The Arabidopsis SWI/SNF protein BAF60 mediates seedling growth control by modulating DNA accessibility

Handle URI:
http://hdl.handle.net/10754/625066
Title:
The Arabidopsis SWI/SNF protein BAF60 mediates seedling growth control by modulating DNA accessibility
Authors:
Jégu, Teddy; Veluchamy, Alaguraj; Ramirez-Prado, Juan S.; Rizzi-Paillet, Charley; Perez, Magalie; Lhomme, Anaïs; Latrasse, David; Coleno, Emeline; Vicaire, Serge; Legras, Stéphanie; Jost, Bernard; Rougée, Martin; Barneche, Fredy; Bergounioux, Catherine; Crespi, Martin; Mahfouz, Magdy M. ( 0000-0002-0616-6365 ) ; Hirt, Heribert ( 0000-0003-3119-9633 ) ; Raynaud, Cécile; Benhamed, Moussa ( 0000-0002-4181-1702 )
Abstract:
Plant adaptive responses to changing environments involve complex molecular interplays between intrinsic and external signals. Whilst much is known on the signaling components mediating diurnal, light, and temperature controls on plant development, their influence on chromatin-based transcriptional controls remains poorly explored.In this study we show that a SWI/SNF chromatin remodeler subunit, BAF60, represses seedling growth by modulating DNA accessibility of hypocotyl cell size regulatory genes. BAF60 binds nucleosome-free regions of multiple G box-containing genes, opposing in cis the promoting effect of the photomorphogenic and thermomorphogenic regulator Phytochrome Interacting Factor 4 (PIF4) on hypocotyl elongation. Furthermore, BAF60 expression level is regulated in response to light and daily rhythms.These results unveil a short path between a chromatin remodeler and a signaling component to fine-tune plant morphogenesis in response to environmental conditions.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Jégu T, Veluchamy A, Ramirez-Prado JS, Rizzi-Paillet C, Perez M, et al. (2017) The Arabidopsis SWI/SNF protein BAF60 mediates seedling growth control by modulating DNA accessibility. Genome Biology 18. Available: http://dx.doi.org/10.1186/s13059-017-1246-7.
Publisher:
Springer Nature
Journal:
Genome Biology
Issue Date:
15-Jun-2017
DOI:
10.1186/s13059-017-1246-7
Type:
Article
ISSN:
1474-760X
Sponsors:
This work was funded by King Abdullah University of Science and Technology (KAUST) and Université Paris Sud. The IPS2 benefits from the support of the LabExSaclay Plant Sciences-SPS (ANR-10-LABX-0040-SPS).
Additional Links:
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1246-7
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorJégu, Teddyen
dc.contributor.authorVeluchamy, Alagurajen
dc.contributor.authorRamirez-Prado, Juan S.en
dc.contributor.authorRizzi-Paillet, Charleyen
dc.contributor.authorPerez, Magalieen
dc.contributor.authorLhomme, Anaïsen
dc.contributor.authorLatrasse, Daviden
dc.contributor.authorColeno, Emelineen
dc.contributor.authorVicaire, Sergeen
dc.contributor.authorLegras, Stéphanieen
dc.contributor.authorJost, Bernarden
dc.contributor.authorRougée, Martinen
dc.contributor.authorBarneche, Fredyen
dc.contributor.authorBergounioux, Catherineen
dc.contributor.authorCrespi, Martinen
dc.contributor.authorMahfouz, Magdy M.en
dc.contributor.authorHirt, Heriberten
dc.contributor.authorRaynaud, Cécileen
dc.contributor.authorBenhamed, Moussaen
dc.date.accessioned2017-06-19T09:21:46Z-
dc.date.available2017-06-19T09:21:46Z-
dc.date.issued2017-06-15en
dc.identifier.citationJégu T, Veluchamy A, Ramirez-Prado JS, Rizzi-Paillet C, Perez M, et al. (2017) The Arabidopsis SWI/SNF protein BAF60 mediates seedling growth control by modulating DNA accessibility. Genome Biology 18. Available: http://dx.doi.org/10.1186/s13059-017-1246-7.en
dc.identifier.issn1474-760Xen
dc.identifier.doi10.1186/s13059-017-1246-7en
dc.identifier.urihttp://hdl.handle.net/10754/625066-
dc.description.abstractPlant adaptive responses to changing environments involve complex molecular interplays between intrinsic and external signals. Whilst much is known on the signaling components mediating diurnal, light, and temperature controls on plant development, their influence on chromatin-based transcriptional controls remains poorly explored.In this study we show that a SWI/SNF chromatin remodeler subunit, BAF60, represses seedling growth by modulating DNA accessibility of hypocotyl cell size regulatory genes. BAF60 binds nucleosome-free regions of multiple G box-containing genes, opposing in cis the promoting effect of the photomorphogenic and thermomorphogenic regulator Phytochrome Interacting Factor 4 (PIF4) on hypocotyl elongation. Furthermore, BAF60 expression level is regulated in response to light and daily rhythms.These results unveil a short path between a chromatin remodeler and a signaling component to fine-tune plant morphogenesis in response to environmental conditions.en
dc.description.sponsorshipThis work was funded by King Abdullah University of Science and Technology (KAUST) and Université Paris Sud. The IPS2 benefits from the support of the LabExSaclay Plant Sciences-SPS (ANR-10-LABX-0040-SPS).en
dc.publisherSpringer Natureen
dc.relation.urlhttps://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1246-7en
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectMorphogenesisen
dc.subjectG-boxen
dc.subjectchromatinen
dc.subjectPhytochrome Interacting Factoren
dc.subjectSwi/snfen
dc.subjectPif4en
dc.subjectDna Accessibilityen
dc.titleThe Arabidopsis SWI/SNF protein BAF60 mediates seedling growth control by modulating DNA accessibilityen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalGenome Biologyen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionInstitut of Plant Sciences Paris-Saclay (IPS2), UMR 9213/UMR1403, CNRS, INRA, Université Paris-Sud, Université d'Evry, Université Paris-Diderot, Sorbonne Paris-Cité, Bâtiment 630, 91405, Orsay, France.en
dc.contributor.institutionHoward Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.en
dc.contributor.institutionDepartment of Genetics, Harvard Medical School, Boston, MA, 02114, USA.en
dc.contributor.institutionPlateforme Biopuces et séquençage, IGBMC, 1 rue Laurent Fries Parc d'Innovation, 67400, Illkirch, France.en
dc.contributor.institutionEcole Normale Supérieure, PSL Research University, Institut de Biologie de l'Ecole Normale Supérieure (IBENS), CNRS UMR 8197, INSERM U1024, 46 rue d'Ulm, F-75005, Paris, France.en
kaust.authorVeluchamy, Alagurajen
kaust.authorRamirez-Prado, Juan S.en
kaust.authorMahfouz, Magdy M.en
kaust.authorHirt, Heriberten
kaust.authorBenhamed, Moussaen
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