Tunable and Linker Free Nanogaps in Core-Shell Plasmonic Nanorods for Selective and Quantitative Detection of Circulating Tumor Cells by SERS

Handle URI:
http://hdl.handle.net/10754/625911
Title:
Tunable and Linker Free Nanogaps in Core-Shell Plasmonic Nanorods for Selective and Quantitative Detection of Circulating Tumor Cells by SERS
Authors:
Zhang, Yang; Yang, Peng; Madathumpady Abubaker, Habeeb Muhammed; Alsaiari, Shahad K.; Moosa, Basem ( 0000-0002-2350-4100 ) ; AlMalik, Abdulaziz; Kumar, Anjli; Ringe, Emilie; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
Controlling the size, number, and shape of nanogaps in plasmonic nanostructures is of significant importance for the development of novel quantum plasmonic devices and quantitative sensing techniques such as surface-enhanced Raman scattering (SERS). Here, we introduce a new synthetic method based on coordination interactions and galvanic replacement to prepare core-shell plasmonic nanorods with tunable enclosed nanogaps. Decorating Au nanorods with Raman reporters that strongly coordinate Ag+ ions (e.g., 4-mercaptopyridine) afforded uniform nucleation sites to form a sacrificial Ag shell. Galvanic replacement of the Ag shell by HAuCl4 resulted in Au-AgAu core-shell structure with a uniform intra-nanoparticle gap. The size (length and width) and morphology of the core-shell plasmonic nanorods as well as the nanogap size depends on the concentration of the coordination complexes formed between Ag+ ions and 4-mercaptopyridine. Moreover, encapsulating Raman reporters within the nanogaps afforded an internal standard for sensitive and quantitative SERS analysis. To test the applicability, core-shell plasmonic nanorods were functionalized with aptamers specific to circulating tumor cells such as MCF-7 (Michigan Cancer Foundation-7, breast cancer cell line). This system could selectively detect as low as 20 MCF-7 cells in a blood mimicking fluid employing SERS. The linking DNA duplex on core-shell plasmonic nanorods can also intercalate hydrophobic drug molecules such as Doxorubicin, thereby increasing the versatility of this sensing platform to include drug delivery. Our synthetic method offers the possibility of developing multifunctional SERS-active materials with a wide range of applications including bio sensing, imaging and therapy.
KAUST Department:
Advanced Membranes and Porous Materials Research Center; Smart Hybrid Materials (SHMs) lab
Citation:
Zhang Y, Yang P, Habeeb Muhammed MA, Alsaiari SK, Moosa B, et al. (2017) Tunable and Linker Free Nanogaps in Core–Shell Plasmonic Nanorods for Selective and Quantitative Detection of Circulating Tumor Cells by SERS. ACS Applied Materials & Interfaces. Available: http://dx.doi.org/10.1021/acsami.7b10959.
Publisher:
American Chemical Society (ACS)
Journal:
ACS Applied Materials & Interfaces
Issue Date:
9-Oct-2017
DOI:
10.1021/acsami.7b10959
Type:
Article
ISSN:
1944-8244; 1944-8252
Additional Links:
http://pubs.acs.org/doi/abs/10.1021/acsami.7b10959
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Controlled Release and Delivery Laboratory

Full metadata record

DC FieldValue Language
dc.contributor.authorZhang, Yangen
dc.contributor.authorYang, Pengen
dc.contributor.authorMadathumpady Abubaker, Habeeb Muhammeden
dc.contributor.authorAlsaiari, Shahad K.en
dc.contributor.authorMoosa, Basemen
dc.contributor.authorAlMalik, Abdulazizen
dc.contributor.authorKumar, Anjlien
dc.contributor.authorRinge, Emilieen
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2017-10-19T07:10:41Z-
dc.date.available2017-10-19T07:10:41Z-
dc.date.issued2017-10-09en
dc.identifier.citationZhang Y, Yang P, Habeeb Muhammed MA, Alsaiari SK, Moosa B, et al. (2017) Tunable and Linker Free Nanogaps in Core–Shell Plasmonic Nanorods for Selective and Quantitative Detection of Circulating Tumor Cells by SERS. ACS Applied Materials & Interfaces. Available: http://dx.doi.org/10.1021/acsami.7b10959.en
dc.identifier.issn1944-8244en
dc.identifier.issn1944-8252en
dc.identifier.doi10.1021/acsami.7b10959en
dc.identifier.urihttp://hdl.handle.net/10754/625911-
dc.description.abstractControlling the size, number, and shape of nanogaps in plasmonic nanostructures is of significant importance for the development of novel quantum plasmonic devices and quantitative sensing techniques such as surface-enhanced Raman scattering (SERS). Here, we introduce a new synthetic method based on coordination interactions and galvanic replacement to prepare core-shell plasmonic nanorods with tunable enclosed nanogaps. Decorating Au nanorods with Raman reporters that strongly coordinate Ag+ ions (e.g., 4-mercaptopyridine) afforded uniform nucleation sites to form a sacrificial Ag shell. Galvanic replacement of the Ag shell by HAuCl4 resulted in Au-AgAu core-shell structure with a uniform intra-nanoparticle gap. The size (length and width) and morphology of the core-shell plasmonic nanorods as well as the nanogap size depends on the concentration of the coordination complexes formed between Ag+ ions and 4-mercaptopyridine. Moreover, encapsulating Raman reporters within the nanogaps afforded an internal standard for sensitive and quantitative SERS analysis. To test the applicability, core-shell plasmonic nanorods were functionalized with aptamers specific to circulating tumor cells such as MCF-7 (Michigan Cancer Foundation-7, breast cancer cell line). This system could selectively detect as low as 20 MCF-7 cells in a blood mimicking fluid employing SERS. The linking DNA duplex on core-shell plasmonic nanorods can also intercalate hydrophobic drug molecules such as Doxorubicin, thereby increasing the versatility of this sensing platform to include drug delivery. Our synthetic method offers the possibility of developing multifunctional SERS-active materials with a wide range of applications including bio sensing, imaging and therapy.en
dc.publisherAmerican Chemical Society (ACS)en
dc.relation.urlhttp://pubs.acs.org/doi/abs/10.1021/acsami.7b10959en
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acsami.7b10959.en
dc.titleTunable and Linker Free Nanogaps in Core-Shell Plasmonic Nanorods for Selective and Quantitative Detection of Circulating Tumor Cells by SERSen
dc.typeArticleen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.identifier.journalACS Applied Materials & Interfacesen
dc.eprint.versionPost-printen
dc.contributor.institutionLife sciences and Environment Research Institute, Center of Excellence in Nanomedicine (CENM), King Abdulaziz City for Science and Technology (KACST), Riyadh 11461, Saudi Arabiaen
dc.contributor.institutionDepartment of Chemistry, Rice University, Houston TX 77005, USAen
dc.contributor.institutionDepartment of Materials Science and NanoEngineering, Rice University, Houston TX 77005, USAen
kaust.authorZhang, Yangen
kaust.authorYang, Pengen
kaust.authorMadathumpady Abubaker, Habeeb Muhammeden
kaust.authorAlsaiari, Shahad K.en
kaust.authorMoosa, Basemen
kaust.authorKhashab, Niveen M.en
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