Localized Electrochemiluminescence from Nanoneedle Electrodes for Very-high-density Electrochemical Sensing

Handle URI:
http://hdl.handle.net/10754/626021
Title:
Localized Electrochemiluminescence from Nanoneedle Electrodes for Very-high-density Electrochemical Sensing
Authors:
Zhang, Jingjing; Zhou, Junyu; Tian, Chunxiu; Yang, Shan; Jiang, Dechen; Zhang, Xixiang ( 0000-0002-3478-6414 ) ; Chen, Hong-Yuan
Abstract:
In this paper, localized electrochemiluminescence (ECL) was visualized from nanoneedle electrodes that achieved very-high-density electrochemical sensing. The localized luminescence at the nanometer-sized tip observed was ascribed to enhanced mass transfer of the luminescence probe at the tip than on the planar surface surrounding the tip, which provided higher luminescence at the tip. The size of the luminescence spots was restricted to 15 μm permitting the electrochemical analysis with a density over 4 × 103 spots/mm2. The positive correlation between the luminescence intensity at the tips and the concentration of hydrogen peroxide supported the quantitative ECL analysis using nanoneedle electrodes. The further modification of glucose oxidase at the electrode surface conceptually demonstrated that the concentration of glucose ranging from 0.5 to 5 mM could be quantified using the luminescence at the tips, which could be further applied for the detection of multiple molecules in the complex biosystem. This successful localized ECL offers a specific strategy for the development of very-high-density electrochemical arrays without the complicated chip design.
KAUST Department:
Physical Sciences and Engineering (PSE) Division
Citation:
Zhang J, Zhou J, Tian C, Yang S, Jiang D, et al. (2017) Localized Electrochemiluminescence from Nanoneedle Electrodes for Very-High-Density Electrochemical Sensing. Analytical Chemistry. Available: http://dx.doi.org/10.1021/acs.analchem.7b02363.
Publisher:
American Chemical Society (ACS)
Journal:
Analytical Chemistry
Issue Date:
28-Sep-2017
DOI:
10.1021/acs.analchem.7b02363
Type:
Article
ISSN:
0003-2700; 1520-6882
Sponsors:
This work was supported by National Key Research and Development Program (Grant 2016YFA0201203) and the National Natural Science Foundation of China (Grants 21327902 and 21575060). C.T., S.Y., and X.-X.Z. would like to acknowledge the financial support from King Abdullah University of Science and Technology (KAUST).
Additional Links:
http://pubs.acs.org/doi/abs/10.1021/acs.analchem.7b02363
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorZhang, Jingjingen
dc.contributor.authorZhou, Junyuen
dc.contributor.authorTian, Chunxiuen
dc.contributor.authorYang, Shanen
dc.contributor.authorJiang, Dechenen
dc.contributor.authorZhang, Xixiangen
dc.contributor.authorChen, Hong-Yuanen
dc.date.accessioned2017-10-30T08:39:51Z-
dc.date.available2017-10-30T08:39:51Z-
dc.date.issued2017-09-28en
dc.identifier.citationZhang J, Zhou J, Tian C, Yang S, Jiang D, et al. (2017) Localized Electrochemiluminescence from Nanoneedle Electrodes for Very-High-Density Electrochemical Sensing. Analytical Chemistry. Available: http://dx.doi.org/10.1021/acs.analchem.7b02363.en
dc.identifier.issn0003-2700en
dc.identifier.issn1520-6882en
dc.identifier.doi10.1021/acs.analchem.7b02363en
dc.identifier.urihttp://hdl.handle.net/10754/626021-
dc.description.abstractIn this paper, localized electrochemiluminescence (ECL) was visualized from nanoneedle electrodes that achieved very-high-density electrochemical sensing. The localized luminescence at the nanometer-sized tip observed was ascribed to enhanced mass transfer of the luminescence probe at the tip than on the planar surface surrounding the tip, which provided higher luminescence at the tip. The size of the luminescence spots was restricted to 15 μm permitting the electrochemical analysis with a density over 4 × 103 spots/mm2. The positive correlation between the luminescence intensity at the tips and the concentration of hydrogen peroxide supported the quantitative ECL analysis using nanoneedle electrodes. The further modification of glucose oxidase at the electrode surface conceptually demonstrated that the concentration of glucose ranging from 0.5 to 5 mM could be quantified using the luminescence at the tips, which could be further applied for the detection of multiple molecules in the complex biosystem. This successful localized ECL offers a specific strategy for the development of very-high-density electrochemical arrays without the complicated chip design.en
dc.description.sponsorshipThis work was supported by National Key Research and Development Program (Grant 2016YFA0201203) and the National Natural Science Foundation of China (Grants 21327902 and 21575060). C.T., S.Y., and X.-X.Z. would like to acknowledge the financial support from King Abdullah University of Science and Technology (KAUST).en
dc.publisherAmerican Chemical Society (ACS)en
dc.relation.urlhttp://pubs.acs.org/doi/abs/10.1021/acs.analchem.7b02363en
dc.titleLocalized Electrochemiluminescence from Nanoneedle Electrodes for Very-high-density Electrochemical Sensingen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalAnalytical Chemistryen
dc.contributor.institutionState Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering Nanjing University, Nanjing, Jiangsu 210093, Chinaen
kaust.authorTian, Chunxiuen
kaust.authorYang, Shanen
kaust.authorZhang, Xixiangen
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