Evolution and Strain Variation in BCG

Handle URI:
http://hdl.handle.net/10754/626272
Title:
Evolution and Strain Variation in BCG
Authors:
Abdallah, Abdallah; Behr, Marcel A.
Abstract:
BCG vaccines were derived by in vitro passage, during the years 1908–1921, at the Pasteur Institute of Lille. Following the distribution of stocks of BCG to vaccine production laboratories around the world, it was only a few decades before different BCG producers recognized that there were variants of BCG, likely due to different passaging conditions in the different laboratories. This ultimately led to the lyophilization of stable BCG products in the 1950s and 1960s, but not before considerable evolution of the different BCG strains had taken place. The application of contemporary research methodologies has now revealed genomic, transcriptomic and proteomic differences between BCG strains. These molecular differences in part account for phenotypic differences in vitro between BCG strains, such as their variable secretion of antigenic proteins. Yet, the relevance of BCG variability for immunization policy remains elusive. In this chapter we present an overview of what is known about BCG evolution and its resulting strain variability, and provide some speculation as to the potential relevance for a vaccine given to over 100 million newborns each year.
KAUST Department:
Bioscience Core Lab
Citation:
Abdallah AM, Behr MA (2017) Evolution and Strain Variation in BCG. Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control: 155–169. Available: http://dx.doi.org/10.1007/978-3-319-64371-7_8.
Publisher:
Springer International Publishing
Journal:
Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control
Issue Date:
7-Nov-2017
DOI:
10.1007/978-3-319-64371-7_8
Type:
Book Chapter
ISSN:
0065-2598; 2214-8019
Additional Links:
https://link.springer.com/chapter/10.1007%2F978-3-319-64371-7_8
Appears in Collections:
Book Chapters; Bioscience Core Lab

Full metadata record

DC FieldValue Language
dc.contributor.authorAbdallah, Abdallahen
dc.contributor.authorBehr, Marcel A.en
dc.date.accessioned2017-12-04T11:40:28Z-
dc.date.available2017-12-04T11:40:28Z-
dc.date.issued2017-11-07en
dc.identifier.citationAbdallah AM, Behr MA (2017) Evolution and Strain Variation in BCG. Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control: 155–169. Available: http://dx.doi.org/10.1007/978-3-319-64371-7_8.en
dc.identifier.issn0065-2598en
dc.identifier.issn2214-8019en
dc.identifier.doi10.1007/978-3-319-64371-7_8en
dc.identifier.urihttp://hdl.handle.net/10754/626272-
dc.description.abstractBCG vaccines were derived by in vitro passage, during the years 1908–1921, at the Pasteur Institute of Lille. Following the distribution of stocks of BCG to vaccine production laboratories around the world, it was only a few decades before different BCG producers recognized that there were variants of BCG, likely due to different passaging conditions in the different laboratories. This ultimately led to the lyophilization of stable BCG products in the 1950s and 1960s, but not before considerable evolution of the different BCG strains had taken place. The application of contemporary research methodologies has now revealed genomic, transcriptomic and proteomic differences between BCG strains. These molecular differences in part account for phenotypic differences in vitro between BCG strains, such as their variable secretion of antigenic proteins. Yet, the relevance of BCG variability for immunization policy remains elusive. In this chapter we present an overview of what is known about BCG evolution and its resulting strain variability, and provide some speculation as to the potential relevance for a vaccine given to over 100 million newborns each year.en
dc.publisherSpringer International Publishingen
dc.relation.urlhttps://link.springer.com/chapter/10.1007%2F978-3-319-64371-7_8en
dc.rightsThe final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-64371-7_8en
dc.subjectTuberculosisen
dc.subjectBCGen
dc.subjectVaccineen
dc.subjectProtectionen
dc.subjectStrainen
dc.titleEvolution and Strain Variation in BCGen
dc.typeBook Chapteren
dc.contributor.departmentBioscience Core Laben
dc.identifier.journalStrain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Controlen
dc.eprint.versionPost-printen
dc.contributor.institutionDepartment of Medicine, McGill University Health Centre, Montreal, Canadaen
kaust.authorAbdallah, Abdallahen
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