulazizen
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2018-01-01T12:19:00Z-
dc.date.available2018-01-01T12:19:00Z-
dc.date.issued2017-11-30en
dc.identifier.citationCroissant JG, Fatieiev Y, Almalik A, Khashab NM (2017) Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications. Advanced Healthcare Materials: 1700831. Available: http://dx.doi.org/10.1002/adhm.201700831.en
dc.identifier.issn2192-2640en
dc.identifier.pmid29193848-
dc.identifier.doi10.1002/adhm.201700831en
dc.identifier.urihttp://hdl.handle.net/10754/626577-
dc.description.abstractPredetermining the physico-chemical properties, biosafety, and stimuli-responsiveness of nanomaterials in biological environments is essential for safe and effective biomedical applications. At the forefront of biomedical research, mesoporous silica nanoparticles and mesoporous organosilica nanoparticles are increasingly investigated to predict their biological outcome by materials design. In this review, it is first chronicled that how the nanomaterial design of pure silica, partially hybridized organosilica, and fully hybridized organosilica (periodic mesoporous organosilicas) governs not only the physico-chemical properties but also the biosafety of the nanoparticles. The impact of the hybridization on the biocompatibility, protein corona, biodistribution, biodegradability, and clearance of the silica-based particles is described. Then, the influence of the surface engineering, the framework hybridization, as well as the morphology of the particles, on the ability to load and controllably deliver drugs under internal biological stimuli (e.g., pH, redox, enzymes) and external noninvasive stimuli (e.g., light, magnetic, ultrasound) are presented. To conclude, trends in the biomedical applications of silica and organosilica nanovectors are delineated, such as unconventional bioimaging techniques, large cargo delivery, combination therapy, gaseous molecule delivery, antimicrobial protection, and Alzheimer's disease therapy.en
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/adhm.201700831/fullen
dc.titleMesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applicationsen
dc.typeArticleen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.identifier.journalAdvanced Healthcare Materialsen
dc.contributor.institutionCenter for Micro-Engineered Materials; Advanced Materials Laboratory; University of New Mexico; MSC04 2790, 1001 University Blvd SE Suite 103 Albuquerque NM 87106 USAen
dc.contributor.institutionChemical and Biological Engineering; University of New Mexico; 210 University Blvd NE Albuquerque NM 87131-0001 USAen
dc.contributor.institutionLife sciences and Environment Research Institute; Center of Excellence in Nanomedicine (CENM); King Abdulaziz City for Science and Technology (KACST); Riyadh 11461 Saudi Arabiaen
kaust.authorFatieiev, Yevhenen
kaust.authorKhashab, Niveen M.en
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