Microfibrous silver-coated polymeric scaffolds with tunable mechanical properties

Handle URI:
http://hdl.handle.net/10754/625225
Title:
Microfibrous silver-coated polymeric scaffolds with tunable mechanical properties
Authors:
Kalakonda, Parvathalu.; Aldhahri, Musab A.; Abdel-wahab, Mohamed Shaaban; Tamayol, Ali; Moghaddam, K. Mollazadeh; Ben Rached, Fathia; Pain, Arnab ( 0000-0002-1755-2819 ) ; Khademhosseini, Ali ( 0000-0001-6322-8852 ) ; Memic, Adnan; Chaieb, Sahraoui ( 0000-0002-8053-3610 )
Abstract:
Electrospun scaffolds of poly(glycerol sebacate)/poly(ε-caprolactone) (PGS/PCL) have been used for engineered tissues due to their desirable thermal and mechanical properties as well as their tunable degradability. In this paper, we fabricated micro-fibrous scaffolds from a composite of PGS/PCL using a standard electrospinning method and coated them with silver (Ag). The low temperature coating method prevented substrate melting and the Ag coating decreases the pore size and increases the diameter of fibers which resulted in enhanced thermal and mechanical properties. We further compared the mechanical properties of the composite fibrous scaffolds with different thicknesses of Ag coated scaffolds. The composite fibrous scaffold with a 275 nm Ag coating showed higher tensile modulus (E) and ultimate tensile strength (UTS) without any post-processing treatment. Lastly, potential controlled release of the Ag coating from the composite fibrous scaffolds could present interesting biomedical applications.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Kalakonda P, Aldhahri MA, Abdel-wahab MS, Tamayol A, Moghaddam KM, et al. (2017) Microfibrous silver-coated polymeric scaffolds with tunable mechanical properties. RSC Adv 7: 34331–34338. Available: http://dx.doi.org/10.1039/c6ra25151j.
Publisher:
Royal Society of Chemistry (RSC)
Journal:
RSC Adv.
Issue Date:
7-Jul-2017
DOI:
10.1039/c6ra25151j
Type:
Article
ISSN:
2046-2069
Sponsors:
This project was funded by the National Plan for Science, Technology and Innovation (MAARIFAH) – King Abdulaziz City for Science and Technology – the Kingdom of Saudi Arabia – award number (12-MED3096-3). The authors thank the Science and Technology Unit, King Abdulaziz University. PK and SC thank KAUST for its support.
Additional Links:
http://pubs.rsc.org/en/Content/ArticleLanding/2017/RA/C6RA25151J#!divAbstract
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorKalakonda, Parvathalu.en
dc.contributor.authorAldhahri, Musab A.en
dc.contributor.authorAbdel-wahab, Mohamed Shaabanen
dc.contributor.authorTamayol, Alien
dc.contributor.authorMoghaddam, K. Mollazadehen
dc.contributor.authorBen Rached, Fathiaen
dc.contributor.authorPain, Arnaben
dc.contributor.authorKhademhosseini, Alien
dc.contributor.authorMemic, Adnanen
dc.contributor.authorChaieb, Sahraouien
dc.date.accessioned2017-07-19T10:45:02Z-
dc.date.available2017-07-19T10:45:02Z-
dc.date.issued2017-07-07en
dc.identifier.citationKalakonda P, Aldhahri MA, Abdel-wahab MS, Tamayol A, Moghaddam KM, et al. (2017) Microfibrous silver-coated polymeric scaffolds with tunable mechanical properties. RSC Adv 7: 34331–34338. Available: http://dx.doi.org/10.1039/c6ra25151j.en
dc.identifier.issn2046-2069en
dc.identifier.doi10.1039/c6ra25151jen
dc.identifier.urihttp://hdl.handle.net/10754/625225-
dc.description.abstractElectrospun scaffolds of poly(glycerol sebacate)/poly(ε-caprolactone) (PGS/PCL) have been used for engineered tissues due to their desirable thermal and mechanical properties as well as their tunable degradability. In this paper, we fabricated micro-fibrous scaffolds from a composite of PGS/PCL using a standard electrospinning method and coated them with silver (Ag). The low temperature coating method prevented substrate melting and the Ag coating decreases the pore size and increases the diameter of fibers which resulted in enhanced thermal and mechanical properties. We further compared the mechanical properties of the composite fibrous scaffolds with different thicknesses of Ag coated scaffolds. The composite fibrous scaffold with a 275 nm Ag coating showed higher tensile modulus (E) and ultimate tensile strength (UTS) without any post-processing treatment. Lastly, potential controlled release of the Ag coating from the composite fibrous scaffolds could present interesting biomedical applications.en
dc.description.sponsorshipThis project was funded by the National Plan for Science, Technology and Innovation (MAARIFAH) – King Abdulaziz City for Science and Technology – the Kingdom of Saudi Arabia – award number (12-MED3096-3). The authors thank the Science and Technology Unit, King Abdulaziz University. PK and SC thank KAUST for its support.en
dc.publisherRoyal Society of Chemistry (RSC)en
dc.relation.urlhttp://pubs.rsc.org/en/Content/ArticleLanding/2017/RA/C6RA25151J#!divAbstracten
dc.rightsThis Open Access Article is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported Licenceen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en
dc.titleMicrofibrous silver-coated polymeric scaffolds with tunable mechanical propertiesen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalRSC Adv.en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionCenter of Nanotechnology, King Abdulaziz University, Jeddah, Saudi Arabiaen
dc.contributor.institutionWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, USAen
dc.contributor.institutionHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, USAen
dc.contributor.institutionBiomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USAen
dc.contributor.institutionCollege of Animal Bioscience and Technology, Department of Bioindustrial Technologies, Konkuk University, Hwayang-dong, Kwangjin-gu, Seoul, Republic of Koreaen
dc.contributor.institutionDepartment of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabiaen
dc.contributor.institutionLawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 6R-2100, Berkeley, 94720 USAen
kaust.authorKalakonda, Parvathalu.en
kaust.authorBen Rached, Fathiaen
kaust.authorPain, Arnaben
kaust.authorChaieb, Sahraouien
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