Extracellular vesicles in gastrointestinal cancer in conjunction with microbiota: On the border of Kingdoms

Handle URI:
http://hdl.handle.net/10754/625163
Title:
Extracellular vesicles in gastrointestinal cancer in conjunction with microbiota: On the border of Kingdoms
Authors:
Barteneva, Natasha S.; Baiken, Yeldar; Fasler-Kan, Elizaveta; Alibek, Kenneth; Wang, Sheng; Maltsev, Natalia; Ponomarev, Eugeny D.; Sautbayeva, Zarina; Kauanova, Sholpan; Moore, Anna; Beglinger, Christoph; Vorobjev, Ivan A.
Abstract:
Extracellular vesicle (EV) production is a universal feature of metazoan cells as well as prokaryotes (bMVs - bacterial microvesicls). They are small vesicles with phospholipid membrane carrying proteins, DNA and different classes of RNAs and are heavily involved in intercellular communication acting as vectors of information to target cells. For the last decade, the interest in EV research has exponentially increased though thorough studies of their roles in various pathologies that was not previously possible due to technical limitations.This review focuses on research evaluating the role of EV production in gastrointestinal (GI) cancer development in conjunction with GI microbiota and inflammatory diseases. We also discuss recent studies on the promising role of EVs and their content as biomarkers for early diagnosis of GI cancers. The bMVs have also been implicated in the pathogenesis of GI chronic inflammatory diseases, however, possible role of bMVs in tumorigenesis remains underestimated. We propose that EVs from eukaryotic cells as well as from different microbial, fungi, parasitic species and edible plants in GI tract act as mediators of intracellular and inter-species communication, particularly facilitating tumour cell survival and multi-drug resistance. In conclusion, we suggest that matching sequences from EV proteomes (available from public databases) with known protein sequences of microbiome gut bacteria will be useful in identification of antigen mimicry between evolutionary conservative protein sequences. Using this approach we identified Bacteroides spp. pseudokinase with activation loop and homology to PDGFRα, providing a proof-of-concept strategy. We speculate that existence of microbial pseudokinase that ‘mimic” PDGFRα may be related to PDGFRα and Bacteroides spp. roles in colorectal carcinogenesis that require further investigation.
KAUST Department:
King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia
Citation:
Barteneva NS, Baiken Y, Fasler-Kan E, Alibek K, Wang S, et al. (2017) Extracellular vesicles in gastrointestinal cancer in conjunction with microbiota: On the border of Kingdoms. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. Available: http://dx.doi.org/10.1016/j.bbcan.2017.06.005.
Publisher:
Elsevier BV
Journal:
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Issue Date:
29-Jun-2017
DOI:
10.1016/j.bbcan.2017.06.005
Type:
Article
ISSN:
0304-419X
Sponsors:
Authors are grateful for grant support from Ministry of Science, Kazakhstan to I.A.V. and N.S.B, grant from Swiss IBD Cohort Study to E. F.-K., C.B. and N.S.B., Grant-in-Aid (University of Bern) to E.F.-K and Hong Kong RGC-ECS grant (ref. 24100314) to E.D.P. Space limitations prevented citation of all relevant literature. We also thank Aleksandra Gorelova (Harvard University) for help with editing of the manuscript.
