Multiple Scattering Model for Optical Coherence Tomography with Rytov Approximation

Handle URI:
http://hdl.handle.net/10754/623270
Title:
Multiple Scattering Model for Optical Coherence Tomography with Rytov Approximation
Authors:
Li, Muxingzi ( 0000-0003-2126-8578 )
Abstract:
Optical Coherence Tomography (OCT) is a coherence-gated, micrometer-resolution imaging technique that focuses a broadband near-infrared laser beam to penetrate into optical scattering media, e.g. biological tissues. The OCT resolution is split into two parts, with the axial resolution defined by half the coherence length, and the depth-dependent lateral resolution determined by the beam geometry, which is well described by a Gaussian beam model. The depth dependence of lateral resolution directly results in the defocusing effect outside the confocal region and restricts current OCT probes to small numerical aperture (NA) at the expense of lateral resolution near the focus. Another limitation on OCT development is the presence of a mixture of speckles due to multiple scatterers within the coherence length, and other random noise. Motivated by the above two challenges, a multiple scattering model based on Rytov approximation and Gaussian beam optics is proposed for the OCT setup. Some previous papers have adopted the first Born approximation with the assumption of small perturbation of the incident field in inhomogeneous media. The Rytov method of the same order with smooth phase perturbation assumption benefits from a wider spatial range of validity. A deconvolution method for solving the inverse problem associated with the first Rytov approximation is developed, significantly reducing the defocusing effect through depth and therefore extending the feasible range of NA.
Advisors:
Heidrich, Wolfgang ( 0000-0002-4227-8508 )
Committee Member:
Sundaramoorthi, Ganesh ( 0000-0003-3471-6384 ) ; Leiknes, TorOve ( 0000-0003-4046-5622 )
KAUST Department:
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Program:
Applied Mathematics and Computational Science
Issue Date:
24-Apr-2017
Type:
Thesis
Appears in Collections:
Theses

Full metadata record

DC FieldValue Language
dc.contributor.advisorHeidrich, Wolfgangen
dc.contributor.authorLi, Muxingzien
dc.date.accessioned2017-04-24T08:17:28Z-
dc.date.available2017-04-24T08:17:28Z-
dc.date.issued2017-04-24-
dc.identifier.urihttp://hdl.handle.net/10754/623270-
dc.description.abstractOptical Coherence Tomography (OCT) is a coherence-gated, micrometer-resolution imaging technique that focuses a broadband near-infrared laser beam to penetrate into optical scattering media, e.g. biological tissues. The OCT resolution is split into two parts, with the axial resolution defined by half the coherence length, and the depth-dependent lateral resolution determined by the beam geometry, which is well described by a Gaussian beam model. The depth dependence of lateral resolution directly results in the defocusing effect outside the confocal region and restricts current OCT probes to small numerical aperture (NA) at the expense of lateral resolution near the focus. Another limitation on OCT development is the presence of a mixture of speckles due to multiple scatterers within the coherence length, and other random noise. Motivated by the above two challenges, a multiple scattering model based on Rytov approximation and Gaussian beam optics is proposed for the OCT setup. Some previous papers have adopted the first Born approximation with the assumption of small perturbation of the incident field in inhomogeneous media. The Rytov method of the same order with smooth phase perturbation assumption benefits from a wider spatial range of validity. A deconvolution method for solving the inverse problem associated with the first Rytov approximation is developed, significantly reducing the defocusing effect through depth and therefore extending the feasible range of NA.en
dc.language.isoenen
dc.subjectOptical coherence tomographyen
dc.subjectscatteringen
dc.subjectDenoisingen
dc.subjectinverse scattering problemen
dc.subjectrytov approximationen
dc.titleMultiple Scattering Model for Optical Coherence Tomography with Rytov Approximationen
dc.typeThesisen
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
thesis.degree.grantorKing Abdullah University of Science and Technologyen_GB
dc.contributor.committeememberSundaramoorthi, Ganeshen
dc.contributor.committeememberLeiknes, TorOveen
thesis.degree.disciplineApplied Mathematics and Computational Scienceen
thesis.degree.nameMaster of Scienceen
dc.person.id143269en
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