Revealing the Cytotoxicity of Residues of Phosphazene Catalysts Used for Synthesis of Poly(ethylene oxide)

Handle URI:
http://hdl.handle.net/10754/625428
Title:
Revealing the Cytotoxicity of Residues of Phosphazene Catalysts Used for Synthesis of Poly(ethylene oxide)
Authors:
Xia, Yening; Shen, Jizhou; Alamri, Haleema ( 0000-0002-0354-7517 ) ; Hadjichristidis, Nikolaos ( 0000-0003-1442-1714 ) ; Zhao, Junpeng; Wang, Yucai; Zhang, Guangzhao
Abstract:
We herein report a case study on the toxicity of residual catalyst in metal-free polymer. Eight-arm star-like poly(ethylene oxide)s were successfully synthesized via phosphazene-catalyzed ring-opening polymerization of ethylene oxide using sucrose as an octahydroxy initiator. The products were subjected to MTT assay using human cancer cell lines (MDA-MB-231 and A2780). Comparison between the crude and purified products clearly revealed that the residual phosphazenium salts were considerably cytotoxic regardless of the anionic species, and that the cytotoxicity of more bulky t-BuP4 salt was higher than that of t-BuP2 salt. Such results have therefore put forward the necessity for removal of the catalyst residues from PEO-based polymers synthesized through phosphazene catalysis for bio-related applications, and for the development of less or non-toxic organocatalysts for such polymers.
KAUST Department:
KAUST Catalysis Center (KCC); Physical Sciences and Engineering (PSE) Division; Polymer Synthesis Laboratory
Citation:
Xia Y, Shen J, Alamri H, Hadjichristidis N, Zhao J, et al. (2017) Revealing the Cytotoxicity of Residues of Phosphazene Catalysts Used for Synthesis of Poly(ethylene oxide). Biomacromolecules. Available: http://dx.doi.org/10.1021/acs.biomac.7b00891.
Publisher:
American Chemical Society (ACS)
Journal:
Biomacromolecules
Issue Date:
24-Aug-2017
DOI:
10.1021/acs.biomac.7b00891
Type:
Article
ISSN:
1525-7797; 1526-4602
Sponsors:
J. Zhao thanks the financial supports of National Natural Science Foundation of China (21674038, 21504024) and Fundamental Research Funds for Central Universities (2017ZD072). Y. Wang thanks the financial support of National Natural Science Foundation of China (51573176). H. Alamri and N. Hadjichristidis thank King Abdullah University of Science and Technology (KAUST) for financial support.
Additional Links:
http://pubs.acs.org/doi/abs/10.1021/acs.biomac.7b00891
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division; KAUST Catalysis Center (KCC)

Full metadata record

DC FieldValue Language
dc.contributor.authorXia, Yeningen
dc.contributor.authorShen, Jizhouen
dc.contributor.authorAlamri, Haleemaen
dc.contributor.authorHadjichristidis, Nikolaosen
dc.contributor.authorZhao, Junpengen
dc.contributor.authorWang, Yucaien
dc.contributor.authorZhang, Guangzhaoen
dc.date.accessioned2017-08-30T11:40:26Z-
dc.date.available2017-08-30T11:40:26Z-
dc.date.issued2017-08-24en
dc.identifier.citationXia Y, Shen J, Alamri H, Hadjichristidis N, Zhao J, et al. (2017) Revealing the Cytotoxicity of Residues of Phosphazene Catalysts Used for Synthesis of Poly(ethylene oxide). Biomacromolecules. Available: http://dx.doi.org/10.1021/acs.biomac.7b00891.en
dc.identifier.issn1525-7797en
dc.identifier.issn1526-4602en
dc.identifier.doi10.1021/acs.biomac.7b00891en
dc.identifier.urihttp://hdl.handle.net/10754/625428-
dc.description.abstractWe herein report a case study on the toxicity of residual catalyst in metal-free polymer. Eight-arm star-like poly(ethylene oxide)s were successfully synthesized via phosphazene-catalyzed ring-opening polymerization of ethylene oxide using sucrose as an octahydroxy initiator. The products were subjected to MTT assay using human cancer cell lines (MDA-MB-231 and A2780). Comparison between the crude and purified products clearly revealed that the residual phosphazenium salts were considerably cytotoxic regardless of the anionic species, and that the cytotoxicity of more bulky t-BuP4 salt was higher than that of t-BuP2 salt. Such results have therefore put forward the necessity for removal of the catalyst residues from PEO-based polymers synthesized through phosphazene catalysis for bio-related applications, and for the development of less or non-toxic organocatalysts for such polymers.en
dc.description.sponsorshipJ. Zhao thanks the financial supports of National Natural Science Foundation of China (21674038, 21504024) and Fundamental Research Funds for Central Universities (2017ZD072). Y. Wang thanks the financial support of National Natural Science Foundation of China (51573176). H. Alamri and N. Hadjichristidis thank King Abdullah University of Science and Technology (KAUST) for financial support.en
dc.publisherAmerican Chemical Society (ACS)en
dc.relation.urlhttp://pubs.acs.org/doi/abs/10.1021/acs.biomac.7b00891en
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Biomacromolecules, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acs.biomac.7b00891.en
dc.titleRevealing the Cytotoxicity of Residues of Phosphazene Catalysts Used for Synthesis of Poly(ethylene oxide)en
dc.typeArticleen
dc.contributor.departmentKAUST Catalysis Center (KCC)en
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentPolymer Synthesis Laboratoryen
dc.identifier.journalBiomacromoleculesen
dc.eprint.versionPost-printen
dc.contributor.institutionFaculty of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, P. R. Chinaen
dc.contributor.institutionSchool of Life Sciences, University of Science and Technology of China, Hefei 230027, P. R. Chinaen
kaust.authorAlamri, Haleemaen
kaust.authorHadjichristidis, Nikolaosen
All Items in KAUST are protected by copyright, with all rights reserved, unless otherwise indicated.