A Microfluidic Ion Pump for In Vivo Drug Delivery

Handle URI:
http://hdl.handle.net/10754/623783
Title:
A Microfluidic Ion Pump for In Vivo Drug Delivery
Authors:
Uguz, Ilke; Proctor, Christopher M.; Curto, Vincenzo F.; Pappa, Anna-Maria; Donahue, Mary J.; Ferro, Magali; Owens, Róisín M.; Khodagholy, Dion; Inal, Sahika ( 0000-0002-1166-1512 ) ; Malliaras, George G. ( 0000-0002-4582-8501 )
Abstract:
Implantable devices offer an alternative to systemic delivery of drugs for the treatment of neurological disorders. A microfluidic ion pump (µFIP), capable of delivering a drug without the solvent through electrophoresis, is developed. The device is characterized in vitro by delivering γ-amino butyric acid to a target solution, and demonstrates low-voltage operation, high drug-delivery capacity, and high ON/OFF ratio. It is also demonstrated that the device is suitable for cortical delivery in vivo by manipulating the local ion concentration in an animal model and altering neural behavior. These results show that µFIPs represent a significant step forward toward the development of implantable drug-delivery systems.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Uguz I, Proctor CM, Curto VF, Pappa A-M, Donahue MJ, et al. (2017) A Microfluidic Ion Pump for In Vivo Drug Delivery. Advanced Materials: 1701217. Available: http://dx.doi.org/10.1002/adma.201701217.
Publisher:
Wiley-Blackwell
Journal:
Advanced Materials
Issue Date:
15-May-2017
DOI:
10.1002/adma.201701217
Type:
Article
ISSN:
0935-9648
Sponsors:
I.U. and C.M.P. contributed equally to this work. Financial support from the Région PACA, the Whitaker Foundation, and the Fondation pour la Recherche Médicale (FRM DBS20131128446) is acknowledged. I.U. thanks Microvitae for supporting the bourse Région.
Additional Links:
http://onlinelibrary.wiley.com/doi/10.1002/adma.201701217/full
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorUguz, Ilkeen
dc.contributor.authorProctor, Christopher M.en
dc.contributor.authorCurto, Vincenzo F.en
dc.contributor.authorPappa, Anna-Mariaen
dc.contributor.authorDonahue, Mary J.en
dc.contributor.authorFerro, Magalien
dc.contributor.authorOwens, Róisín M.en
dc.contributor.authorKhodagholy, Dionen
dc.contributor.authorInal, Sahikaen
dc.contributor.authorMalliaras, George G.en
dc.date.accessioned2017-05-31T11:23:05Z-
dc.date.available2017-05-31T11:23:05Z-
dc.date.issued2017-05-15en
dc.identifier.citationUguz I, Proctor CM, Curto VF, Pappa A-M, Donahue MJ, et al. (2017) A Microfluidic Ion Pump for In Vivo Drug Delivery. Advanced Materials: 1701217. Available: http://dx.doi.org/10.1002/adma.201701217.en
dc.identifier.issn0935-9648en
dc.identifier.doi10.1002/adma.201701217en
dc.identifier.urihttp://hdl.handle.net/10754/623783-
dc.description.abstractImplantable devices offer an alternative to systemic delivery of drugs for the treatment of neurological disorders. A microfluidic ion pump (µFIP), capable of delivering a drug without the solvent through electrophoresis, is developed. The device is characterized in vitro by delivering γ-amino butyric acid to a target solution, and demonstrates low-voltage operation, high drug-delivery capacity, and high ON/OFF ratio. It is also demonstrated that the device is suitable for cortical delivery in vivo by manipulating the local ion concentration in an animal model and altering neural behavior. These results show that µFIPs represent a significant step forward toward the development of implantable drug-delivery systems.en
dc.description.sponsorshipI.U. and C.M.P. contributed equally to this work. Financial support from the Région PACA, the Whitaker Foundation, and the Fondation pour la Recherche Médicale (FRM DBS20131128446) is acknowledged. I.U. thanks Microvitae for supporting the bourse Région.en
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/adma.201701217/fullen
dc.subjectPedot:pssen
dc.subjectOrganic Bioelectronicsen
dc.subjectOrganic Electronic Ion Pumpsen
dc.titleA Microfluidic Ion Pump for In Vivo Drug Deliveryen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalAdvanced Materialsen
dc.contributor.institutionDepartment of Bioelectronics; Ecole Nationale Supérieure des Mines; CMP-EMSE, MOC 13541 Gardanne Franceen
dc.contributor.institutionDepartment of Electrical Engineering; Columbia University; NY 10027 USAen
kaust.authorInal, Sahikaen
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