Nickel-Catalyzed C–CN Bond Formation via Decarbonylative Cyanation of Esters, Amides, and Intramolecular Recombination Fragment Coupling of Acyl Cyanides

Handle URI:
http://hdl.handle.net/10754/625724
Title:
Nickel-Catalyzed C–CN Bond Formation via Decarbonylative Cyanation of Esters, Amides, and Intramolecular Recombination Fragment Coupling of Acyl Cyanides
Authors:
Chatupheeraphat, Adisak; Liao, Hsuan-Hung; Lee, Shao-Chi; Rueping, Magnus ( 0000-0003-4580-5227 )
Abstract:
An efficient nickel-catalyzed decarbonylative cyanation reaction which allows the direct functional-group interconversion of readily available esters into the corresponding nitriles was developed. This reaction successfully offers access to structurally diverse nitriles with high efficiency and excellent functional-group tolerance and provides a good alternative to classical synthetic pathways from diazonium salts or organic halide compounds.
KAUST Department:
KAUST Catalysis Center (KCC)
Citation:
Chatupheeraphat A, Liao H-H, Lee S-C, Rueping M (2017) Nickel-Catalyzed C–CN Bond Formation via Decarbonylative Cyanation of Esters, Amides, and Intramolecular Recombination Fragment Coupling of Acyl Cyanides. Organic Letters 19: 4255–4258. Available: http://dx.doi.org/10.1021/acs.orglett.7b01905.
Publisher:
American Chemical Society (ACS)
Journal:
Organic Letters
Issue Date:
7-Aug-2017
DOI:
10.1021/acs.orglett.7b01905
Type:
Article
ISSN:
1523-7060; 1523-7052
Additional Links:
http://pubs.acs.org/doi/full/10.1021/acs.orglett.7b01905
Appears in Collections:
Articles; KAUST Catalysis Center (KCC)

Full metadata record

DC FieldValue Language
dc.contributor.authorChatupheeraphat, Adisaken
dc.contributor.authorLiao, Hsuan-Hungen
dc.contributor.authorLee, Shao-Chien
dc.contributor.authorRueping, Magnusen
dc.date.accessioned2017-10-03T12:49:36Z-
dc.date.available2017-10-03T12:49:36Z-
dc.date.issued2017-08-07en
dc.identifier.citationChatupheeraphat A, Liao H-H, Lee S-C, Rueping M (2017) Nickel-Catalyzed C–CN Bond Formation via Decarbonylative Cyanation of Esters, Amides, and Intramolecular Recombination Fragment Coupling of Acyl Cyanides. Organic Letters 19: 4255–4258. Available: http://dx.doi.org/10.1021/acs.orglett.7b01905.en
dc.identifier.issn1523-7060en
dc.identifier.issn1523-7052en
dc.identifier.doi10.1021/acs.orglett.7b01905en
dc.identifier.urihttp://hdl.handle.net/10754/625724-
dc.description.abstractAn efficient nickel-catalyzed decarbonylative cyanation reaction which allows the direct functional-group interconversion of readily available esters into the corresponding nitriles was developed. This reaction successfully offers access to structurally diverse nitriles with high efficiency and excellent functional-group tolerance and provides a good alternative to classical synthetic pathways from diazonium salts or organic halide compounds.en
dc.publisherAmerican Chemical Society (ACS)en
dc.relation.urlhttp://pubs.acs.org/doi/full/10.1021/acs.orglett.7b01905en
dc.titleNickel-Catalyzed C–CN Bond Formation via Decarbonylative Cyanation of Esters, Amides, and Intramolecular Recombination Fragment Coupling of Acyl Cyanidesen
dc.typeArticleen
dc.contributor.departmentKAUST Catalysis Center (KCC)en
dc.identifier.journalOrganic Lettersen
dc.contributor.institutionInstitute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germanyen
kaust.authorRueping, Magnusen
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