An Overview of Lipid Droplets in Cancer and Cancer Stem Cells

Handle URI:
http://hdl.handle.net/10754/625359
Title:
An Overview of Lipid Droplets in Cancer and Cancer Stem Cells
Authors:
Tirinato, Luca ( 0000-0001-9826-2129 ) ; Pagliari, Francesca ( 0000-0002-5547-222X ) ; Limongi, Tania ( 0000-0001-5510-5561 ) ; Marini, Monica ( 0000-0001-8182-5239 ) ; Falqui, Andrea ( 0000-0002-1476-7742 ) ; Seco, J.; Candeloro, P. ( 0000-0001-6156-887X ) ; Liberale, Carlo ( 0000-0002-5653-199X ) ; Di Fabrizio, Enzo M. ( 0000-0001-5886-4678 )
Abstract:
For decades, lipid droplets have been considered as the main cellular organelles involved in the fat storage, because of their lipid composition. However, in recent years, some new and totally unexpected roles have been discovered for them: (i) they are active sites for synthesis and storage of inflammatory mediators, and (ii) they are key players in cancer cells and tissues, especially in cancer stem cells. In this review, we summarize the main concepts related to the lipid droplet structure and function and their involvement in inflammatory and cancer processes.
KAUST Department:
Physical Sciences and Engineering (PSE) Division; Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Tirinato L, Pagliari F, Limongi T, Marini M, Falqui A, et al. (2017) An Overview of Lipid Droplets in Cancer and Cancer Stem Cells. Stem Cells International 2017: 1–17. Available: http://dx.doi.org/10.1155/2017/1656053.
Publisher:
Hindawi Limited
Journal:
Stem Cells International
Issue Date:
13-Aug-2017
DOI:
10.1155/2017/1656053
Type:
Article
ISSN:
1687-966X; 1687-9678
Sponsors:
The authors acknowledge financial support from KAUST Baseline Research Funds (BAS/1-1064-01-01 and BAS/1-1066-01-01) to C. Liberale and A. Falqui, respectively, and from KAUST start-up funding (Project no. GR-2010-2320665) to E. Di Fabrizio.
Additional Links:
https://www.hindawi.com/journals/sci/2017/1656053/
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorTirinato, Lucaen
dc.contributor.authorPagliari, Francescaen
dc.contributor.authorLimongi, Taniaen
dc.contributor.authorMarini, Monicaen
dc.contributor.authorFalqui, Andreaen
dc.contributor.authorSeco, J.en
dc.contributor.authorCandeloro, P.en
dc.contributor.authorLiberale, Carloen
dc.contributor.authorDi Fabrizio, Enzo M.en
dc.date.accessioned2017-08-21T06:28:04Z-
dc.date.available2017-08-21T06:28:04Z-
dc.date.issued2017-08-13en
dc.identifier.citationTirinato L, Pagliari F, Limongi T, Marini M, Falqui A, et al. (2017) An Overview of Lipid Droplets in Cancer and Cancer Stem Cells. Stem Cells International 2017: 1–17. Available: http://dx.doi.org/10.1155/2017/1656053.en
dc.identifier.issn1687-966Xen
dc.identifier.issn1687-9678en
dc.identifier.doi10.1155/2017/1656053en
dc.identifier.urihttp://hdl.handle.net/10754/625359-
dc.description.abstractFor decades, lipid droplets have been considered as the main cellular organelles involved in the fat storage, because of their lipid composition. However, in recent years, some new and totally unexpected roles have been discovered for them: (i) they are active sites for synthesis and storage of inflammatory mediators, and (ii) they are key players in cancer cells and tissues, especially in cancer stem cells. In this review, we summarize the main concepts related to the lipid droplet structure and function and their involvement in inflammatory and cancer processes.en
dc.description.sponsorshipThe authors acknowledge financial support from KAUST Baseline Research Funds (BAS/1-1064-01-01 and BAS/1-1066-01-01) to C. Liberale and A. Falqui, respectively, and from KAUST start-up funding (Project no. GR-2010-2320665) to E. Di Fabrizio.en
dc.publisherHindawi Limiteden
dc.relation.urlhttps://www.hindawi.com/journals/sci/2017/1656053/en
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleAn Overview of Lipid Droplets in Cancer and Cancer Stem Cellsen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalStem Cells Internationalen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionGerman Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, Germanyen
dc.contributor.institutionDepartment of Applied Science and Technology (DISAT), Politecnico di Torino, Torino, Italyen
dc.contributor.institutionBioNEM Lab, Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italyen
kaust.authorTirinato, Lucaen
kaust.authorPagliari, Francescaen
kaust.authorLimongi, Taniaen
kaust.authorMarini, Monicaen
kaust.authorFalqui, Andreaen
kaust.authorLiberale, Carloen
kaust.authorDi Fabrizio, Enzo M.en
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