Covalent Organic Framework Material bearing Phloroglucinol Building Units as a Potent Anticancer Agent

Handle URI:
http://hdl.handle.net/10754/625421
Title:
Covalent Organic Framework Material bearing Phloroglucinol Building Units as a Potent Anticancer Agent
Authors:
Bhanja, Piyali; Mishra, Snehasis; Manna, Krishnendu; Mallick, Arijit; Das Saha, Krishna; Bhaumik, Asim
Abstract:
Covalent organic frameworks (COFs) having periodicity in pores of nanoscale dimensions can be suitably designed for the organic building units bearing reactive functional groups at their surfaces. Thus, they are an attractive option as an anticancer agent to overcome the limitations of chemotherapy. Herein, we first report a new porous biodegradable nitrogen containing COF material, EDTFP-1 (ethylenedianiline-triformyl phloroglucinol), synthesized using 4,4'-ethylenedianiline and 2,4,6-triformylphloroglucinol via Schiff base condensation reaction. EDTFP-1 exhibited 3D-hexagonal porous structure with average pores of ca. 1.5 nm dimension. Here, we have explored the anti-cancer potentiality of EDTFP-1. Result demonstrated an enhanced cytotoxicity was observed against four cancer cells HCT 116, HepG2, A549, and MIA-Paca2 with significant lower IC50 on HCT116 cells. Additionally, EDTFP-1-induced cell death was associated with the characteristic apoptotic changes like cell membrane blebbing, nuclear DNA fragmentation, externalization of phosphatidylserine from the cell membrane followed by a loss of mitochondrial membrane potential as well as modulation of pro and anti-apoptotic proteins. Further, the result depicted a direct correlation between the generations of ROS with mitochondrial-dependant apoptosis through the involvement of p53 phosphorylation upon EDTFP-1 induction, suggesting this COF material is a novel chemotherapeutic agent for cancer treatment.
KAUST Department:
Advanced Membranes and Porous Materials Research Center; Physical Sciences and Engineering (PSE) Division
Citation:
Bhanja P, Mishra S, Manna K, Mallick A, Das Saha K, et al. (2017) Covalent Organic Framework Material bearing Phloroglucinol Building Units as a Potent Anticancer Agent. ACS Applied Materials & Interfaces. Available: http://dx.doi.org/10.1021/acsami.7b07343.
Publisher:
American Chemical Society (ACS)
Journal:
ACS Applied Materials & Interfaces
Issue Date:
23-Aug-2017
DOI:
10.1021/acsami.7b07343
Type:
Article
ISSN:
1944-8244; 1944-8252
Sponsors:
PB thanks to CSIR, New Delhi for a senior research fellowship. AB wishes to thank DST, New Delhi for instrumental facilities through DST Unit on Nanoscience.
Additional Links:
http://pubs.acs.org/doi/abs/10.1021/acsami.7b07343
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Physical Sciences and Engineering (PSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorBhanja, Piyalien
dc.contributor.authorMishra, Snehasisen
dc.contributor.authorManna, Krishnenduen
dc.contributor.authorMallick, Arijiten
dc.contributor.authorDas Saha, Krishnaen
dc.contributor.authorBhaumik, Asimen
dc.date.accessioned2017-08-30T11:40:25Z-
dc.date.available2017-08-30T11:40:25Z-
dc.date.issued2017-08-23en
dc.identifier.citationBhanja P, Mishra S, Manna K, Mallick A, Das Saha K, et al. (2017) Covalent Organic Framework Material bearing Phloroglucinol Building Units as a Potent Anticancer Agent. ACS Applied Materials & Interfaces. Available: http://dx.doi.org/10.1021/acsami.7b07343.en
dc.identifier.issn1944-8244en
dc.identifier.issn1944-8252en
dc.identifier.doi10.1021/acsami.7b07343en
dc.identifier.urihttp://hdl.handle.net/10754/625421-
dc.description.abstractCovalent organic frameworks (COFs) having periodicity in pores of nanoscale dimensions can be suitably designed for the organic building units bearing reactive functional groups at their surfaces. Thus, they are an attractive option as an anticancer agent to overcome the limitations of chemotherapy. Herein, we first report a new porous biodegradable nitrogen containing COF material, EDTFP-1 (ethylenedianiline-triformyl phloroglucinol), synthesized using 4,4'-ethylenedianiline and 2,4,6-triformylphloroglucinol via Schiff base condensation reaction. EDTFP-1 exhibited 3D-hexagonal porous structure with average pores of ca. 1.5 nm dimension. Here, we have explored the anti-cancer potentiality of EDTFP-1. Result demonstrated an enhanced cytotoxicity was observed against four cancer cells HCT 116, HepG2, A549, and MIA-Paca2 with significant lower IC50 on HCT116 cells. Additionally, EDTFP-1-induced cell death was associated with the characteristic apoptotic changes like cell membrane blebbing, nuclear DNA fragmentation, externalization of phosphatidylserine from the cell membrane followed by a loss of mitochondrial membrane potential as well as modulation of pro and anti-apoptotic proteins. Further, the result depicted a direct correlation between the generations of ROS with mitochondrial-dependant apoptosis through the involvement of p53 phosphorylation upon EDTFP-1 induction, suggesting this COF material is a novel chemotherapeutic agent for cancer treatment.en
dc.description.sponsorshipPB thanks to CSIR, New Delhi for a senior research fellowship. AB wishes to thank DST, New Delhi for instrumental facilities through DST Unit on Nanoscience.en
dc.publisherAmerican Chemical Society (ACS)en
dc.relation.urlhttp://pubs.acs.org/doi/abs/10.1021/acsami.7b07343en
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acsami.7b07343.en
dc.titleCovalent Organic Framework Material bearing Phloroglucinol Building Units as a Potent Anticancer Agenten
dc.typeArticleen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalACS Applied Materials & Interfacesen
dc.eprint.versionPost-printen
dc.contributor.institutionDepartment of Materials Science, Indian Association for the Cultivation of Science, Jadavpur, Kolkata – 700 032, India.en
dc.contributor.institutionCancer & Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, Kolkata-700032, India.en
kaust.authorMallick, Arijiten
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