The Emerging Facets of Non-Cancerous Warburg Effect

Handle URI:
http://hdl.handle.net/10754/626124
Title:
The Emerging Facets of Non-Cancerous Warburg Effect
Authors:
Abdel-Haleem, Alyaa M.; Lewis, Nathan E.; Jamshidi, Neema; Mineta, Katsuhiko ( 0000-0002-4727-045X ) ; Gao, Xin ( 0000-0002-7108-3574 ) ; Gojobori, Takashi ( 0000-0001-7850-1743 )
Abstract:
The Warburg effect (WE), or aerobic glycolysis, is commonly recognized as a hallmark of cancer and has been extensively studied for potential anti-cancer therapeutics development. Beyond cancer, the WE plays an important role in many other cell types involved in immunity, angiogenesis, pluripotency, and infection by pathogens (e.g., malaria). Here, we review the WE in non-cancerous context as a
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Citation:
Abdel-Haleem AM, Lewis NE, Jamshidi N, Mineta K, Gao X, et al. (2017) The Emerging Facets of Non-Cancerous Warburg Effect. Frontiers in Endocrinology 8. Available: http://dx.doi.org/10.3389/fendo.2017.00279.
Publisher:
Frontiers Media SA
Journal:
Frontiers in Endocrinology
KAUST Grant Number:
URF/1/1976-03
Issue Date:
23-Oct-2017
DOI:
10.3389/fendo.2017.00279
Type:
Article
ISSN:
1664-2392
Sponsors:
AMA, XG, KM, and TG acknowledge funding from King Abdullah University of Science and Technology (KAUST) and the Office of Sponsored Research (OSR) under Award No. URF/1/1976-03. NL acknowledges generous support from the Novo Nordisk Foundation grant NNF10CC1016517 and NIH (R35-GM119850 and R01 AI090141).
Additional Links:
https://www.frontiersin.org/articles/10.3389/fendo.2017.00279/full
Appears in Collections:
Articles; Computational Bioscience Research Center (CBRC); Biological and Environmental Sciences and Engineering (BESE) Division; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorAbdel-Haleem, Alyaa M.en
dc.contributor.authorLewis, Nathan E.en
dc.contributor.authorJamshidi, Neemaen
dc.contributor.authorMineta, Katsuhikoen
dc.contributor.authorGao, Xinen
dc.contributor.authorGojobori, Takashien
dc.date.accessioned2017-11-06T07:09:05Z-
dc.date.available2017-11-06T07:09:05Z-
dc.date.issued2017-10-23en
dc.identifier.citationAbdel-Haleem AM, Lewis NE, Jamshidi N, Mineta K, Gao X, et al. (2017) The Emerging Facets of Non-Cancerous Warburg Effect. Frontiers in Endocrinology 8. Available: http://dx.doi.org/10.3389/fendo.2017.00279.en
dc.identifier.issn1664-2392en
dc.identifier.doi10.3389/fendo.2017.00279en
dc.identifier.urihttp://hdl.handle.net/10754/626124-
dc.description.abstractThe Warburg effect (WE), or aerobic glycolysis, is commonly recognized as a hallmark of cancer and has been extensively studied for potential anti-cancer therapeutics development. Beyond cancer, the WE plays an important role in many other cell types involved in immunity, angiogenesis, pluripotency, and infection by pathogens (e.g., malaria). Here, we review the WE in non-cancerous context as aen
dc.description.sponsorshipAMA, XG, KM, and TG acknowledge funding from King Abdullah University of Science and Technology (KAUST) and the Office of Sponsored Research (OSR) under Award No. URF/1/1976-03. NL acknowledges generous support from the Novo Nordisk Foundation grant NNF10CC1016517 and NIH (R35-GM119850 and R01 AI090141).en
dc.publisherFrontiers Media SAen
dc.relation.urlhttps://www.frontiersin.org/articles/10.3389/fendo.2017.00279/fullen
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectWarburg effecten
dc.subjectcanceren
dc.subjectimmune cellsen
dc.subjectmalariaen
dc.subjectangiogenesisen
dc.subjectpluripotencyen
dc.subjectrapid proliferationen
dc.subjectconstraint-based metabolic modelingen
dc.titleThe Emerging Facets of Non-Cancerous Warburg Effecten
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.identifier.journalFrontiers in Endocrinologyen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, , United Statesen
dc.contributor.institutionDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, , United Statesen
dc.contributor.institutionNovo Nordisk Foundation Center for Biosustainability, University of California San Diego School of Medicine, La Jolla, CA, , United Statesen
dc.contributor.institutionDepartment of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, , , United Statesen
dc.contributor.institutionInstitute of Engineering in Medicine, University of California, San Diego, La Jolla, CA, , United Statesen
kaust.authorAbdel-Haleem, Alyaa M.en
kaust.authorMineta, Katsuhikoen
kaust.authorGao, Xinen
kaust.authorGojobori, Takashien
kaust.grant.numberURF/1/1976-03en
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