Tailoring super-hydrophobic properties of electrochemical biosensor for early cancer detection

Handle URI:
http://hdl.handle.net/10754/625234
Title:
Tailoring super-hydrophobic properties of electrochemical biosensor for early cancer detection
Authors:
Malara, Natalia; Gentile, Francesco; Ferrara, Lorenzo; Villani, Marco; Iannotta, Salvatore; Zappettini, Andrea; Di Fabrizio, Enzo M. ( 0000-0001-5886-4678 ) ; Trunzo, Valentina; Mollace, Vincenzo; Coppedé, Nicola
Abstract:
In this paper, we demonstrate an organic electrochemical transistor (OECT) based on the conductive polymer PEDOT:PSS for the analysis of the cell culture medium upon interaction with circulating cells isolated form peripheral blood sampling of health, sub-clinical and cancer patients. The device comprises arrays of super-hydrophobic micro-pillars in which a finite number of pillars incorporates nano-electrodes for site specific measurements of a solution. Due to its nano-scale architecture, the device realizes time and space resolved measurement of biological solution. Tumor metabolism could produce reactive species able to determine a different electronic behavior of correspondent microenviroment. On this basis, the device here presented the changes in the ESR signals was used to identify electronic changes occurring in the analysis of different type of microenvironment. Our results demonstrate that the device is able to register significative difference to differentiate healthy individuals form cancer patients, through an easy blood sampling. In conclusion, these preliminary data are suggestive of a novel test potentially useful to early identification of subjects at risk to development cancer disease.
KAUST Department:
Physical Sciences and Engineering (PSE) Division
Citation:
Malara N, Gentile F, Ferrara L, Villani M, Iannotta S, et al. (2016) Tailoring super-hydrophobic properties of electrochemical biosensor for early cancer detection. MRS Advances 1: 3545–3552. Available: http://dx.doi.org/10.1557/adv.2016.543.
Publisher:
Cambridge University Press (CUP)
Journal:
MRS Advances
Issue Date:
8-Aug-2016
DOI:
10.1557/adv.2016.543
Type:
Article
ISSN:
2059-8521
Sponsors:
This work has been partially funded from the Italian Minister of Health (Project n. GR-2010-2320665) and by the project Interregional Research Centre for Food Safety & health (IRC_FSH) (cod. PON a3-00359), granted to the Department of Health Science, University Magna Graecia. NC acknowledges Nicola Zambelli and Giacomo Benassi for technical support. NM acknowledges Prof. Bruno Silvestrini for scientific support. The authors would like to thank the patients and all health professionals involved at the University
Additional Links:
https://www.cambridge.org/core/journals/mrs-advances/article/tailoring-superhydrophobic-properties-of-electrochemical-biosensor-for-early-cancer-detection/E48FB47683DC576A9F444627ABB1C86A
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorMalara, Nataliaen
dc.contributor.authorGentile, Francescoen
dc.contributor.authorFerrara, Lorenzoen
dc.contributor.authorVillani, Marcoen
dc.contributor.authorIannotta, Salvatoreen
dc.contributor.authorZappettini, Andreaen
dc.contributor.authorDi Fabrizio, Enzo M.en
dc.contributor.authorTrunzo, Valentinaen
dc.contributor.authorMollace, Vincenzoen
dc.contributor.authorCoppedé, Nicolaen
dc.date.accessioned2017-07-19T10:45:05Z-
dc.date.available2017-07-19T10:45:05Z-
dc.date.issued2016-08-08en
dc.identifier.citationMalara N, Gentile F, Ferrara L, Villani M, Iannotta S, et al. (2016) Tailoring super-hydrophobic properties of electrochemical biosensor for early cancer detection. MRS Advances 1: 3545–3552. Available: http://dx.doi.org/10.1557/adv.2016.543.en
dc.identifier.issn2059-8521en
dc.identifier.doi10.1557/adv.2016.543en
dc.identifier.urihttp://hdl.handle.net/10754/625234-
dc.description.abstractIn this paper, we demonstrate an organic electrochemical transistor (OECT) based on the conductive polymer PEDOT:PSS for the analysis of the cell culture medium upon interaction with circulating cells isolated form peripheral blood sampling of health, sub-clinical and cancer patients. The device comprises arrays of super-hydrophobic micro-pillars in which a finite number of pillars incorporates nano-electrodes for site specific measurements of a solution. Due to its nano-scale architecture, the device realizes time and space resolved measurement of biological solution. Tumor metabolism could produce reactive species able to determine a different electronic behavior of correspondent microenviroment. On this basis, the device here presented the changes in the ESR signals was used to identify electronic changes occurring in the analysis of different type of microenvironment. Our results demonstrate that the device is able to register significative difference to differentiate healthy individuals form cancer patients, through an easy blood sampling. In conclusion, these preliminary data are suggestive of a novel test potentially useful to early identification of subjects at risk to development cancer disease.en
dc.description.sponsorshipThis work has been partially funded from the Italian Minister of Health (Project n. GR-2010-2320665) and by the project Interregional Research Centre for Food Safety & health (IRC_FSH) (cod. PON a3-00359), granted to the Department of Health Science, University Magna Graecia. NC acknowledges Nicola Zambelli and Giacomo Benassi for technical support. NM acknowledges Prof. Bruno Silvestrini for scientific support. The authors would like to thank the patients and all health professionals involved at the Universityen
dc.publisherCambridge University Press (CUP)en
dc.relation.urlhttps://www.cambridge.org/core/journals/mrs-advances/article/tailoring-superhydrophobic-properties-of-electrochemical-biosensor-for-early-cancer-detection/E48FB47683DC576A9F444627ABB1C86Aen
dc.rightsArchived with thanks to MRS Advancesen
dc.titleTailoring super-hydrophobic properties of electrochemical biosensor for early cancer detectionen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalMRS Advancesen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionDepartment of Experimental and Clinical Medicine, University of Magna Graecia, 88100 Catanzaro, Italyen
dc.contributor.institutionDepartment of Health Science, University of Magna Graecia, 88100 Catanzaro, Italyen
dc.contributor.institutionDepartment of Electrical Engineering and Information Technology, University Federico II, Naples, Italyen
dc.contributor.institutionIstituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italyen
dc.contributor.institutionIMEM-CNR Parco Area delle Scienze 37/A - 43124 Parma, Italyen
kaust.authorDi Fabrizio, Enzo M.en
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