A preclinical model for identifying rats at risk of alcohol use disorder

Handle URI:
http://hdl.handle.net/10754/625811
Title:
A preclinical model for identifying rats at risk of alcohol use disorder
Authors:
Jadhav, Kshitij S. ( 0000-0001-9795-8335 ) ; Magistretti, Pierre J. ( 0000-0002-6678-320X ) ; Halfon, Olivier; Augsburger, Marc; Boutrel, Benjamin ( 0000-0003-4988-759X )
Abstract:
Alcohol use is one of the world's leading causes of death and disease, although only a small proportion of individuals develop persistent alcohol use disorder (AUD). The identification of vulnerable individuals prior to their chronic intoxication remains of highest importance. We propose here to adapt current methodologies for identifying rats at risk of losing control over alcohol intake by modeling diagnostic criteria for AUD: Inability to abstain during a signaled period of reward unavailability, increased motivation assessed in a progressive effortful task and persistent alcohol intake despite aversive foot shocks. Factor analysis showed that these three addiction criteria loaded on one underlying construct indicating that they represent a latent construct of addiction trait. Further, not only vulnerable rats displayed higher ethanol consumption, and higher preference for ethanol over sweetened solutions, but they also exhibited pre-existing higher anxiety as compared to resilient rats. In conclusion, the present preclinical model confirms that development of an addiction trait not only requires prolonged exposure to alcohol, but also depends on endophenotype like anxiety that predispose a minority of individuals to lose control over alcohol consumption.
KAUST Department:
King Abdullah University of Science and Technology (KAUST), Thuwal, , Saudi Arabia
Citation:
Jadhav KS, Magistretti PJ, Halfon O, Augsburger M, Boutrel B (2017) A preclinical model for identifying rats at risk of alcohol use disorder. Scientific Reports 7. Available: http://dx.doi.org/10.1038/s41598-017-09801-1.
Publisher:
Springer Nature
Journal:
Scientific Reports
Issue Date:
21-Aug-2017
DOI:
10.1038/s41598-017-09801-1
Type:
Article
ISSN:
2045-2322
Sponsors:
The authors thank the technical assistance of Sara Bernasconi, Clarisse Meneghel and Vanessa Pierroz. The financial support of the Division of Child and Adolescent Psychiatry, Department of Psychiatry, Lausanne University Hospital, Switzerland is gratefully acknowledged.
Additional Links:
https://www.nature.com/articles/s41598-017-09801-1
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorJadhav, Kshitij S.en
dc.contributor.authorMagistretti, Pierre J.en
dc.contributor.authorHalfon, Olivieren
dc.contributor.authorAugsburger, Marcen
dc.contributor.authorBoutrel, Benjaminen
dc.date.accessioned2017-10-05T12:47:09Z-
dc.date.available2017-10-05T12:47:09Z-
dc.date.issued2017-08-21en
dc.identifier.citationJadhav KS, Magistretti PJ, Halfon O, Augsburger M, Boutrel B (2017) A preclinical model for identifying rats at risk of alcohol use disorder. Scientific Reports 7. Available: http://dx.doi.org/10.1038/s41598-017-09801-1.en
dc.identifier.issn2045-2322en
dc.identifier.doi10.1038/s41598-017-09801-1en
dc.identifier.urihttp://hdl.handle.net/10754/625811-
dc.description.abstractAlcohol use is one of the world's leading causes of death and disease, although only a small proportion of individuals develop persistent alcohol use disorder (AUD). The identification of vulnerable individuals prior to their chronic intoxication remains of highest importance. We propose here to adapt current methodologies for identifying rats at risk of losing control over alcohol intake by modeling diagnostic criteria for AUD: Inability to abstain during a signaled period of reward unavailability, increased motivation assessed in a progressive effortful task and persistent alcohol intake despite aversive foot shocks. Factor analysis showed that these three addiction criteria loaded on one underlying construct indicating that they represent a latent construct of addiction trait. Further, not only vulnerable rats displayed higher ethanol consumption, and higher preference for ethanol over sweetened solutions, but they also exhibited pre-existing higher anxiety as compared to resilient rats. In conclusion, the present preclinical model confirms that development of an addiction trait not only requires prolonged exposure to alcohol, but also depends on endophenotype like anxiety that predispose a minority of individuals to lose control over alcohol consumption.en
dc.description.sponsorshipThe authors thank the technical assistance of Sara Bernasconi, Clarisse Meneghel and Vanessa Pierroz. The financial support of the Division of Child and Adolescent Psychiatry, Department of Psychiatry, Lausanne University Hospital, Switzerland is gratefully acknowledged.en
dc.publisherSpringer Natureen
dc.relation.urlhttps://www.nature.com/articles/s41598-017-09801-1en
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleA preclinical model for identifying rats at risk of alcohol use disorderen
dc.typeArticleen
dc.contributor.departmentKing Abdullah University of Science and Technology (KAUST), Thuwal, , Saudi Arabiaen
dc.identifier.journalScientific Reportsen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionCenter for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Lausanne, , Switzerlanden
dc.contributor.institutionBrain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, , Switzerlanden
dc.contributor.institutionDivision of Adolescent and Child Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, , Switzerlanden
dc.contributor.institutionToxicology and Forensic Chemistry Unit, University Center of Legal Medicine, Lausanne, Geneva, , Switzerlanden
kaust.authorMagistretti, Pierre J.en
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