Scalable high-affinity stabilization of magnetic iron oxide nanostructures by a biocompatible antifouling homopolymer

Handle URI:
http://hdl.handle.net/10754/625909
Title:
Scalable high-affinity stabilization of magnetic iron oxide nanostructures by a biocompatible antifouling homopolymer
Authors:
Luongo, Giovanni; Campagnolo, Paola; Perez, Jose E. ( 0000-0002-2206-0034 ) ; Kosel, Jürgen ( 0000-0002-8998-8275 ) ; Georgiou, Theoni K.; Regoutz, Anna; Payne, David J; Stevens, Molly M.; Ryan, Mary P.; Porter, Alexandra E; Dunlop, Iain E
Abstract:
Iron oxide nanostructures have been widely developed for biomedical applications, due to their magnetic properties and biocompatibility. In clinical application, the stabilization of these nanostructures against aggregation and non-specific interactions is typically achieved using weakly anchored polysaccharides, with better-defined and more strongly anchored synthetic polymers not commercially adopted due to complexity of synthesis and use. Here, we show for the first time stabilization and biocompatibilization of iron oxide nanoparticles by a synthetic homopolymer with strong surface anchoring and a history of clinical use in other applications, poly(2-methacryloyloxyethy phosphorylcholine) (poly(MPC)). For the commercially important case of spherical particles, binding of poly(MPC) to iron oxide surfaces and highly effective individualization of magnetite nanoparticles (20 nm) are demonstrated. Next-generation high-aspect ratio nanowires (both magnetite/maghemite and core-shell iron/iron oxide) are furthermore stabilized by poly(MPC)-coating, with nanowire cytotoxicity at large concentrations significantly reduced. The synthesis approach is exploited to incorporate functionality into the poly(MPC) chain is demonstrated by random copolymerization with an alkyne-containing monomer for click-chemistry. Taking these results together, poly(MPC) homopolymers and random copolymers offer a significant improvement over current iron oxide nanoformulations, combining straightforward synthesis, strong surface-anchoring and well-defined molecular weight.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division; Electrical Engineering Program
Citation:
Luongo G, Campagnolo P, Perez JE, Kosel J, Georgiou TK, et al. (2017) Scalable high-affinity stabilization of magnetic iron oxide nanostructures by a biocompatible antifouling homopolymer. ACS Applied Materials & Interfaces. Available: http://dx.doi.org/10.1021/acsami.7b12290.
Publisher:
American Chemical Society (ACS)
Journal:
ACS Applied Materials & Interfaces
Issue Date:
12-Oct-2017
DOI:
10.1021/acsami.7b12290
Type:
Article
ISSN:
1944-8244; 1944-8252
Sponsors:
We acknowledge funding from a KAUST Partnership grant (JK, MMS, IED, AEP, GL, PC, JEP).
Additional Links:
http://pubs.acs.org/doi/abs/10.1021/acsami.7b12290
Appears in Collections:
Articles; Bioscience Program; Electrical Engineering Program; Biological and Environmental Sciences and Engineering (BESE) Division; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorLuongo, Giovannien
dc.contributor.authorCampagnolo, Paolaen
dc.contributor.authorPerez, Jose E.en
dc.contributor.authorKosel, Jürgenen
dc.contributor.authorGeorgiou, Theoni K.en
dc.contributor.authorRegoutz, Annaen
dc.contributor.authorPayne, David Jen
dc.contributor.authorStevens, Molly M.en
dc.contributor.authorRyan, Mary P.en
dc.contributor.authorPorter, Alexandra Een
dc.contributor.authorDunlop, Iain Een
dc.date.accessioned2017-10-19T07:10:41Z-
dc.date.available2017-10-19T07:10:41Z-
dc.date.issued2017-10-12en
dc.identifier.citationLuongo G, Campagnolo P, Perez JE, Kosel J, Georgiou TK, et al. (2017) Scalable high-affinity stabilization of magnetic iron oxide nanostructures by a biocompatible antifouling homopolymer. ACS Applied Materials & Interfaces. Available: http://dx.doi.org/10.1021/acsami.7b12290.en
dc.identifier.issn1944-8244en
dc.identifier.issn1944-8252en
dc.identifier.doi10.1021/acsami.7b12290en
dc.identifier.urihttp://hdl.handle.net/10754/625909-
dc.description.abstractIron oxide nanostructures have been widely developed for biomedical applications, due to their magnetic properties and biocompatibility. In clinical application, the stabilization of these nanostructures against aggregation and non-specific interactions is typically achieved using weakly anchored polysaccharides, with better-defined and more strongly anchored synthetic polymers not commercially adopted due to complexity of synthesis and use. Here, we show for the first time stabilization and biocompatibilization of iron oxide nanoparticles by a synthetic homopolymer with strong surface anchoring and a history of clinical use in other applications, poly(2-methacryloyloxyethy phosphorylcholine) (poly(MPC)). For the commercially important case of spherical particles, binding of poly(MPC) to iron oxide surfaces and highly effective individualization of magnetite nanoparticles (20 nm) are demonstrated. Next-generation high-aspect ratio nanowires (both magnetite/maghemite and core-shell iron/iron oxide) are furthermore stabilized by poly(MPC)-coating, with nanowire cytotoxicity at large concentrations significantly reduced. The synthesis approach is exploited to incorporate functionality into the poly(MPC) chain is demonstrated by random copolymerization with an alkyne-containing monomer for click-chemistry. Taking these results together, poly(MPC) homopolymers and random copolymers offer a significant improvement over current iron oxide nanoformulations, combining straightforward synthesis, strong surface-anchoring and well-defined molecular weight.en
dc.description.sponsorshipWe acknowledge funding from a KAUST Partnership grant (JK, MMS, IED, AEP, GL, PC, JEP).en
dc.publisherAmerican Chemical Society (ACS)en
dc.relation.urlhttp://pubs.acs.org/doi/abs/10.1021/acsami.7b12290en
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acsami.7b12290.en
dc.titleScalable high-affinity stabilization of magnetic iron oxide nanostructures by a biocompatible antifouling homopolymeren
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentBioscience Programen
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.contributor.departmentElectrical Engineering Programen
dc.identifier.journalACS Applied Materials & Interfacesen
dc.eprint.versionPost-printen
dc.contributor.institutionDepartment of Materials, Imperial College London, London SW7 2AZ, United Kingdom.en
kaust.authorPerez, Jose E.en
kaust.authorKosel, Jürgenen
kaust.authorPayne, David Jen
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