Thielavins W–Z7, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004

Handle URI:
http://hdl.handle.net/10754/623417
Title:
Thielavins W–Z7, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004
Authors:
Han, Zhuang; Li, Yong-Xin; Liu, Ling-Li; Lu, Liang; Guo, Xianrong; Zhang, Xixiang ( 0000-0002-3478-6414 ) ; Zhang, Xiao-Yong; Qi, Shu-Hua; Xu, Ying; Qian, Pei-Yuan
Abstract:
Eleven new depsides-thielavins W-Z (1-4) and thielavins Z₁-Z₇ (5-11)-and also four known thielavins-A, H, J, and K (12-15)-were isolated from the ethyl acetate extract of a marine-derived fungal strain Thielavia sp UST030930-004. All of these compounds were evaluated for antifouling activity against cyprids of the barnacle Balanus (=Amphibalanus) amphitrite. The results showed that compounds 1-3 and 6-13 were active, with EC50 values ranging from 2.95 ± 0.59 to 69.19 ± 9.51 μM, respectively. The inhibitive effect of compounds 1-3 and 7 was reversible. This is the first description of the antifouling activity of thielavins against barnacle cyprids.
KAUST Department:
Imaging & Characterization Core lab, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia. xianrong.guo@kaust.edu.sa.; Physical Sciences and Engineering (PSE) Division
Citation:
Han Z, Li Y-X, Liu L-L, Lu L, Guo X-R, et al. (2017) Thielavins W–Z7, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004. Marine Drugs 15: 128. Available: http://dx.doi.org/10.3390/md15050128.
Publisher:
MDPI AG
Journal:
Marine Drugs
Issue Date:
2-May-2017
DOI:
10.3390/md15050128
Type:
Article
ISSN:
1660-3397
Sponsors:
We are grateful for the financial support from the China Ocean Mineral Resources Research and Development Association (DY135), Youth Innovation Promotion Association CAS (QC2015388), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB06010204), Hainan Special Project for Ocean Exploration (XH201410), the Natural Science Foundation of Hainan Province (414186), and Institute of Deep-Sea Science and Engineering (SIDSSE-QN-201303).
Additional Links:
http://www.mdpi.com/1660-3397/15/5/128
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorHan, Zhuangen
dc.contributor.authorLi, Yong-Xinen
dc.contributor.authorLiu, Ling-Lien
dc.contributor.authorLu, Liangen
dc.contributor.authorGuo, Xianrongen
dc.contributor.authorZhang, Xixiangen
dc.contributor.authorZhang, Xiao-Yongen
dc.contributor.authorQi, Shu-Huaen
dc.contributor.authorXu, Yingen
dc.contributor.authorQian, Pei-Yuanen
dc.date.accessioned2017-05-09T08:34:34Z-
dc.date.available2017-05-09T08:34:34Z-
dc.date.issued2017-05-02en
dc.identifier.citationHan Z, Li Y-X, Liu L-L, Lu L, Guo X-R, et al. (2017) Thielavins W–Z7, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004. Marine Drugs 15: 128. Available: http://dx.doi.org/10.3390/md15050128.en
dc.identifier.issn1660-3397en
dc.identifier.doi10.3390/md15050128en
dc.identifier.urihttp://hdl.handle.net/10754/623417-
dc.description.abstractEleven new depsides-thielavins W-Z (1-4) and thielavins Z₁-Z₇ (5-11)-and also four known thielavins-A, H, J, and K (12-15)-were isolated from the ethyl acetate extract of a marine-derived fungal strain Thielavia sp UST030930-004. All of these compounds were evaluated for antifouling activity against cyprids of the barnacle Balanus (=Amphibalanus) amphitrite. The results showed that compounds 1-3 and 6-13 were active, with EC50 values ranging from 2.95 ± 0.59 to 69.19 ± 9.51 μM, respectively. The inhibitive effect of compounds 1-3 and 7 was reversible. This is the first description of the antifouling activity of thielavins against barnacle cyprids.en
dc.description.sponsorshipWe are grateful for the financial support from the China Ocean Mineral Resources Research and Development Association (DY135), Youth Innovation Promotion Association CAS (QC2015388), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB06010204), Hainan Special Project for Ocean Exploration (XH201410), the Natural Science Foundation of Hainan Province (414186), and Institute of Deep-Sea Science and Engineering (SIDSSE-QN-201303).en
dc.publisherMDPI AGen
dc.relation.urlhttp://www.mdpi.com/1660-3397/15/5/128en
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectantifoulingen
dc.subjectMarine-derived Fungusen
dc.subjectThielavinsen
dc.subjectBalanus (=Amphibalanus) Amphitriteen
dc.subjectThielavia Sp.en
dc.titleThielavins W–Z7, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004en
dc.typeArticleen
dc.contributor.departmentImaging & Characterization Core lab, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia. xianrong.guo@kaust.edu.sa.en
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalMarine Drugsen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionDivision of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China. zhuanghan@idsse.ac.cn.en
dc.contributor.institutionDivision of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China. liyongxin@connect.ust.hk.en
dc.contributor.institutionDivision of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China. leonie@nwsuaf.edu.cn.en
dc.contributor.institutionDivision of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China. luliangust@163.com.en
dc.contributor.institutionKey Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China. zhangxiaoyong@scsio.ac.cn.en
dc.contributor.institutionKey Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China. shuhuaqi@scsio.ac.cn.en
dc.contributor.institutionCollege of Life Science, Shenzhen University, 3688 Nanhai Ave, Shenzhen 518060, China. boxuying@szu.edu.cn.en
dc.contributor.institutionDivision of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China. boxuying@szu.edu.cn.en
kaust.authorGuo, Xianrongen
kaust.authorZhang, Xixiangen
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