Epigenome-associated phenotypic acclimatization to ocean acidification in a reef-building coral

Handle URI:
http://hdl.handle.net/10754/625479
Title:
Epigenome-associated phenotypic acclimatization to ocean acidification in a reef-building coral
Authors:
Liew, Yi Jin ( 0000-0003-2553-8870 ) ; Zoccola, Didier ( 0000-0002-1524-8098 ) ; Li, Yong ( 0000-0003-2609-2401 ) ; Tambutté, Eric; Venn, Alexander A.; Michell, Craig; Cui, Guoxin; Deutekom, Eva S.; Kaandorp, Jaap A.; Voolstra, Christian R. ( 0000-0003-4555-3795 ) ; Forêt, Sylvain; Allemand, Denis; Tambutté, Sylvie; Aranda, Manuel ( 0000-0001-6673-016X )
Abstract:
Over the last century, the anthropogenic production of CO2 has led to warmer (+0.74 C) and more acidic (-0.1 pH) oceans, resulting in increasingly frequent and severe mass bleaching events worldwide that precipitate global coral reef decline. To mitigate this decline, proposals to augment the stress tolerance of corals through genetic and non-genetic means have been gaining traction. Work on model systems has shown that environmentally induced alterations in DNA methylation can lead to phenotypic acclimatization. While DNA methylation has been observed in corals, its potential role in phenotypic plasticity has not yet been described. Here, we show that, similar to findings in mice, DNA methylation significantly reduces spurious transcription in the Red Sea coral Stylophora pistillata, suggesting the evolutionary conservation of this essential mechanism in corals. Furthermore, we find that DNA methylation also reduces transcriptional noise by fine-tuning the expression of highly expressed genes. Analysis of DNA methylation patterns of corals subjected to long-term pH stress showed widespread changes in pathways regulating cell cycle and body size. Correspondingly, we found significant increases in cell and polyp sizes that resulted in more porous skeletons, supporting the maintenance of linear extension rates under conditions of reduced calcification. These findings suggest an epigenetic component in phenotypic acclimatization, providing corals with an additional mechanism to cope with climate change.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Red Sea Research Center (RSRC)
Citation:
Liew YJ, Zoccola D, Li Y, Tambutté E, Venn AA, et al. (2017) Epigenome-associated phenotypic acclimatization to ocean acidification in a reef-building coral. Available: http://dx.doi.org/10.1101/188227.
Publisher:
Cold Spring Harbor Laboratory
Issue Date:
14-Sep-2017
DOI:
10.1101/188227
Type:
Working Paper
Sponsors:
We thank Dominique Desgre, Natacha Caminiti-Segonds and Nathalie Techer for assistance in coral husbandry; the KAUST Sequencing Core Facility for the sequencing of the libraries; Nathalie Techer for cell size measurements; and Pierre Alemanno and Christophe Sattonnet (Polyclinique St Jean, Cagnes sur Mer, France) for access to the micro-CT. This publication is based upon work supported by the King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research (OSR) under Award No. FCC/1/1973-22-01.
Additional Links:
http://www.biorxiv.org/content/early/2017/09/13/188227
Appears in Collections:
Red Sea Research Center (RSRC); Other/General Submission; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorLiew, Yi Jinen
dc.contributor.authorZoccola, Didieren
dc.contributor.authorLi, Yongen
dc.contributor.authorTambutté, Ericen
dc.contributor.authorVenn, Alexander A.en
dc.contributor.authorMichell, Craigen
dc.contributor.authorCui, Guoxinen
dc.contributor.authorDeutekom, Eva S.en
dc.contributor.authorKaandorp, Jaap A.en
dc.contributor.authorVoolstra, Christian R.en
dc.contributor.authorForêt, Sylvainen
dc.contributor.authorAllemand, Denisen
dc.contributor.authorTambutté, Sylvieen
dc.contributor.authorAranda, Manuelen
dc.date.accessioned2017-09-20T06:02:14Z-
dc.date.available2017-09-20T06:02:14Z-
dc.date.issued2017-09-14en
dc.identifier.citationLiew YJ, Zoccola D, Li Y, Tambutté E, Venn AA, et al. (2017) Epigenome-associated phenotypic acclimatization to ocean acidification in a reef-building coral. Available: http://dx.doi.org/10.1101/188227.en
dc.identifier.doi10.1101/188227en
dc.identifier.urihttp://hdl.handle.net/10754/625479-
dc.description.abstractOver the last century, the anthropogenic production of CO2 has led to warmer (+0.74 C) and more acidic (-0.1 pH) oceans, resulting in increasingly frequent and severe mass bleaching events worldwide that precipitate global coral reef decline. To mitigate this decline, proposals to augment the stress tolerance of corals through genetic and non-genetic means have been gaining traction. Work on model systems has shown that environmentally induced alterations in DNA methylation can lead to phenotypic acclimatization. While DNA methylation has been observed in corals, its potential role in phenotypic plasticity has not yet been described. Here, we show that, similar to findings in mice, DNA methylation significantly reduces spurious transcription in the Red Sea coral Stylophora pistillata, suggesting the evolutionary conservation of this essential mechanism in corals. Furthermore, we find that DNA methylation also reduces transcriptional noise by fine-tuning the expression of highly expressed genes. Analysis of DNA methylation patterns of corals subjected to long-term pH stress showed widespread changes in pathways regulating cell cycle and body size. Correspondingly, we found significant increases in cell and polyp sizes that resulted in more porous skeletons, supporting the maintenance of linear extension rates under conditions of reduced calcification. These findings suggest an epigenetic component in phenotypic acclimatization, providing corals with an additional mechanism to cope with climate change.en
dc.description.sponsorshipWe thank Dominique Desgre, Natacha Caminiti-Segonds and Nathalie Techer for assistance in coral husbandry; the KAUST Sequencing Core Facility for the sequencing of the libraries; Nathalie Techer for cell size measurements; and Pierre Alemanno and Christophe Sattonnet (Polyclinique St Jean, Cagnes sur Mer, France) for access to the micro-CT. This publication is based upon work supported by the King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research (OSR) under Award No. FCC/1/1973-22-01.en
dc.publisherCold Spring Harbor Laboratoryen
dc.relation.urlhttp://www.biorxiv.org/content/early/2017/09/13/188227en
dc.rightsThe copyright holder for this preprint is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectEpigeneticsen
dc.subjectDNA methylationen
dc.subjectcoral reefen
dc.subjectcnidarianen
dc.subjectocean acidificationen
dc.titleEpigenome-associated phenotypic acclimatization to ocean acidification in a reef-building coralen
dc.typeWorking Paperen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentRed Sea Research Center (RSRC)en
dc.eprint.versionPre-printen
dc.contributor.institutionCentre Scientifique de Monaco, Marine Biology Department, Principality of Monaco.en
dc.contributor.institutionComputational Science Lab, Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands.en
dc.contributor.institutionResearch School of Biology, Australian National University, Canberra, Australiaen
kaust.authorLiew, Yi Jinen
kaust.authorLi, Yongen
kaust.authorMichell, Craigen
kaust.authorCui, Guoxinen
kaust.authorVoolstra, Christian R.en
kaust.authorAranda, Manuelen
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