Neurobiology of pair bonding in fishes; convergence of neural mechanisms across distant vertebrate lineages

Handle URI:
http://hdl.handle.net/10754/626163
Title:
Neurobiology of pair bonding in fishes; convergence of neural mechanisms across distant vertebrate lineages
Authors:
Nowicki, Jessica ( 0000-0002-6373-8761 ) ; Pratchett, Morgan; Walker, Stefan; Coker, Darren James; O'Connell, Lauren A.
Abstract:
Pair bonding has independently evolved numerous times among vertebrates. The governing neural mechanisms of pair bonding have only been studied in depth in the mammalian model species, the prairie vole, Microtus ochrogaster. In this species, oxytocin (OT), arginine vasopressin (AVP), dopamine (DA), and opioid (OP) systems play key roles in signaling in the formation and maintenance of pair bonding by targeting specific social and reward-mediating brain regions. By contrast, the neural basis of pair bonding is poorly studied in other vertebrates, and especially those of early origins, limiting our understanding of the evolutionary history of pair bonding regulatory mechanisms. We compared receptor gene expression between pair bonded and solitary individuals across eight socio-functional brain regions. We found that in females, ITR and V1aR receptor expression varied in the lateral septum-like region (the Vv/Vl), while in both sexes D1R, D2R, and MOR expression varied within the mesolimbic reward system, including a striatum-like region (the Vc); mirroring sites of action in M. ochrogaster. This study provides novel insights into the neurobiology of teleost pair bonding. It also reveals high convergence in the neurochemical mechanisms governing pair bonding across actinopterygians and sarcopterygians, by repeatedly co-opting and similarly assembling deep neurochemical and neuroanatomical homologies that originated in ancestral osteithes.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Red Sea Research Center (RSRC)
Citation:
Nowicki J, Pratchett M, Walker S, Coker D, O’Connell LA (2017) Neurobiology of pair bonding in fishes; convergence of neural mechanisms across distant vertebrate lineages. Available: http://dx.doi.org/10.1101/214759.
Publisher:
Cold Spring Harbor Laboratory
Issue Date:
14-Nov-2017
DOI:
10.1101/214759
Type:
Preprint
Additional Links:
https://www.biorxiv.org/content/early/2017/11/06/214759
Appears in Collections:
Red Sea Research Center (RSRC); Other/General Submission; Biological and Environmental Sciences and Engineering (BESE) Division; Reef Genomics, part of the Global Ocean Genome Project

Full metadata record

DC FieldValue Language
dc.contributor.authorNowicki, Jessicaen
dc.contributor.authorPratchett, Morganen
dc.contributor.authorWalker, Stefanen
dc.contributor.authorCoker, Darren Jamesen
dc.contributor.authorO'Connell, Lauren A.en
dc.date.accessioned2017-11-15T10:58:19Z-
dc.date.available2017-11-15T10:58:19Z-
dc.date.issued2017-11-14en
dc.identifier.citationNowicki J, Pratchett M, Walker S, Coker D, O’Connell LA (2017) Neurobiology of pair bonding in fishes; convergence of neural mechanisms across distant vertebrate lineages. Available: http://dx.doi.org/10.1101/214759.en
dc.identifier.doi10.1101/214759en
dc.identifier.urihttp://hdl.handle.net/10754/626163-
dc.description.abstractPair bonding has independently evolved numerous times among vertebrates. The governing neural mechanisms of pair bonding have only been studied in depth in the mammalian model species, the prairie vole, Microtus ochrogaster. In this species, oxytocin (OT), arginine vasopressin (AVP), dopamine (DA), and opioid (OP) systems play key roles in signaling in the formation and maintenance of pair bonding by targeting specific social and reward-mediating brain regions. By contrast, the neural basis of pair bonding is poorly studied in other vertebrates, and especially those of early origins, limiting our understanding of the evolutionary history of pair bonding regulatory mechanisms. We compared receptor gene expression between pair bonded and solitary individuals across eight socio-functional brain regions. We found that in females, ITR and V1aR receptor expression varied in the lateral septum-like region (the Vv/Vl), while in both sexes D1R, D2R, and MOR expression varied within the mesolimbic reward system, including a striatum-like region (the Vc); mirroring sites of action in M. ochrogaster. This study provides novel insights into the neurobiology of teleost pair bonding. It also reveals high convergence in the neurochemical mechanisms governing pair bonding across actinopterygians and sarcopterygians, by repeatedly co-opting and similarly assembling deep neurochemical and neuroanatomical homologies that originated in ancestral osteithes.en
dc.publisherCold Spring Harbor Laboratoryen
dc.relation.urlhttps://www.biorxiv.org/content/early/2017/11/06/214759en
dc.rightsThe copyright holder for this preprint is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.titleNeurobiology of pair bonding in fishes; convergence of neural mechanisms across distant vertebrate lineagesen
dc.typePreprinten
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentRed Sea Research Center (RSRC)en
dc.eprint.versionPre-printen
dc.contributor.institutionBiology Department, Stanford University, Stanford, CA 94305en
dc.contributor.institutionARC Centre of Excellence for Coral Reef Studies, James Cook University, Townsville, QLD 4810, Australiaen
dc.contributor.institutionFAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USAen
kaust.authorCoker, Darren Jamesen
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