Additional Links:
http://www.sciencedirect.com/science/article/pii/S0304419X17300975
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorBarteneva, Natasha S.en
dc.contributor.authorBaiken, Yeldaren
dc.contributor.authorFasler-Kan, Elizavetaen
dc.contributor.authorAlibek, Kennethen
dc.contributor.authorWang, Shengen
dc.contributor.authorMaltsev, Nataliaen
dc.contributor.authorPonomarev, Eugeny D.en
dc.contributor.authorSautbayeva, Zarinaen
dc.contributor.authorKauanova, Sholpanen
dc.contributor.authorMoore, Annaen
dc.contributor.authorBeglinger, Christophen
dc.contributor.authorVorobjev, Ivan A.en
dc.date.accessioned2017-07-06T09:43:05Z-
dc.date.available2017-07-06T09:43:05Z-
dc.date.issued2017-06-29en
dc.identifier.citationBarteneva NS, Baiken Y, Fasler-Kan E, Alibek K, Wang S, et al. (2017) Extracellular vesicles in gastrointestinal cancer in conjunction with microbiota: On the border of Kingdoms. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. Available: http://dx.doi.org/10.1016/j.bbcan.2017.06.005.en
dc.identifier.issn0304-419Xen
dc.identifier.doi10.1016/j.bbcan.2017.06.005en
dc.identifier.urihttp://hdl.handle.net/10754/625163-
dc.description.abstractExtracellular vesicle (EV) production is a universal feature of metazoan cells as well as prokaryotes (bMVs - bacterial microvesicls). They are small vesicles with phospholipid membrane carrying proteins, DNA and different classes of RNAs and are heavily involved in intercellular communication acting as vectors of information to target cells. For the last decade, the interest in EV research has exponentially increased though thorough studies of their roles in various pathologies that was not previously possible due to technical limitations.This review focuses on research evaluating the role of EV production in gastrointestinal (GI) cancer development in conjunction with GI microbiota and inflammatory diseases. We also discuss recent studies on the promising role of EVs and their content as biomarkers for early diagnosis of GI cancers. The bMVs have also been implicated in the pathogenesis of GI chronic inflammatory diseases, however, possible role of bMVs in tumorigenesis remains underestimated. We propose that EVs from eukaryotic cells as well as from different microbial, fungi, parasitic species and edible plants in GI tract act as mediators of intracellular and inter-species communication, particularly facilitating tumour cell survival and multi-drug resistance. In conclusion, we suggest that matching sequences from EV proteomes (available from public databases) with known protein sequences of microbiome gut bacteria will be useful in identification of antigen mimicry between evolutionary conservative protein sequences. Using this approach we identified Bacteroides spp. pseudokinase with activation loop and homology to PDGFRα, providing a proof-of-concept strategy. We speculate that existence of microbial pseudokinase that ‘mimic” PDGFRα may be related to PDGFRα and Bacteroides spp. roles in colorectal carcinogenesis that require further investigation.en
dc.description.sponsorshipAuthors are grateful for grant support from Ministry of Science, Kazakhstan to I.A.V. and N.S.B, grant from Swiss IBD Cohort Study to E. F.-K., C.B. and N.S.B., Grant-in-Aid (University of Bern) to E.F.-K and Hong Kong RGC-ECS grant (ref. 24100314) to E.D.P. Space limitations prevented citation of all relevant literature. We also thank Aleksandra Gorelova (Harvard University) for help with editing of the manuscript.en
dc.publisherElsevier BVen
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0304419X17300975en
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, [, , (2017-06-29)] DOI: 10.1016/j.bbcan.2017.06.005 . © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectextracellular vesiclesen
dc.subjectexosomesen
dc.subjectinter-species communicationen
dc.subjectgastrointestinal canceren
dc.subjectBacteroides fragilisen
dc.subjectpseudokinaseen
dc.titleExtracellular vesicles in gastrointestinal cancer in conjunction with microbiota: On the border of Kingdomsen
dc.typeArticleen
dc.contributor.departmentKing Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabiaen
dc.identifier.journalBiochimica et Biophysica Acta (BBA) - Reviews on Canceren
dc.eprint.versionPost-printen
dc.contributor.institutionDepartment of Pediatrics, Harvard Medical School and Boston Children Hospital, Boston, USAen
dc.contributor.institutionSchool of Science and Technology, Nazarbayev University, Astana, Kazakhstanen
dc.contributor.institutionDepartment of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerlanden
dc.contributor.institutionDepartment of Pediatric Surgery, Children’s Hospital, Inselspital and Department of Clinical Research, University of Bern, Bern, Switzerlanden
dc.contributor.institutionLocus Solutions Inc., OH, 44139 USAen
dc.contributor.institutionDepartment of Human Genetics and USA Computation Institute, University of Chicago, Chicago, USAen
dc.contributor.institutionSchool of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kongen
dc.contributor.institutionMolecular Imaging Laboratory, Massachusetts, General Hospital and Harvard Medical School, Boston, USAen
dc.contributor.institutionDepartment of Biomedicine, University of Basel and Division of Gastroenterology, University Hospital Basel, Basel, Switzerlanden
kaust.authorWang, Shengen
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